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Al-Shammari, AA; Gaffney, EA; Egginton, S (2014)
Publisher: Springer International
Languages: English
Types: Part of book or chapter of book

Classified by OpenAIRE into

mesheuropmc: lipids (amino acids, peptides, and proteins)
The ability to characterise functional capillary supply (FCS) plays a key role in developing effective therapeutic interventions for numerous pathological conditions, such as chronic ischaemia in skeletal or cardiac muscle. Detailed tissue geometry, such as muscle fibre size, has been incorporated into indices of FCS by considering the distribution of Voronoi tessellations (‘capillary domains’) generated from vessel locations in a plane perpendicular to muscle fibre orientation, implicitly assuming that each Voronoi polygon represents the area of supply of its enclosed capillary. However, to assess the capacity of FCS in muscle, we are naturally led to use a modelling framework that can account for the local anatomic and metabolic heterogeneities of muscle fibres. Such a framework can be used to explore the validity of the Voronoi polygon representation of FCS regions while also providing a general platform for robust predictions of FCS.
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    • 2. A.A. Al-Shammari, E.A. Gaffney and S. Egginton (2014), Modelling oxygen capillary supply capacity in mixed muscles: capillary domains revisited, Journal of Theoretical Biology, Submitted.
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    • 14. World Health Organization, The top 10 causes of death. Retrieved December 22, 2013 from http://www.who.int/mediacentre/factsheets/fs310/en/
    • 15. R.C.I. Wu¨st, S.L. Gibbings and H. Degens (2009). Fiber capillary supply related to fiber size and oxidative capacity in human and rat skeletal muscle, P. Liss, P. Hansell, D.F. Bruley and D.K. Harrison (eds.), Oxygen Transport to Tissue XXX , vol. 645 of Advances in Experimental Medicine and Biology, pp. 7580.
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