LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Abay, T.; Kyriacou, P. A. (2015)
Publisher: IEEE
Languages: English
Types: Article
Subjects: QA

Classified by OpenAIRE into

mesheuropmc: sense organs
In the last decades Photoplethysmography (PPG) has been used as noninvasive technique for monitoring arterial oxygen saturation by Pulse Oximetry (PO), whereas Near Infrared Spectroscopy (NIRS) has been employed for monitoring tissue blood perfusion. While NIRS offers more parameters to evaluate oxygen delivery and consumption in deep tissues, PO only assesses the state of oxygen delivery. For a broader assessment of blood perfusion, this paper explores the utilization of dual-wavelength PPG by using the pulsatile (AC) and continuous (DC) PPG for the estimation of arterial oxygen saturation (SpO2) by conventional PO. Additionally, the Beer-Lambert law is applied to the DC components only for the estimation of changes in deoxy-hemoglobin (HHb), oxy-hemoglobin (HbO2) and total hemoglobin (tHb) as in NIRS. The system was evaluated on the forearm of 21 healthy volunteers during induction of venous occlusion (VO) and total occlusion (TO). A reflectance PPG probe and NIRS sensor were applied above the brachioradialis, PO sensors were applied on the fingers, and all the signals were acquired simultaneously. While NIRS and forearm SpO2 indicated VO, SpO2 from the finger did not exhibit any significant drop from baseline. During TO all the indexes indicated the change in blood perfusion. HHb, HbO2 and tHb changes estimated by PPG presented high correlation with the same parameters obtained by NIRS during VO (r2=0.960, r2=0.821 and r2 =0.974 respectively) and during TO (r2=0.988, r2=0.940 and r2=0.938 respectively). The system demonstrated the ability to extract valuable information from PPG signals for a broader assessment of tissue blood perfusion.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • [1] M. Siegemund, J. van Bommel and C. Ince, "Assessment of regional tissue oxygenation," Intensive Care Medicine, vol. 25, pp. 1044-1060, 1999.
    • [2] A. Lima and J. Bakker, "Noninvasive monitoring of peripheral perfusion," Intensive Care Medicine, vol. 31, pp. 1316-1326, 2005.
    • [3] Y. Sakr, "Techniques to assess tissue oxygenation in the clinical setting," Transfusion and Apheresis Science, vol. 43, no. 2010, pp. 79-94, 2010.
    • [4] M. Hickey, N. Samuels, N. Randive, R. M. Langford and P. A. Kyriacou, "A new fibre optic pulse oximeter probe for monitoring splanchnic organ arterial blood oxygen saturation," Computer Methods and Programs in Biomedicine, vol. 108, no. 3, pp. 883-888, 2011.
    • [5] M. E. van Genderen, J. van Bommel and A. Lima, "Monitoring peripheral perfusion in critically ill patients at the bedside," Current Opinion in Critical Care, vol. 8, no. 3, pp. 273-379, 2012.
    • [6] P. A. Kyriacou, "Direct pulseoximetry within the esophagus, on the surface of abdominal viscera, and on free flaps," Anesthesia and Analgesia, vol. 117, no. 4, pp. 824-833, 2013.
    • [7] T. Zaman, P. K. Pal and P. A. Kyriacou, "Pilot investigation of DIEP free flap perfusion utilizing a multi-wavelength non-invasive optical sensor," British Journal of Anaesthesia, vol. 110, no. 5, pp. 884-885, 2013.
    • [8] J. T. Moyle, Pulse Oximetry, London: BMJ Books, 2002.
    • [9] P. A. Kyriacou, "Pulse oximetry in the oesophagus," Physiological Measurement, vol. 27, no. 1, pp. R1-R35, 2006.
    • [10] E. D. Chan, M. M. Chan and M. M. Chan, "Pulse Oximetry: Understanding its basic principles facilitates appreciation of its limitation," Respiratory Medicine, vol. 107, no. 6, pp. 789-799, 2013.
    • [11] A. A. Kamal, J. B. Harness, G. Irving and A. J. Mearns, "Skin photoplethysmography - a review," Computer Methods and Programs in Biomedicine, vol. 28, no. 4, pp. 257-269, 1989.
    • [12] J. E. Sinex, "Pulse oximetry: principles and limitations," American Journal of Emergency Medicine, vol. 17, no. 1, pp. 59-66, 1999.
    • [13] A. Reisner, P. A. Shaltis, D. McCombie and H. H. Asada, "Utility of photoplethysmography in circulatory monitoring," Anesthesiology, vol. 108, no. 5, pp. 950-958, 2008.
    • [14] J. Allen, "Photoplethysmography and its application in clinical physiological measurement," Physiological Measurements, vol. 28, pp. R1-R39, 2007.
