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Brown, Katherine; Tarlinton, Rachael E. (2016)
Publisher: Blackwell
Languages: English
Types: Article

Classified by OpenAIRE into

mesheuropmc: viruses
In the late 1960s and early 1970s, an outbreak of lymphoma and leukaemia in gibbons (Hylobatidae), attributed to the retrovirus gibbon ape leukaemia virus (GALV), was widely reported in the literature. The virus was identified in captive gibbon colonies in Thailand, the USA and Bermuda.The virus is a known cell culture contaminant and, in particular, research into HIV can be impeded by expression of GALV particles in HIV permissive cell lines.In this review, we bring together published work, laboratory records from early GALV research, correspondence about the transportation of gibbons during the 1960s and 1970s, phylogenetic analyses, laboratory screening and zoological records for the first time, to discover more about the origin and transmission of GALV.\ud Based on this evidence, we suggest that GALV may have been transmitted to gibbons as an iatrogenic event and was never widespread. Instead, all infected gibbons were probably transported from the site of the original outbreak, housed with gibbons from this site or infected with material derived from gibbons from this site.\ud We also propose that GALV is not an ongoing pathogen of captive gibbons.
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    • Andréoletti, L., Réveil, B., Moret, H., Brodard, V., Philbert, F., Tabary, T., Cohen, J.H.M., 2007. Significant genetic and antigenic variability within the env gene of systemic human immunodeficiency virus type 1 group O populations during the natural course of a heterosexual infection: a pilot study. Journal of Clinical Microbiology 45, 1319-1321.
    • Bancroft, W.H., Snitbhan, R., Rozmiarek, H., Tingapalapong, M., 1975. Experimental Infection of Gibbons with a Group B Arbovirus, in: US Army Medical Component (Ed.), SEATO Medical Research Laboratory Annual Progress Reports.
    • Berkson, G., 1968. Ko Klet Kaeo: Habitat description in: US Army Medical Component (Ed.), SEATO Medical Research Laboratory Annual Progress Reports.
    • Brown, K., Emes, R.D., Tarlinton, R.E., 2014. Multiple Groups of Endogenous Epsilon-Like Retroviruses Conserved across Primates. Journal of Virology 88, 12464-12471.
    • Burtonboy, G., Delferriere, N., Mousset, B., Heusterspreute, M., 1993. Isolation of a C-type retrovirus from an HIV infected cell line. Arch Virol 130, 289-300.
    • Cadigan, M.A.J., Chaicumpa, V., Puhomchareon, S., 1967. Effect of P. falciparum infection on Serum Biochemistry Values of the Gibbon in: US Army Medical Component (Ed.), SEATO Medical Research Laboratory Annual Progress Reports.
    • Callahan, R., Meade, C., Todaro, G.J., 1979. Isolation of an endogenous type C virus related to the infectious primate type C viruses from the Asian rodent Vandeleuria oleracea. Journal of Virology 30, 124-131.
    • Chan, E., Peters, W.P., Sweet, R.W., Ohno, T., Kufe, D.W., Spiegelman, S.O.L., Gallo, R.C., Gallagher, R.E., 1976. Characterisation of a virus (HL23V) isolated from cultured acute myelogenous leukaemic cells. Nature 260, 266-268.
    • De Paoli, A., Garner, F.M., 1968. Acute lymphocytic leukemia in a white-cheeked gibbon.
    • (Hylobates concolor). Cancer Res 28, 2559-2561.
    • De Paoli, A., Noll, W.W., Johnsen, D.O., 1971. Leukaemia in the Gibbon., in: US Army Medical Component (Ed.), SEATO Medical Research Laboratory Annual Progress Reports.
    • Diggs, C.L., Pavanand, K., 1969. P. falciparum in small rodents, in: US Army Medical Component (Ed.), SEATO Medical Research Laboratory Annual Progress Reports.
    • DiGiacomo, R.F., 1967. Burkitt's lymphoma in a white-handed gibbon (Hylobates lar).
    • Cancer Res 27, 1178-1179.
    • Eiden, M.V., Taliaferro, D.L., 2011. Emerging Retroviruses and Cancer, in: Dudley, J. (Ed.), Retroviruses and Insights into Cancer. Springer, New York.
    • Gallagher, R., Gallo, R., 1975. Type C RNA tumor virus isolated from cultured human acute myelogenous leukemia cells. Science 187, 350-353.
    • Guindon, S., Dufayard, J.-F., Lefort, V., Anisimova, M., Hordijk, W., Gascuel, O., 2010. New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0. Systematic Biology 59, 307-321.
    • Hayward, A., Grabherr, M., Jern, P., 2013. Broad-scale phylogenomics provides insights into retrovirus-host evolution. Proceedings of the National Academy of Sciences 110, 20146- 20151.
    • Katoh, K., Misawa, K., Kuma, K., Miyata, T., 2002. MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Research 30, 3059- 3066.
    • Kawakami, T., Buckley, P.M., McDowell, T.S., DePaoli, A., 1973. Antibodies to simian Ctype virus antigen in sera of gibbons (Hylobates sp.). Nat New Biol 246, 105-107.
