Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Lv, Y.; Pan, Q.; Bligh, S.W.A.; Li, H.; Wu, H; Sang, Qingqing; Zhu, Li-Min (2017)
Publisher: Elsevier
Languages: English
Types: Article
Subjects: UOWSAT
In this work, a smart drug delivery system of core–sheath nanofiber is reported. The core-sheath nanofibers were prepared with thermoresponsive poly-(N-isopropylacrylamide) (PNIPAAm) (as core) and hydrophobic ethylcellulose (EC) (as sheath) by coaxial electrospinning. Analogous medicated fibers were prepared by loading with a model drug ketoprofen (KET). The fibers were cylindrical without phase separation and have visible core-sheath structure as shown by scanning and transmission electron microscopy. X-ray diffraction patterns demonstrated the drug with the amorphous physical form was present in the fiber matrix. Fourier transform infrared spectroscopy analysis was conducted, finding that there were significant intermolecular interactions between KET and the polymers. Water contact angle measurements proved that the core-sheath fibers from hydrophobic transformed into hydrophobic when the temperature reached the lower critical solution temperature. In vitro drug-release study of nanofibers with KET displayed that the coaxial nanofibers were able to synergistically combine the characteristics of the two polymers producing a temperature-sensitive drug delivery system with sustained release properties. In addition, they were established to be non-toxic and suitable for cell growth. These findings show that the core–sheath nanofiber is a potential candidate for controlling drug delivery system.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • [1] Yang T, Yao Y, Lin Y, et al. Electrospinning of polyacrylonitrile fibers from ionic liquid solution. Appl Phys A, 2010, 98(3):517-523.
    • [2] Jin W J, Jeon H J, Kim J H, et al. A study on the preparation of poly(vinyl alcohol) nanofibers containing silver nanoparticles. Synth Met, 2007, 157(10-12):454-459.
    • [3] Min B M, Lee G, Kim S H, et al. Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro. Biomaterials, 2004, 25(7-8):1289-1297.
    • [4] Li X, Qian Q, Zheng W, et al. Preparation and Characteristics of LaOCl Nanotubes by Coaxial Electrospinning. Mater Lett, 2012, 80(8):43-45.
    • [5] Wang B, Zhang P P, Williams G R, et al. A simple route to form magnetic chitosan nanoparticles from coaxial-electrospun composite nanofibers. J Mater Sci, 2013, 48(11):3991-3998.
    • [6] Zander N E. Hierarchically Structured Electrospun Fibers. Polymers, 2013, 5(1):19-44.
    • [7] Fu Y, Guan J, Guo S, et al. Human urine-derived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis. J Transl Med, 2013, 12(1):1-14.
    • [8] Christina K, Alessandra A, Alessandra A, et al. Fabrication, functionalization, and application of electrospun biopolymer nanofibers. Crit Rev Food Sci Nutr, 2008, 48(8):775-797.
    • [9] Hedges A R. The Application of Soft-Calender. Chem Rev, 1998, 98(98):2035-2044.
    • [10] Qiu S, Liu L, Wang B, et al. Facile Synthesis of Carbazole-Containing Semiladder Polyphenylenes for Pure-Blue Electroluminescence. Macromolecules, 2005, 38(16):6782-6788.
    • [11] Ying L, Kang E T, Neoh K G, et al. Drug permeation through temperature-sensitive membranes prepared from poly(vinylidene fluoride) with grafted poly( N -isopropylacrylamide) chains. J Membr Sci, 2004, 243(s 1-2):253-262.
    • [12] Ying L, Wang P, And E T K, et al. Synthesis and Characterization of Poly(acrylic acid)-graft-poly(vinylidene fluoride) Copolymers and pH-Sensitive Membranes. Macromolecules, 2001, 35(3):673-679.
    • [13] Maxim Orlov , Ihor Tokarev , Andreas Scholl, et al. pH-Responsive Thin Film Membranes from Poly(2-vinylpyridine):  Water Vapor-Induced Formation of a Microporous Structure. Macromolecules, 2007, 40(40):2086-2091.
    • [14] Fu-Jian X, En-Tang K, Koon-Gee N. pH- and temperature-responsive hydrogels from crosslinked triblock copolymers prepared via consecutive atom transfer radical polymerizations. Biomaterials, 2006, 27(14):2787-2797.
    • [15] Xian-Zheng Z, Patti J L, Chih-Chang C. Fabrication and characterization of a smart drug delivery system: microsphere in hydrogel. Biomaterials, 2005, 26(16):3299-3309.
    • [16] Huber D L, Manginell R P, Samara M A, et al. Programmed adsorption and release of proteins in a microfluidic device. Sci, 2003, 301(5631):352-354.
  • No related research data.
  • Discovered through pilot similarity algorithms. Send us your feedback.

Share - Bookmark

Cite this article