    • [15] A. P. Lima, P. Beelen and J. Bakker, "Use of peripheral perfusion index derived from the pulse oxmetry signal as a noninvasive indicator of perfusion," Critical Care Medicine, vol. 30, no. 6, pp. 1210-1213, 2002.
    • [16] P. Zaramella, F. Freato, V. Quaresima, M. Ferrari , A. Vianello, D. Giongo, L. Conte and L. Chaindetti, "Foot pulse Oximeter perfusion index correlated with calf muscle perfusion mesured by near-infrared spectroscpy in healthy neonates," Journal of Perinatology, vol. 25, no. 6, pp. 417-422, 2005.
    • [17] K. Shelley, "Photoplethysmography: beyond the calculation of arterial oxygen saturation and heart rate," Anaesthesia & Analgesia, vol. 105, no. 6, pp. S31 - S36, 2007.
    • [18] R. Sahni, "Noninvasive monitoring by photoplethysmography," Clinics in Perinatology, vol. 39, no. 3, pp. 573-583, 2012.
    • [19] M. van Genderen, S. A. Bartels, A. Lima, R. Bezemer, C. Ince, J. Bakker and J. van Bommel, "Peripheral perfusion index as an early predictor for central hypovolemia in awake healthy volunteers," Anesthesia and Analgesia, vol. 116, no. 2, pp. 351-356, 2013.
    • [20] V. Kamat, "Pulse Oximetry," Indian Journal of Anaesthesia, vol. 46, no. 4, pp. 261-268, 2002.
    • [21] A. Jubran, "Pulse Oximetry," in Applied Physiology in Intensive Care Medicine, G. Hedenstierna, J. Mancebo, L. Brochard and M. R. Pinsky, Eds., London, Springer Berlin Heidelberg, 2009, pp. 45-48.
    • [22] P. A. Kyriacou, K. Shafqat and S. K. Pal, "Pilot investigation of photoplethysmographic signals and blood oxygen saturation values during blood pressure cuff-induced hypoperfusion," Measurement, vol. 42, pp. 1001 - 1005, 2009.
    • [23] M. Shafique, P. A. Kyriacou and S. K. Pal, "investigation of photoplethysmographic signals and blood oxygen saturation values on healthy volunteers during cuff-induced hypoperfusion using a multimode PPG/SpO2 sensor," Medical and Biological Engineering and Computing, vol. 50, p. 575 583, 2012.
    • [24] P. Rolfe, "In vivo near infrared spectroscopy," Annual Reviews of Biomedical Engineering, vol. 2, pp. 715-754, 2000.
    • [25] A. Pellicer and M. del Carmen Bravo, "Near-infrared spectroscopy: a methodology - focused review," Seminar in Fetal & Neonatal Medicine, vol. 16, no. 2011, pp. 42-49, 2011.
    • [26] K. McCully and T. Hamaoka, "Near-infrared spectroscopy: what can it tell us about oxygen saturation in skeletal muscle?," Exercise and Sport Sciences Reviews, vol. 28, no. 3, pp. 123-127, 2000.
    • [27] R. Boushel and C. A. Piantadosi, "Near-infrared spectroscopy for monitoring muscle oxygenation," Acta Physiologica Scandinavica, vol. 168, no. 4, pp. 615-622, 2000.
    • [28] M. Girardis, L. Rinaldi, S. Busani , I. Flore, S. Mauro and A. Pasetto, "Muscle perfusion and oxygen consumption by near-infrared spectroscopy in septic and non-septic-shock patients," Intensive Care Medicine, vol. 29, pp. 1173-1176, 2003.
    • [29] B. Shadgan, W. D. Reid, R. Gharakhanlou, L. Stothers and J. Macnab, "Wireless near- infrared spectroscopy of skeletal muscle oxygenation and hemodynamics during exercise and ischemia," Spectroscopy, vol. 23, pp. 233-241, 2009.
    • [30] D. S. Martin, D. Z. Levett, R. Bezemer, H. E. Montgomery, M. P. Grocott and Claudwell Xtreme Everest Research Group, "The use of skeletal muscle near infrared spectroscopy and a vascular occlusion test at high altitude," High Altitude Medicine & BIology, vol. 14, no. 3, 2013.
    • [31] T. J. Galla, D. Hellekes and A. M. Feller, "Differentiation between arterial and venous vessel occlusion by simultaneous measurement with laser Doppler flowmetry and photoplethysmography," Journal of Reconstructive Microsurgery, vol. 15, no. 1, pp. 67-72, 1999.
    • [32] N. B. Hampson and C. Piantadosi, "Near-infrared monitoring of human skeletal muscle oxygenation during forearm ischemia," Journal of Applied Physiology, vol. 64, no. 6, pp. 2449-2457, 1988.
    • [33] V. Rybynok, J. M. May, K. Budidha and P. A. Kyriacou, "Design and development of a novel multi-channel photoplethysmographic research system," in IEEE Point-of-Care Healthcare Technologies, Bangalore, India, 2013.
