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McGuinness, D. (2013)
Publisher: SciDoc Publishers
Languages: English
Types: Article
Subjects: Fractal Entropy, cellular dynamics, Cancer
The concept of a unified theory for cancer is not novel, in fact it was first proposed by Spandidos in 1986[1] where it was postulated that cancer development was an orchestrated series of genetic and epigenetic events which were significantly related to both genetic and environmental factors. In a recent review by Garland[2] another unified theory has emerged and a new model of cancer development has been proposed. In this case, it has been defined as retuning the energy required by a cell to maintain homeostasis, to a state of maximum energy entropy (dissipation) arising from increased cellular dynamics. Garland has postulated that this process can be driven by specific mutations, or other molecular changes, that will re-direct energy flow within a cell to one favouring neoplastic transformation.
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    • Spandidos D.A (1986) A unified theory for the development of cancer. Biosci Rep. 6(8):691-708.
    • Garland J (2013) Energy management - a critical role in cancer induction? Crit Rev Oncol Hematol. doi: 10.1016/j.critrevonc.2013.04.001.
    • [Epub ahead of print] Shiels P.G and Davies R.W (2004) Ageing and death in neurones.
    • In: Davies R.W. and Morris B.J. (eds.) Molecular Biology of the Neuron. Series: Molecular and cellular neurobiology series. Oxford University Press, Oxford, UK, pp. 435-464. ISBN 9780198509981 Warburg O (1956) On the origin of cancer cells. Science 123 (3191): 309-314.
    • Sebasti├ín C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsy (2012) The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
    • Cell. 151(6):1185-1199. doi: 10.1016/j.cell.2012.10.047.
    • Wang X, Peralta S, Moraes C.T (2013) Mitochondrial alterations during carcinogenesis: a review of metabolic transformation and targets for anticancer treatments. Adv Cancer Res. 119: 127-160. doi: 10.1016/B978-0-12-407190-2.00004-6. [Epub ahead of print]
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