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Amey, Joanna S.; O'Reilly, Andrias O.; Burton, Mark J.; Puinean, Alin M.; Mellor, Ian R.; Duce, Ian R.; Field, Linda M.; Wallace, B.A.; Williamson, Martin S.; Davies, T.G. Emyr (2015)
Publisher: Wiley
Journal: Febs Letters
Languages: English
Types: Article
Subjects: RACE, Rapid Amplification of cDNA ends, DDT, dichlorodiphenyltrichloroethane, kb, kilobase(s) or 1000 base pairs, NCBI, The National Center for Biotechnology Information, Evolution, BLAST, basic local alignment search tool, PCR, polymerase chain reaction, Voltage-gated sodium channel, TM, trans membrane, Article, MYA, million years ago, bcs, TTX, tetrodotoxin, bp, base pair, Nav, voltage-gated sodium channel, cDNA, DNA complementary to RNA, Tetrodotoxin, RNA, ribonucleic acid, Aphid
We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel’s novel selectivity filter motif (DENS instead of the usual DEKA found in other eukaryotes) may result in a loss of sodium selectivity, as indicated experimentally in mutagenised Drosophila channels.

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