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Phillips, Daniel J.; Gibson, Matthew I. (2015)
Publisher: Royal Society of Chemistry
Languages: English
Types: Article
Subjects: QD
Responsive polymers have found diverse application across polymer, biomaterials, medical, sensing and engineering fields. Despite many years of study, this has focussed mainly on those polymers which undergo thermally-induced changes – either a lower or upper critical solution temperature. To rival the adaptability of Nature's macromolecules, polymers must respond in a ‘smarter’ way to other triggers such as enzymes, biochemical gradients, ion concentration or metabolites, to name a few. Here we review the concept of ‘isothermal’ responses where core thermoresponsive polymers are chemically engineered such that they undergo their useful response (such as coil-globule transition, cell uptake or cargo release) but at constant temperature. This is achieved by consideration of their phase diagram where solubility can be changed by small structural changes to the end-group, side-chain/substituents or through main chain modification/binding. The current state-of-the-art is summarised here.\ud
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1 J. F. Mano, Adv. Eng. Mater., 2008, 10, 515-527.
    • 2 M. A. C. Stuart, W. T. S. Huck, J. Genzer, M. Muller, C. Ober, M. Stamm, G. B. Sukhorukov, I. Szleifer, V. V. Tsukruk, M. Urban, F. Winnik, S. Zauscher, I. Luzinov and S. Minko, Nat. Mater., 2010, 9, 101-113.
    • 3 F. Liu and M. W. Urban, Prog. Polym. Sci., 2010, 35, 3-23.
    • 4 X. Yan, F. Wang, B. Zheng and F. Huang, Chem. Soc. Rev., 2012, 41, 6042-6065.
    • 5 R. Tong, L. Tang, L. Ma, C. Tu, R. Baumgartner and J. Cheng, Chem. Soc. Rev., 2014, 43, 6982-7012.
    • 6 P. Schattling, F. D. Jochum and P. Theato, Polym. Chem., 2014, 5, 25-36.
    • 7 M. Rubinstein and R. H. Corby, Polymer Physics, Oxford University Press, Oxford, 2003.
    • 8 E. Ruel-Gariépy and J.-C. Leroux, Eur. J. Pharm. Biopharm., 2004, 58, 409-426.
    • 9 D. Schmaljohann, Adv. Drug Delivery Rev., 2006, 58, 1655- 1670.
    • 10 J. S. Scarpa, D. D. Mueller and I. M. Klotz, J. Am. Chem. Soc., 1967, 89, 6024-6030.
    • 11 H. G. Schild, Prog. Polym. Sci., 1992, 17, 163-249.
    • 12 D. Roy, W. L. A. Brooks and B. S. Sumerlin, Chem. Soc. Rev., 2013, 42, 7214-7243.
    • 13 M.-C. Jones and J.-C. Leroux, Eur. J. Pharm. Biopharm., 1999, 48, 101-111.
    • 14 M. I. Gibson, D. Paripovic and H.-A. Klok, Adv. Mater., 2010, 22, 4721-4725.
    • 15 N. S. Ieong, K. Brebis, L. E. Daniel, R. K. O'Reilly and M. I. Gibson, Chem. Commun., 2011, 47, 11627- 11629.
    • 16 J. Wang, M. I. Gibson, R. Barbey, S.-J. Xiao and H.-A. Klok, Macromol. Rapid Commun., 2009, 30, 845-850.
    • 17 R. Barbey, L. Lavanant, D. Paripovic, N. Schüwer, C. Sugnaux, S. Tugulu and H.-A. Klok, Chem. Rev., 2009, 109, 5437-5527.
    • 18 P. S. Stayton, T. Shimoboji, C. Long, A. Chilkoti, G. Ghen, J. M. Harris and A. S. Hoffman, Nature, 1995, 378, 472- 474.
    • 19 M. W. Jones, M. I. Gibson, G. Mantovani and D. M. Haddleton, Polym. Chem., 2011, 2, 572-574.
    • 20 S. Dey, B. Kellam, M. R. Alexander, C. Alexander and F. R. A. J. Rose, J. Mater. Chem., 2011, 21, 6883-6890.
    • 21 H.-Y. Tsai, K. Vats, M. Z. Yates and D. S. W. Benoit, Langmuir, 2013, 29, 12183-12193.
    • 22 G. Chen and A. S. Hoffman, Bioconjugate Chem., 1993, 4, 509-514.
    • 23 H. Kanazawa, J. Sep. Sci., 2007, 30, 1646-1656.
    • 24 C.-W. Chang, T. H. Nguyen and H. D. Maynard, Macromol. Rapid Commun., 2010, 31, 1691-1695.
    • 25 J. E. Chung, M. Yokoyama, M. Yamato, T. Aoyagi, Y. Sakurai and T. Okano, J. Controlled Release, 1999, 62, 115-127.
