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Corona, Giulia; Vauzour, David; Hercelin, Justine; Williams, Claire M.; Spencer, Jeremy P. E. (2013)
Publisher: Mary Ann Leibert Inc
Languages: English
Types: Article
Subjects:
Aims: While much data exist for the effects of flavonoid-rich foods on spatial memory in rodents, there are no such data for foods/beverages predominantly containing hydroxycinnamates and phenolic acids. To address this, we investigated the effects of moderate Champagne wine intake, which is rich in these components, on spatial memory and related mechanisms relative to the alcohol- and energy-matched controls. Results: In contrast to the isocaloric and alcohol-matched controls, supplementation with Champagne wine (1.78 ml/kg BW, alcohol 12.5% vol.) for 6 weeks led to an improvement in spatial working memory in aged rodents. Targeted protein arrays indicated that these behavioral effects were paralleled by the differential expression of a number of hippocampal and cortical proteins (relative to the isocaloric control group), including those involved in signal transduction, neuroplasticity, apoptosis, and cell cycle regulation. Western immunoblotting confirmed the differential modulation of brain-derived neurotrophic factor, cAMP response-element-binding protein (CREB), p38, dystrophin, 2',3'-cyclic-nucleotide 3'-phosphodiesterase, mammalian target of rapamycin (mTOR), and Bcl-xL in response to Champagne supplementation compared to the control drink, and the modulation of mTOR, Bcl-xL, and CREB in response to alcohol supplementation. Innovation: Our data suggest that smaller phenolics such as gallic acid, protocatechuic acid, tyrosol, caftaric acid, and caffeic acid, in addition to flavonoids, are capable of exerting improvements in spatial memory via the modulation in hippocampal signaling and protein expression. Conclusion: Changes in spatial working memory induced by the Champagne supplementation are linked to the effects of absorbed phenolics on cytoskeletal proteins, neurotrophin expression, and the effects of alcohol on the regulation of apoptotic events in the hippocampus and cortex. Antioxid. Redox Signal. 00, 000-000.
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    • 1. Anderson JL, Head SI, Rae C, and Morley JW. Brain function in Duchenne muscular dystrophy. Brain 125: 4-13, 2002.
    • 2. Assuncao M, Santos-Marques MJ, de Freitas V, Carvalho F, Andrade JP, Lukoyanov NV, and Paula-Barbosa MM. Red wine antioxidants protect hippocampal neurons against ethanol-induced damage: a biochemical, morphological and behavioral study. Neuroscience 146: 1581-1592, 2007.
    • 3. Bramham CR and Messaoudi E. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 76: 99-125, 2005.
    • 4. Breitling R, Armengaud P, Amtmann A, and Herzyk P. Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett 573: 83-92, 2004.
    • 5. Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee HG, Smith MA, and Joseph JA. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci 7: 309-316, 2004.
    • 6. Chamkha M, Cathala B, Cheynier V, and Douillard R. Phenolic composition of champagnes from Chardonnay and Pinot Noir vintages. J Agric Food Chem 51: 3179-3184, 2003.
    • 7. Chan SL, Capdeville-Atkinson C, and Atkinson J. Red wine polyphenols improve endothelium-dependent dilation in rat cerebral arterioles. J Cardiovasc Pharmacol 51: 553-558, 2008.
    • 8. Chan SL, Tabellion A, Bagrel D, Perrin-Sarrado C, Capdeville-Atkinson C, and Atkinson J. Impact of chronic treatment with red wine polyphenols (RWP) on cerebral arterioles in the spontaneous hypertensive rat. J Cardiovasc Pharmacol 51: 304-310, 2008.
    • 9. Constant J. Alcohol, ischemic heart disease, and the French paradox. Coron Artery Dis 8: 645-649, 1997.
    • 10. Corder R. Red wine, chocolate and vascular health: developing the evidence base. Heart 94: 821-823, 2008.
    • 11. D'Angelo S, Manna C, Migliardi V, Mazzoni O, Morrica P, Capasso G, Pontoni G, Galletti P, and Zappia V. Pharmacokinetics and metabolism of hydroxytyrosol, a natural antioxidant from olive oil. Drug Metab Dispos 29: 1492-1498, 2001.
    • 12. Dal-Ros S, Bronner C, Auger C, and Schini-Kerth VB. Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middleaged rats: role of oxidative stress. Biochem Biophys Res Commun 419: 381-387, 2012.
    • 13. Freund G. Apoptosis and gene expression: perspectives on alcohol-induced brain damage. Alcohol 11: 385-387, 1994.
    • 14. Ghosh D and Scheepens A. Vascular action of polyphenols. Mol Nutr Food Res 53: 322-331, 2009.
