Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Mosconi, P.; Antes, G.; Barbareschi, G.; Burls, A.; Demotes-Mainard, J.; Chalmers, I.; Colombo, C.; Garattini, S.; Gluud, C.; Gyte, G.; Mcllwain, C.; Penfold, M.; Post, N.; Satolli, R.; Valetto, M. R.; West, B.; Wolff, S. (2016)
Publisher: Springer Nature
Journal: Trials
Languages: English
Types: Article
Subjects: Independent clinical trial, Medicine (miscellaneous), Patients, Lay people, Health research, Information, Access to information, Research, Pharmacology (medical), RA
BACKGROUND: The ECRAN (European Communication on Research Awareness Needs) project was initiated in 2012, with support from the European Commission, to improve public knowledge about the importance of independent, multinational, clinical trials in Europe. \ud \ud METHODS: Participants in the ECRAN consortium included clinicians and methodologists directly involved in clinical trials; researchers working in partnership with the public and patients; representatives of patients; and experts in science communication. We searched for, and evaluated, relevant existing materials and developed additional materials and tools, making them freely available under a Creative Commons licence. \ud \ud RESULTS: The principal communication materials developed were: 1. A website ( http://ecranproject.eu ) in six languages, including a Media centre section to help journalists to disseminate information about the ECRAN project 2. An animated film about clinical trials, dubbed in the 23 official languages of the European Community, and an interactive tutorial 3. An inventory of resources, available in 23 languages, searchable by topic, author, and media type 4. Two educational games for young people, developed in six languages 5. Testing Treatments interactive in a dozen languages, including five official European Community languages 6. An interactive tutorial slide presentation testing viewers' knowledge about clinical trials \ud \ud CONCLUSIONS: Over a 2-year project, our multidisciplinary and multinational consortium was able to produce, and make freely available in many languages, new materials to promote public knowledge about the importance of independent and international clinical trials. Sustained funding for the ECRAN information platform could help to promote successful recruitment to independent clinical trials supported through the European Clinical Research Infrastructure Network.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. ECRIN European Clinical Research Infrastructure Network. http://www.ecrin. org. Accessed 9 January 2016.
    • 2. European Parliament. Clinical trials: clearer rules, better protection for patients. 2014 www.europarl.europa.eu/news/en/news-room/content/20140331IPR41186/ html/Clinical-trials-clearer-rules-better-protection-for-patients. Accessed 9 January 2016.
    • 3. Westra AE, Bos W, Cohen AF. Clinical trials regulation. Needs a few tweaks before implementation. BMJ. 2014;348:g3710.
    • 4. Ellis PM, Butow PN, Tattersall MH, Dunn SM, Houssami N. Randomized clinical trials in oncology: understanding and attitudes predict willingness to participate. J Clin Oncol. 2001;19(15):3554-61.
    • 5. Dear RF, Barratt AL, Askie LM, Butow PN, McGeechan K, Crossing S, et al. Impact of a cancer clinical trials web site on discussions about trial participation: a cluster randomized trial. Ann Oncol. 2012;23(7):1912-8.
    • 6. Fayter D, McDaid C, Eastwood A. A systematic review highlights threats to validity in studies of barriers to cancer trial participation. J Clin Epidemiol. 2007;60(10):990-1001.
    • 7. Jenkins V, Farewell D, Batt L, Maughan T, Branston L, Langridge C, et al. The attitudes of 1066 patients with cancer towards participation in randomised clinical trials. Br J Cancer. 2010;103(12):1801-7.
    • 8. O'Connell D, Mosconi P. An active role for patients in clinical research? Drug Dev Res. 2006;67:188-92.
