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Mukherjee, R.; Edwards, J.; Underwood, M.A.; Bartlett, J.M.S. (2005)
Publisher: Wiley-Blackwell
Languages: English
Types: Article
Subjects: RC0254

Classified by OpenAIRE into

mesheuropmc: cardiovascular system
OBJECTIVE: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression.\ud \ud PATIENTS AND METHODS: Angiogenesis was assessed in 105 patients with either prostate cancer (79) or benign prostatic hyperplasia (BPH, 26) and these data correlated with levels of COX-2 expression in the same dataset. The mean microvessel density (MVD) was analysed as a marker of angiogenesis, using the endothelial antigen CD34 stained by immunohistochemistry.\ud \ud RESULTS: There was no difference in MVD in progressive tumour stages compared with BPH. There was a negative correlation between MVD and COX-2 expression, but the effect of increased COX-2 expression on MVD was not marked.\ud \ud CONCLUSION: These data suggest that COX-2 drives tumour spread in prostate cancer by means other than the promotion of angiogenesis.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

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