    • 15. Glisky EL. Changes in Cognitive Function in Human Aging. In: Brain Aging: Models, Methods, and Mechanisms, edited by Riddle DR. Boca Raton (FL): CRC Press, 2007.
    • 16. Goda Y. Cadherins communicate structural plasticity of presynaptic and postsynaptic terminals. Neuron 35: 1-3, 2002.
    • 17. Hayakawa N, Kato H, and Araki T. Age-related changes of astorocytes, oligodendrocytes and microglia in the mouse hippocampal CA1 sector. Mech Ageing Dev 128: 311-316, 2007.
    • 18. Hutchison MR. BDNF Alters ERK/p38 MAPK Activity Ratios to Promote Differentiation in Growth Plate Chondrocytes. Mol Endocrinol 26: 1406-1416, 2012.
    • 19. Jensen LJ, Kuhn M, Stark M, Chaffron S, Creevey C, Muller J, Doerks T, Julien P, Roth A, Simonovic M, Bork P, and von Mering C. STRING 8-a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res 37: D412-D416, 2009.
    • 20. Joseph J, Cole G, Head E, and Ingram D. Nutrition, brain aging, and neurodegeneration. J Neurosci 29: 12795-12801, 2009.
    • 21. Joseph JA, Shukitt-Hale B, and Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr 81: 313S-316S, 2005.
    • 22. Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, and Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 19: 8114- 8121, 1999.
    • 23. Katoh-Semba R, Kaneko R, Kitajima S, Tsuzuki M, Ichisaka S, Hata Y, Yamada H, Miyazaki N, Takahashi Y, and Kato K. Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus. Neuroscience 163: 352-361, 2009.
    • 24. Kitamura Y, Shimohama S, Kamoshima W, Ota T, Matsuoka Y, Nomura Y, Smith MA, Perry G, Whitehouse PJ, and Taniguchi T. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain Res 780: 260-269, 1998.
    • 25. Krenz M and Korthuis RJ. Moderate ethanol ingestion and cardiovascular protection: from epidemiologic associations to cellular mechanisms. J Mol Cell Cardiol 52: 93-104, 2012.
    • 26. Lamport DJ, Dye L, Wightman JD, and Lawton CL. The effects of flavonoid and other polyphenol consumption on cognitive performance: A systematic research review of human experimental and epidemiological studies. Nutr Aging 1: 5-25, 2012.
    • 27. Lemeshow S, Letenneur L, Dartigues JF, Lafont S, Orgogozo JM, and Commenges D. Illustration of analysis taking into account complex survey considerations: the association between wine consumption and dementia in the PAQUID study. Personnes Ages Quid. Am J Epidemiol 148: 298-306, 1998.
    • 28. Letenneur L. Risk of dementia and alcohol and wine consumption: a review of recent results. Biol Res 37: 189-193, 2004.
    • 29. Li Q and Ren J. Chronic alcohol consumption alters mammalian target of rapamycin (mTOR), reduces ribosomal p70s6 kinase and p4E-BP1 levels in mouse cerebral cortex. Exp Neurol 204: 840-844, 2007.
    • 30. Liu P, Kemper LJ, Wang J, Zahs KR, Ashe KH, and Pasinetti GM. Grape seed polyphenolic extract specifically decreases abeta*56 in the brains of Tg2576 mice. J Alzheimers Dis 26: 657-666, 2011.
    • 31. Lu Y, Christian K, and Lu B. BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem 89: 312-323, 2008.
    • 32. Manach C, Scalbert A, Morand C, Remesy C, and Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr 79: 727-747, 2004.
    • 33. Meiergerd SM and Schenk JO. Striatal transporter for dopamine: catechol structure-activity studies and susceptibility to chemical modification. J Neurochem 62: 998-1008, 1994.
    • 34. Monti B, Berteotti C, and Contestabile A. Dysregulation of memory-related proteins in the hippocampus of aged rats and their relation with cognitive impairment. Hippocampus 15: 1041-1049, 2005.
    • 35. Muntoni F, Mateddu A, and Serra G. Passive avoidance behaviour deficit in the mdx mouse. Neuromuscul Disord 1: 121-123, 1991.
    • 36. Olton DS. The radial arm maze as a tool in behavioral pharmacology. Physiol Behav 40: 793-797, 1987.
    • 37. Orgogozo JM, Dartigues JF, Lafont S, Letenneur L, Commenges D, Salamon R, Renaud S, and Breteler MB. Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Rev Neurol (Paris) 153: 185-192, 1997.
    • 38. Priel A, Tuszynski JA, and Woolf NJ. Neural cytoskeleton capabilities for learning and memory. J Biol Phys 36: 3-21, 2009.
