LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Barry, J.A.
Languages: English
Types: Doctoral thesis
Subjects: BF

Classified by OpenAIRE into

mesheuropmc: endocrine system diseases, nutritional and metabolic diseases, female genital diseases and pregnancy complications
Background: Polycystic ovary syndrome (PCOS) affects up to 10% of women, and is characterised by elevated testosterone (T) levels. Women with PCOS have higher scores than healthy women on a range of measures of psychological problems. Objective: To test the hypotheses that: 1/ The female fetus in a PCOS pregnancy experiences elevated T levels; 2/ T causes mood disturbance in women with PCOS. 3/women with PCOS show more signs of mood disturbance typical of symptoms of reactive hypoglycaemia than healthy controls. Design: Mainly between-groups cross-sectional studies. Also two meta-analyses. Setting: The research took place mainly in two London gynaecology clinics, University College London Hospital (UCLH) and the Royal Free Hospital, Hampstead (RFH). Some of the research was conducted online, and at three other gynaecology and fertility clinics. Participants: Participants were recruited from hospital clinics, support groups for women with PCOS, or the internet. Most participants were women aged 18-40. Outcome Measures: Testosterone; psychometric measures of mood disturbance. Results: 1/ Elevated T was found in the umbilical cord blood of the female fetus in PCOS pregnancies; 2/ Mood problems in PCOS were not directly caused by T. 3/ Women with PCOS showed higher levels of mood problems typical of hypoglycaemia than controls. Conclusions: The findings suggest the female fetus in a PCOS pregnancy may be exposed to relatively high levels of T. Mood problems in adults with PCOS are possibly caused by the direct effects of low blood glucose and indirect effects of T (e.g. obesity) than direct effects of T. Further research using the gold-standard biochemical assessment methods is required for any replications of these findings.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • Altuntas, Y., Bilir, M., Ucak, S., Gundogdu, S. (2005). Reactive hypoglycemia in lean young women with PCOS and correlations with insulin sensitivity and with beta cell function. European Journal of Obstetrics & Gynecology and Reproductive Biology, 119, 198-205.
    • Berlin, I., Grimaldi, A., Landault, C., Cesselin, F., Puech, A.J. (1994). Suspected postprandial hypoglycemia is associated with beta-adrenergic hypersensitivity and emotional distress. Journal of Clinical Endocrinology & Metabolism, 79,1428-33.
    • Bie-Olsen, L.G., Pedersen-Bjergaard, U., Kjaer, T.W., Lonsdale, M.N., Law, I., Thorsteinsson, B. (2010). Differences in cortical and pituitary activity in response to hypoglycaemia and cognitive testing in healthy men with different basal activity of the renin-angiotensin system. Journal of the Renin-Angiotensin-Aldosterone System, 11, 173-9.
    • Brand-Miller, J. Farid, N.R. and Marsh, K. (2004). The low GI guide to managing PCOS. London: Hodder & Stoughton.
    • Brun, J.F., Fedou, C., Mercier, J. (2000). Postprandial reactive hypoglycemia. Diabetes & Metabolism, 26, 337-51.
    • Choung, R.S., Locke, G.R. 3rd, Zinsmeister, A.R., Schleck, C.D., Talley, N.J. (2009). Psychosocial distress and somatic symptoms in community subjects with irritable bowel syndrome: a psychological component is the rule. American Journal of Gastroenterology, 104,1772-9.
    • Dahl, A.K., Hassing, L.B., Fransson, E.L., Pederson, N.L. (2010). Agreement between selfreported and measured height, weight, and body mass index in old age - a longitudinal study with 20 years of follow-up. Age and Aging, 39, 445-51.
    • Deary, I.J., Hepburn, D.A., MacLeod, K.M., Frier, B.M. (1993). Partitioning the symptoms of hypoglycaemia using multi-sample confirmatory factor analysis. Diabetologia, 36, 771-7.
    • Diamanti-Kandarakis, E., and Papavassiliou, A.G. (2006). Molecular mechanisms of insulin resistance in polycystic ovary syndrome. Trends in Molecular Medicine, 12, 324-32.
    • Galletly, C., Moran, L., Noakes, M., Clifton, P., Tomlinson, L., Norman, R. (2007). Psychological benefits of a high-protein, low-carbohydrate diet in obese women with polycystic ovary syndrome - a pilot study. Appetite, 49, 590-3.
    • Gold, A.E., MacLeod, K.M., Frier, B.M., Deary, I.J. (1995). Changes in Mood During Acute Hypoglycemia in Healthy Participants. Journal of Personality and Social Psychology, 68, 498-504.
    • Goodman, E., Hinden, B.R., Khandelwal, S. (2000). Accuracy of teen and parental reports of obesity and body mass index. Pediatrics, 106, 52-58.
    • Graneheim, U.H., Lundman, B. (2004). Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. Nursing Education Today, 24, 105-12
    • Grucza, R.A., Przybeck, T.R., Cloninger, C.R. (2007). Prevalence and correlates of binge eating disorder in a community sample. Comprehensive Psychiatry, 48,124-31
    • Hepburn, D.A., Deary, I.J., MacLeod, K.M., Frier, B.M. (1994). Structural equation modelling of symptoms, awareness and fear of hypoglycemia, and personality in patients with insulin-treated diabetes. Diabetes Care. 17, 1273-80.
    • Herriot , A.M., Whitcroft, S., Jeanes, Y. (2008). A retrospective audit of patients with polycystic ovary syndrome: the effects of a reduced glycaemic load diet. Journal of Himelein, M.J., Thatcher, S.S. (2006). Polycystic ovary syndrome and mental health: A review. Obstetrical & Gynecological Survey, 61, 723-32.
    • Kasim-Karakas, S.E., Cunningham, W.M., Tsodikov A. (2007). Relation of nutrients and hormones in polycystic ovary syndrome. American Journal of Clinical Nutrition, 85, 688-94.
    • Ledger, W.L., Clark, T. (2003). Long‚ąíterm consequences of polycystic ovary syndrome. Royal College of Obstetrician and Gynaecologists Physicians Guidelines. No.33.
    • Magnotti, M., Futterweit, W. (2007). Obesity and the Polycystic Ovary Syndrome. Medical Clinics of North America, 91,1151-68, ix-x.
    • Marks, V. (1987). Glycaemic stability in healthy subjects: fluctuations in blood glucose concentration during the day. In: Andreani, D., Marks, V., and Lefebvre, P.J. (Eds.), Hypoglycaemia (pp. 19-24). New York: Serona Symposia Publications from Raven Press.
    • Marsh, K.A., Steinbeck, K.S., Atkinson, F.S., Petocz, P., Brand-Miller, J.C. (2010). Effect of a low glycemic index compared with a conventional healthy diet on polycystic ovary syndrome. American Journal of Clinical Nutrition, 92, 83-92
    • Matthews, G., Jones, D.M., Chamberlain, G. A. (1990). Refining the measurement of mood: The UWIST Mood Adjective Checklist. British Journal of Clinical Psychology, 81, 17-42.
    • McCrimmon, R.J., Frier, B.M., Deary, I.J. (1999). Appraisal of mood and personality during hypoglycaemia in human subjects. Physiology & Behavior, 67, 27-33.
  • No related research data.
  • Discovered through pilot similarity algorithms. Send us your feedback.

Share - Bookmark

Download from

Cite this article