    • 26 Y. Saaka, R. C. Deller, A. Rodger and M. I. Gibson, Macromol. Rapid Commun., 2012, 33, 779-784.
    • 27 E. W. Edwards, M. Chanana, D. Wang and H. Möhwald, Angew. Chem., Int. Ed., 2008, 47, 320-323.
    • 28 S. Salmaso, P. Caliceti, V. Amendola, M. Meneghetti, J. P. Magnusson, G. Pasparakis and C. Alexander, J. Mater. Chem., 2009, 19, 1608-1615.
    • 29 S. R. Abulateefeh, S. G. Spain, K. J. Thurecht, J. W. Aylott, W. C. Chan, M. C. Garnett and C. Alexander, Biomater. Sci., 2013, 1, 434-442.
    • 30 J. Akimoto, M. Nakayama, K. Sakai and T. Okano, Biomacromolecules, 2009, 10, 1331-1336.
    • 31 J. Akimoto, M. Nakayama, K. Sakai and T. Okano, Mol. Pharm., 2010, 7, 926-935.
    • 32 D. E. Meyer, B. C. Shin, G. A. Kong, M. W. Dewhirst and A. Chilkoti, J. Controlled Release, 2001, 74, 213-224.
    • 33 M. R. Dreher, W. Liu, C. R. Michelich, M. W. Dewhirst and A. Chilkoti, Cancer Res., 2007, 67, 4418-4424.
    • 34 S. R. Abulateefeh, S. G. Spain, J. W. Aylott, W. C. Chan, M. C. Garnett and C. Alexander, Macromol. Biosci., 2011, 11, 1722-1734.
    • 35 N. Tirelli, Curr. Opin. Colloid Interface Sci., 2006, 11, 210- 216.
    • 36 D. Janigro, Epilepsia, 2012, 53, 26-34.
    • 37 M. M. Chaumeil, J. Valette, C. Baligand, E. Brouillet, P. Hantraye, G. Bloch, V. Gaura, A. Rialland, P. Krystkowiak, C. Verny, P. Damier, P. Remy, A.-C. Bachoud-Levi, P. Carlier and V. Lebon, J. Cereb. Blood Flow Metab., 2012, 32, 771-779.
    • 38 G. Perry, R. J. Castellani, K. Hirai and M. A. Smith, J. Alzheimer's Dis., 1998, 1, 45-55.
    • 39 K. Sugamura and J. J. F. Keaney, Free Radical Biol. Med., 2011, 51, 978-992.
    • 40 S. M. Dhanasekaran, T. R. Barrette, D. Ghosh, R. Shah, S. Varambally, K. Kurachi, K. J. Pienta, M. A. Rubin and A. M. Chinnaiyan, Nature, 2001, 412, 822-826.
    • 41 P. Meers, Adv. Drug Delivery Rev., 2001, 53, 265-272.
    • 42 J. D. Raffetto and R. A. Khalil, Biochem. Pharmacol., 2008, 75, 346-359.
    • 43 C. d. l. H. Alarcon, S. Pennadam and C. Alexander, Chem. Soc. Rev., 2005, 34, 276-285.
    • 44 B. P. Timko, T. Dvir and D. S. Kohane, Adv. Mater., 2010, 22, 4925-4943.
    • 45 H. Priya James, R. John, A. Alex and K. R. Anoop, Acta Pharm. Sin. B, 2014, 4, 120-127.
    • 46 R. W. Lenz and R. H. Marchessault, Biomacromolecules, 2004, 6, 1-8.
    • 47 M. I. Gibson and N. R. Cameron, J. Polym. Sci., Part A: Polym. Chem., 2009, 47, 2882-2891.
    • 48 M. A. Hillmyer and W. B. Tolman, Acc. Chem. Res., 2014, 47, 2390-2396.
    • 49 J. Undin, A. Finne-Wistrand and A.-C. Albertsson, Biomacromolecules, 2014, 15, 2800-2807.
    • 50 D. P. Sanders, D. J. Coady, M. Yasumoto, M. Fujiwara, H. Sardon and J. L. Hedrick, Polym. Chem., 2014, 5, 327- 329.
    • 51 G. G. Hedir, C. A. Bell, N. S. Ieong, E. Chapman, I. R. Collins, R. K. O'Reilly and A. P. Dove, Macromolecules, 2014, 47, 2847-2852.
    • 52 S. T. Reddy, A. Rehor, H. G. Schmoekel, J. A. Hubbell and M. A. Swartz, J. Controlled Release, 2006, 112, 26-34.
    • 53 P. Carampin, E. Lallana, J. Laliturai, S. C. Carroccio, C. Puglisi and N. Tirelli, Macromol. Chem. Phys., 2012, 213, 2052-2061.