    • 9. Stewart RJ, Caird J, Oliver K, Oliver S. Patients' and clinicians' research priorities. Health Expect. 2011;14(4):439-48.
    • 10. Joffe S, Cook EF, Cleary PD, Clark JW, Weeks JC. Quality of informed consent in cancer clinical trials: a cross-sectional survey. Lancet. 2001;358(9295):1772-7.
    • 11. Comis RL, Miller JD, Aldigé CR, Krebs L, Stoval E. Public attitudes toward participation in cancer clinical trials. J Clin Oncol. 2003;21:830-5.
    • 12. Liberati A. Need to realign patient-oriented and commercial and academic research. The Lancet. 2011. 378(9805):1777-8.
    • 13. Macleod MR, Michie S, Roberts I, Dirnagl U, Chalmers I, Ioannidis JPA, et al. Biomedical research: increasing value, reducing waste. Lancet. 2014; 383(9912):101-4.
    • 14. Chalmers I, Bracken MB, Djulbegovic B, Garattini S, Grant J, Gülmezoglu AM, et al. How to increase value and reduce waste when research priorities are set. Lancet. 2014;383(9912):156-65.
    • 15. Ioannidis JPA, Greenland S, Hlatky MA, Khoury MJ, Macleod MR, Moher D, et al. Increasing value and reducing waste in research design, conduct, and analysis. Lancet. 2014;383(9912):166-75.
    • 16. GVK Bio manipulated clinical trials of generic drugs: Reports. http:// economictimes.indiatimes.com/industry/healthcare/biotech/ pharmaceuticals/gvk-bio-manipulated-clinical-trials-of-generic-drugs-reports/ articleshow/45385764.cms. Accessed 9 January 2016.
    • 17. EATG, The European AIDS Treatment Group. http://www.eatg.org/. Accessed 9 January 2016.
    • 18. CCNet, Cochrane Consumer Network. http://consumers.cochrane.org/ healthcare-users-cochrane. Accessed 9 January 2016.
    • 19. Mosconi P, Colombo C, Satolli R, Liberati A. PartecipaSalute, an Italian project to involve lay people, patients' associations and scientific-medical representatives in the health debate. Health Expect. 2007;10:194-204.
    • 20. Sail along with James Lind! http://www.ecranproject.eu/en/content/sail-alongjames-lind. Accessed 9 January 2016.
    • 21. Discover clinical trials. http://www.ecranproject.eu/en/content/discoverclinical-trials. Accessed 9 January 2016.
    • 22. Evans I, Thornton H, Chalmers I. Testing Treatments. Better research for better healthcare. London: Pinter & Martin Ltd; 2006.
    • 23. Testing Treatments interactive. http://www.testingtreatments.org. Accessed 9 January 2016.
    • 24. Chen Y, Chalmers I, on behalf of the TTi Editorial Alliance. Testing Treatments interactive (TTi): helping to equip the public to promote better research for better health care. J Evidence-Based Med. 2015;8:98-102. doi:10.111/jebm.12155.
    • 25. Testing Treatments. http://www.ecranproject.eu/en/content/testing-treatments. Accessed 9 January 2016.
    • 26. Mediacenter. http://www.ecranproject.eu/en/content/mediacenter. Accessed 9 January 20165.
    • 27. Languages of the European Union. http://en.wikipedia.org/wiki/Languages_ of_the_European_Union. Accessed 9 January 2016.
    • 28. Europe open letter education. http://www.ecranproject.eu/en/content/ europe-open-letter-education. Accessed 9 January 2016.
    • 29. Al-Shahi Salman R, Beller E, Kagan J, Hemminki E, Phillips RS, Savulescu J, et al. Increasing value and reducing waste in biomedical research regulation and management. Lancet. 2014;383(9912):176-85.
    • 30. Chan A-W, Song F, Vickers A, Jefferson T, Dickersin K, Gøtzsche PC, et al. Increasing value and reducing waste: addressing inaccessible research. Lancet. 2014;383(9913):257-66.
    • 31. Glasziou P, Altman DG, Bossuyt P, Boutron I, Clarke M, Julious S, et al. Reducing waste from incomplete or unusable reports of biomedical research. Lancet. 2014;383(9913):267-76.
    • 32. Richards T, Montori VM, Godlee F, Lapsley P, Paul D. Let the patient revolution begin. BMJ. 2013;346:f2614.
  • No related research data.
  • No similar publications.

Share - Bookmark

Funded by projects

  • EC | ECRAN

Cite this article