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Boateng, Joshua; Catanzano, Ovidio; Docking, Rachael; Schofield, Pat
Languages: English
Types: Unknown

Classified by OpenAIRE into

mesheuropmc: integumentary system
Background: \ud Pain is a ubiquitous problem in patients with chronic leg wounds. Recent studies have reported that 17 - 65% of patients experience severe or continuous pain that, associated with other characteristics of chronic ulcers such as odour, have debilitating effects on the patients including both their mental and psychological wellbeing. The aim of this work is to develop advanced wound dressings for local delivery of an analgesic drug that can help to manage pain associated with chronic leg ulcers in older adults. The addition of hyaluronic acid (HA) in the composition added beneficial and well recognized HA properties in the wound healing process.\ud \ud Methods: \ud Advanced dressings loaded with an analgesic drug (lidocaine) were formulated as lyophilised xerogels (wafers) by freeze-drying. Different HA ratios by weight were used to improve the wafer characteristics. The dressings were tested for functional characteristics including mechanical strength, porous microstructure, stability, polymorphic/amorphous transitions, hydration, swelling and in vitro mucoadhesion. An HPLC method was developed to assess lidocaine release from wafers.\ud \ud Results: \ud On the basis of feasibility study of the use of analgesic dressings in older adults with leg ulcers, an advanced dressing loaded with lidocaine was formulated. Wafers, due to their porous nature, have proved to be suitable for medium to high exuding wounds (common in leg ulcers), whilst still maintaining their physical integrity. Both blank and drug-loaded wafers were soft, flexible, elegant in appearance and non-brittle in nature. The addition of HA had an influence on wafer structure changing their properties, but mechanical characterisation demonstrated that the wafers were strong enough to withstand normal stresses but also flexible to prevent damage to newly formed skin tissue. The lidocaine release from the optimised dressing showed continuous release for over 12 h.\ud \ud Conclusions: \ud Wafer seems to be a very promising system for delivery of analgesic drug to the wound. Further studies are in progress to evaluate in vitro activity of the dressings and role of HA in the wound healing process.
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