    • Kawakami, T.G., Buckley, P.M., dePaoli, A., Noll, W., Bustad, L.K., 1975. Studies on the prevalence of type C virus associated with gibbon hematopoietic neoplasms. Bibl Haematol, 385-389.
    • Kawakami, T.G., Huff, S.D., Buckley, P.M., Dungworth, D.L., Synder, S.P., Gilden, R.V., 1972. C-type virus associated with gibbon lymphosarcoma. Nat New Biol 235, 170-171.
    • Levy, J.A., Hoffman, A.D., Kramer, S.M., Landis, J.A., Shimabukuro, J.M., Oshiro, L.S., 1984. Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.
    • Science 225, 840-842.
    • Lieber, M.M., Sherr, C.J., Todaro, G.J., Benveniste, R.E., Callahan, R., Coon, H.G., 1975.
    • Isolation from the Asian mouse Mus caroli of an endogenous type C virus related to infectious primate type C viruses. Proceedings of the National Academy of Sciences 72, 2315-2319.
    • Lingeman, C.H., Reed, R.E., Garner, F.M., 1969. Spontaneous hematopoietic neoplasms of nonhuman primates. Review, case report, and comparative studies. National Cancer Institute monograph 32, 157-170.
    • Marshall, J.T., 1974. Study of Vertebrate Reservoirs of Disease in: US Army Medical Component (Ed.), SEATO Medical Research Laboratory Annual Progress Reports.
    • Marshall, J.T., 1975. Vertebrate Reservoirs of Disease in: US Army Medical Component (Ed.), SEATO Medical Research Laboratory Annual Progress Reports.
    • Nowak, M., 1999. in: Nowak, M. (Ed.), Walker's Mammals of the World. Johns Hopkins University Press, Baltimore, pp. 1548-1549.
    • Okabe, H., Gilden, R.V., Hatanaka, M., Stephenson, J.R., Gallagher, R.E., Gallo, R.C., Tronick, S.R., Aaronson, S.A., 1976. Immunological and biochemical characterisation of type C viruses isolated from cultured human AML cells. Nature 260, 264-266.
    • Parent, I., Qin, Y., Vandenbroucke, A.T., Walon, C., Delferrière, N., Godfroid, E., Burtonboy, G., 1998. Characterization of a C-type retrovirus isolated from an HIV infected cell line: complete nucleotide sequence. Archives of Virology 143, 1077-1092.
    • Rice, P., Longden, I., Bleasby, A., 2000. EMBOSS: The European Molecular Biology Open Software Suite. Trends in Genetics 16, 276-277.
    • Siegal-Willott, J.L., Jensen, N., Kimi, D., Taliaferro, D., Blankenship, T., Malinsky, B., Murray, S., Eiden, M.V., Xu, W., 2015. Evaluation of captive gibbons (Hylobates spp., Nomascus spp., Symphalangus spp.) in North American Zoological Institutions for Gibbon Ape Leukemia Virus (GALV). J Zoo Wildl Med 46, 27-33.
    • Simmons, G., Clarke, D., McKee, J., Young, P., Meers, J., 2014. Discovery of a Novel Retrovirus Sequence in an Australian Native Rodent (Melomys burtoni): A Putative Link between Gibbon Ape Leukemia Virus and Koala Retrovirus. PLoS ONE 9, e106954.
    • Slater, G., Birney, E., 2005. Automated generation of heuristics for biological sequence comparison. BMC Bioinformatics 6, 31.
    • Smith, P.C., Yuill, T.M., Buchanan, R.D., 1968. Effect of P. falciparum infection on Serum Biochemistry Values of the Gibbon in: US Army Medical Component (Ed.), SEATO Medical Research Laboratory Annual Progress Reports.
    • Smith, T.F., Waterman, M.S., 1981. Identification of common molecular subsequences.
    • Journal of Molecular Biology 147, 195-197.
    • Takeuchi, Y., McClure, M.O., Pizzato, M., 2008. Identification of Gammaretroviruses Constitutively Released from Cell Lines Used for Human Immunodeficiency Virus Research.
    • Journal of Virology 82, 12585-12588.
    • Tarlinton, R., Meers, J., Young, P., 2008. Endogenous retroviruses. Cell. Mol. Life Sci. 65, 3413-3421.
    • Tarlinton, R.E., Meers, J., Young, P.R., 2006. Retroviral invasion of the koala genome.
    • Nature 442, 79-81.
    • Theilen, G.H., Gould, D., Fowler, M., Dungworth, D.L., 1971. C-type virus in tumor tissue of a woolly monkey (Lagothrix spp.) with fibrosarcoma. J Natl Cancer Inst 47, 881-889.
    • Todaro, G.J., Lieber, M.M., Benveniste, R.E., Sherr, C.J., 1975. Infectious primate type C viruses: Three isolates belonging to a new subgroup from the brains of normal gibbons.
    • Virology 67, 335-343.
    • Voevodin, A.F., Marx, P.A., 2009. Simian Virology. Blackwell Publishing, Iowa, USA.
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