    • [34] K. Budidha and P. A. Kyriacou, "The human ear canal: investigation of its sutability for monitoring photoplethysmographs and arterial oxygen saturation," Physiological Measurement, vol. 35, pp. 111-128, 2014.
    • [35] K. Budidha and P. A. Kyriacou, "Development of an optical probe to investigate the suitability of measuring photoplethysmographs and blood oxygen saturation from the human auditory canal," Osaka, Japan, 2013.
    • [36] H. Njoum and P. A. Kyriacou, "Investigation of finger reflectance photoplethysmography in volunteers undergoing a local sympathetic stimulation," Journal of Physics: Conference Series - Sensors & their Applications XVII, vol. 450, 2013.
    • [37] J. G. Webster, Design of pulse oximeters, 1st ed., New York, NY, USA: Taylor and Francis, 1997.
    • [38] Y. Mendelson and B. D. Ochs, "Noninvasive pulse oximetry utilizing skin reflectance photoplethysmography," IEEE Transactions on Biomedical Engineering, vol. 35, no. 10, pp. 798-805, 1988.
    • [39] M. Hickey and P. A. Kyriacou, "Optimal spacing between transmitting and receiving optical fibres in reflectance pulse oximetry," Journal of Physics - Conference Series, vol. 85, no. 1, 2007.
    • [40] Hamamatsu Photonics, "NIRO 200NX- Measurement Principles," Hamamatsu Photonics, Hamamatsu, Japan, 2013.
    • [41] S. Suzuki, S. Takasaki, T. Ozaki and Y. Kobayashi, "A tissue oxygenation monitor using NIR spatially resolved spectroscopy," in SPIE Conference on Optical Tomography and Spectroscopy of Tissue III, San Jose, California, USA, 1999.
    • [42] S. Hyttel-Sorensen, L. C. Sorensen, J. Riera and G. Greisen, "Tissue oximetry: a comparison of mean values of regional tissue saturation, reporducibility and dynamic range of four NIRS-instruments on the human forearm," Biomedic Optic Express, vol. 2, no. 11, pp. 3047-3057, 2011.
    • [43] Y. Mendelson and M. J. McGinn, "Skin reflectance pulse oximetry: in vivo measurements from the forearm and calf," Journal of Clinical Monitoring, vol. 7, pp. 7-12, 1991.
    • [44] P. D. Mannheimer, M. P. O'Neil and E. Konecny, "The influence of large subcutaneous blood vessels on pulse oximetry," Journal of Clinical Monitoring and Computing, vol. 18, no. 3, pp. 179-188, 2004.
    • [45] M. Ferrari, T. Binzoni and V. Quaresima, "Oxidative metabolism in muscle," Phylosophical Transactions of The Royal Society - Biological Sciences, vol. 352, no. 1354, pp. 677-683, 1997.
    • [46] R. Wariar, J. N. Gaffke, R. G. Haller and L. A. Bertocci, "A modular NIRS system for clinical measurement of impaired skeletal muscle oxygenation," Journal of Applied Physiology, vol. 88, pp. 315-325, 2000.
    • [47] T. J. Akl, M. A. Wilson, M. N. Ericson, E. Farquhar, G. L. Cote, “Wireless Monitoring of Liver Hemodynamics In Vivo”, PloS one, vol. 9, no. 7, e102396, 2014.
    • [48] A. Lima and J. Bakker, "Clinical monitoring of peripheral perfusion: there is more to learn," Critical Care, vol. 18, no. 1, 2014.
    • [49] R. A. De Blasi, N. Almenrader, P. Aurisicchio and M. Ferrari, "Comparison of two methods of measuring forearm oxygen oonsumption (VO2) by near infrared spectroscopy," Journal of Biomedical Optics, vol. 2, no. 2, pp. 171-175, 1997.
    • [50] W. F. Ganong, Review of Medical Physiology, East Norwalk, Connecticut, USA: Appleton & Lange, 1995. Prof P A Kyriacou was born in Cyprus in 1969. He received a BESc degree in Electrical Engineering from the University of Western Ontario, Canada, and M.Sc. and Ph.D. degree in Medical Electronics and Physics from St. Bartholomew's Medical College, University of London. He is currently a Professor of Biomedical Engineering and Associate Dean for Research and Enterprise at the School of Mathematics Computer Science and Engineering at City University London. He is also the Director of the Biomedical Engineering Research Centre. His main research activities are primarily focused upon the understanding, development, and applications of medical instrumentation and sensors to facilitate the prognosis, diagnosis and treatment of disease or the rehabilitation of patients. He has authored and co-authored over 200 publications; peer reviewed journal publications, invited chapters in books and conference proceedings.
  • No related research data.
  • No similar publications.

Share - Bookmark

Download from

Cite this article