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Weir, RE; Black, GF; Dockrell, HM; Floyd, S; Fine, PE; Chaguluka, SD; Stenson, S; King, E; Nazareth, B; Warndorff, DK; Ngwira, B; Crampin, AC; Mwaungulu, L; Sichali, L; Jarman, E; Donovan, L; Blackwell, JM (2004)
Publisher: American Society for Microbiology
Languages: English
Types: Article
Subjects: Host Response and Inflammation

Classified by OpenAIRE into

mesheuropmc: parasitic diseases
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial purified protein derivatives (PPDs). The rank order in stimulatory potency for different PPDs was the same for all three cytokines. Before vaccination Malawians made higher pro- and anti-inflammatory responses than did United Kingdom subjects. Fewer than 5% of United Kingdom subjects made IL-10 in response to any PPD, compared to 19 to 57% responders among Malawians. Priming for regulatory IL-10 may contribute to the smaller increase in gamma interferon responses in Malawians compared to United Kingdom subjects following BCG vaccination.
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