    • 54 Y. Lee, H. Mo, H. Koo, J.-Y. Park, M. Y. Cho, G.-w. Jin and J.-S. Park, Bioconjugate Chem., 2006, 18, 13-18.
    • 55 C.-C. Chang and T. Emrick, Macromolecules, 2014, 47, 1344-1350.
    • 56 D. J. Phillips and M. I. Gibson, Antioxid. Redox Signaling, 2014, 21, 786-803.
    • 57 D. J. Phillips and M. I. Gibson, Chem. Commun., 2012, 48, 1054-1056.
    • 58 D. J. Phillips and M. I. Gibson, Biomacromolecules, 2012, 13, 3200-3208.
    • 59 J. Y. Choi, J. Y. Kim, H. J. Moon, M. H. Park and B. Jeong, Macromol. Rapid Commun., 2014, 35, 66-70.
    • 60 V. Coessens, T. Pintauer and K. Matyjaszewski, Prog. Polym. Sci., 2001, 26, 337-377.
    • 61 M. A. Tasdelen, M. U. Kahveci and Y. Yagci, Prog. Polym. Sci., 2011, 36, 455-567.
    • 62 C. Boyer, M. H. Stenzel and T. P. Davis, J. Polym. Sci., Part A: Polym. Chem., 2011, 49, 551-595.
    • 63 J. E. Chung, M. Yokoyama, T. Aoyagi, Y. Sakurai and T. Okano, J. Controlled Release, 1998, 53, 119-130.
    • 64 Y. Xia, N. A. D. Burke and H. D. H. Stöver, Macromolecules, 2006, 39, 2275-2283.
    • 65 X. Jiang and B. Zhao, J. Polym. Sci., Part A: Polym. Chem., 2007, 45, 3707-3721.
    • 66 Q. Duan, Y. Miura, A. Narumi, X. Shen, S.-I. Sato, T. Satoh and T. Kakuchi, J. Polym. Sci., Part A: Polym. Chem., 2006, 44, 1117-1124.
    • 67 W. Steinhauer, R. Hoogenboom, H. Keul and M. Moeller, Macromolecules, 2010, 43, 7041-7047.
    • 68 F. D. Jochum, L. zur Borg, P. J. Roth and P. Theato, Macromolecules, 2009, 42, 7854-7862.
    • 69 S. Carter, B. Hunt and S. Rimmer, Macromolecules, 2005, 38, 4595-4603.
    • 70 J. Shepherd, P. Sarker, K. Swindells, I. Douglas, S. MacNeil, L. Swanson and S. Rimmer, J. Am. Chem. Soc., 2010, 132, 1736-1737.
    • 71 P. Sarker, J. Shepherd, K. Swindells, I. Douglas, S. MacNeil, L. Swanson and S. Rimmer, Biomacromolecules, 2010, 12, 1-5.
    • 72 S. Dai, P. Ravi and K. C. Tam, Soft Matter, 2008, 4, 435- 449.
    • 73 X. Yin, A. S. Hoffman and P. S. Stayton, Biomacromolecules, 2006, 7, 1381-1385.
    • 74 M. J. Summers, D. J. Phillips and M. I. Gibson, Chem. Commun., 2013, 49, 4223-4225.
    • 75 D. J. Phillips, J. P. Patterson, R. K. O'Reilly and M. I. Gibson, Polym. Chem., 2014, 5, 126-131.
    • 76 D. J. Phillips, I. Prokes, G.-L. Davies and M. I. Gibson, ACS Macro Lett., 2014, 3, 1225-1229.
    • 77 N. C. Andrews, N. Engl. J. Med., 1999, 341, 1986- 1995.
    • 78 H. Feil, Y. H. Bae, J. Feijen and S. W. Kim, Macromolecules, 1993, 26, 2496-2500.
    • 79 M. M. Ali and H. D. H. Stöver, Macromolecules, 2004, 37, 5219-5227.
    • 80 C. Diehl and H. Schlaad, Macromol. Biosci., 2009, 9, 157- 161.
    • 81 F. D. Jochum and P. Theato, Macromolecules, 2009, 42, 5941-5945.
    • 82 T. Shimoboji, E. Larenas, T. Fowler, S. Kulkarni, A. S. Hoffman and P. S. Stayton, Proc. Natl. Acad. Sci. U. S. A., 2002, 99, 16592-16596.
    • 83 Y.-J. Liu, A. Pallier, J. Sun, S. Rudiuk, D. Baigl, M. Piel, E. Marie and C. Tribet, Soft Matter, 2012, 8, 8446-8455.
    • 84 F. D. Jochum, F. R. Forst and P. Theato, Macromol. Rapid Commun., 2010, 31, 1456-1461.
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