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Buffet-Bataillon, Sylvie; Tattevin, Pierre; Maillard, Jean-Yves; Bonnaure-Mallet, Martine; Jolivet-Gougeon, Anne (2016)
Publisher: Future Medicine
Languages: English
Types: Article
Subjects: RM
Biocides, primarily those containing quaternary ammonium compounds (QAC), are heavily used in hospital environments and various industries (e.g., food, water, cosmetic). To date, little attention has been paid to potential implications of QAC use in the emergence of antibiotic resistance, especially fluoroquinolone-resistant bacteria in patients and in the environment. QAC-induced overexpression of efflux pumps can lead to: cross resistance with fluoroquinolones mediated by multidrug efflux pumps; stress response facilitating mutation in the Quinolone Resistance Determining Region; and biofilm formation increasing the risk of transfer of mobile genetic elements carrying fluoroquinolone or QAC resistance determinants. By following the European Biocidal Product Regulation, manufacturers of QAC are required to ensure that their QAC-based biocidal products are safe and will not contribute to emerging bacterial resistance.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

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    •  These data described the methodologies for measuring efflux pump inhibition, could allow the design, and subsequent experimental verification of potential efflux pump inhibitors (EPIs). They explored new compounds that could reverse drug resistance in Gram-negative pathogens. Wassenaar TM, Ussery D, Nielsen LN, Ingmer H. Review and phylogenetic analysis of qac genes that reduce susceptibility to quaternary ammonium compounds in Staphylococcus species. Eur. J. Microbiol. Immunol. (Bp), 5(1), 44-61 (2015).
    •  The aim of this study was to list the qac genes in staphylococci, belonging to Major Facilitator Superfamily (MFS) and Small Multidrug Resistance (SMR) families. Despite their resemblance in substrate specificity, the Qac proteins have little in common, and a number of phylogenetic trees of SMR Qac proteins are presented. Buffet-Bataillon S, Le Jeune A, Le Gall-David S, Bonnaure-Mallet M, JolivetGougeon A. Molecular mechanisms of higher MICs of antibiotics and quaternary ammonium compounds for Escherichia coli isolated from bacteraemia. J. Antimicrob. Chemother., 67(12), 2837-2842 (2012).
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