    • 39. Rainey-Smith S, Schroetke LW, Bahia P, Fahmi A, Skilton R, Spencer JP, Rice-Evans C, Rattray M, and Williams RJ. Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation. Neurosci Lett 438: 29-33, 2008.
    • 40. Reagan-Shaw S, Nihal M, and Ahmad N. Dose translation from animal to human studies revisited. FASEB J 22: 659- 661, 2008.
    • 41. Rendeiro C, Spencer JP, Vauzour D, Butler LT, Ellis JA, and Williams CM. The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms. Genes Nutr 4: 251-270, 2009.
    • 42. Rendeiro C, Vauzour D, Kean RJ, Butler LT, Rattray M, Spencer JP, and Williams CM. Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Psychopharmacology (Berl) 223: 319-330, 2012.
    • 43. Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, Howe EA, Li J, Thiagarajan M, White JA, and Quackenbush J. TM4 microarray software suite. Methods Enzymol 411: 134- 193, 2006.
    • 44. Serra A, Rubio L, Borras X, Macia A, Romero MP, and Motilva MJ. Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake. Mol Nutr Food Res 56: 486-496.
    • 45. Shukitt-Hale B, Cheng V, and Joseph JA. Effects of blackberries on motor and cognitive function in aged rats. Nutr Neurosci 12: 135-140, 2009.
    • 46. Shukitt-Hale B, McEwen JJ, Szprengiel A, and Joseph JA. Effect of age on the radial arm water maze-a test of spatial learning and memory. Neurobiol Aging 25: 223-229, 2004.
    • 47. Smale G, Nichols NR, Brady DR, Finch CE, and Horton WE, Jr. Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol 133: 225-230, 1995.
    • 48. Spencer JP. The impact of fruit flavonoids on memory and cognition. Br J Nutr 104 Suppl 3: S40-S47, 2010.
    • 49. Spencer JP. The impact of flavonoids on memory: physiological and molecular considerations. Chem Soc Rev 38: 1152- 1161, 2009.
    • 50. Spencer JP. Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain. Proc Nutr Soc 69: 244-260, 2010.
    • 51. This reference has been deleted.
    • 52. Spencer JP, Vauzour D, and Rendeiro C. Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects. Arch Biochem Biophys 492: 1-9, 2009.
    • 53. Sun CY, Qi SS, Lou XF, Sun SH, Wang X, Dai KY, Hu SW, and Liu NB. Changes of learning, memory and levels of CaMKII, CaM mRNA, CREB mRNA in the hippocampus of chronic multiple-stressed rats. Chin Med J (Engl) 119: 140- 147, 2006.
    • 54. Swiech L, Perycz M, Malik A, and Jaworski J. Role of mTOR in physiology and pathology of the nervous system. Biochim Biophys Acta 1784: 116-132, 2008.
    • 55. Thouvarecq R, Protais P, Jouen F, and Caston J. Influence of cholinergic system on motor learning during aging in mice. Behav Brain Res 118: 209-218, 2001.
    • 56. Tsai SJ, Chao CY, and Yin MC. Preventive and therapeutic effects of caffeic acid against inflammatory injury in striatum of MPTP-treated mice. Eur J Pharmacol 670: 441-447, 2011.
    • 57. Vafeiadou K, Vauzour D, and Spencer JP. Neuroinflammation and its modulation by flavonoids. Endocr Metab Immune Disord Drug Targets 7: 211-224, 2007.
    • 58. Vaillend C, Billard JM, and Laroche S. Impaired long-term spatial and recognition memory and enhanced CA1 hippocampal LTP in the dystrophin-deficient Dmd(mdx) mouse. Neurobiol Dis 17: 10-20, 2004.
    • 59. Vaillend C and Ungerer A. Behavioral characterization of mdx3cv mice deficient in C-terminal dystrophins. Neuromuscul Disord 9: 296-304, 1999.
    • 60. Valls-Pedret C, Lamuela-Raventos RM, Medina-Remon A, Quintana M, Corella D, Pinto X, Martinez-Gonzalez MA, Estruch R, and Ros E. Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk. J Alzheimers Dis 29: 773-782, 2012.
    • 61. Vauzour D, Corona G, and Spencer JP. Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyldopamine induced neurotoxicity. Arch Biochem Biophys 501: 106-111, 2010.
    • 62. Vauzour D, Houseman EJ, George TW, Corona G, Garnotel R, Jackson KG, Sellier C, Gillery P, Kennedy OB, Lovegrove JA, and Spencer JP. Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers. Br J Nutr 103: 1168-1178, 2010.
    • 63. Vauzour D and Minihane AM. Neuroinflammation and the APOe genotype: implications for Alzheimer's disease and modulation by dietary flavonoids and n-3 polyunsaturated fatty acids. Nutr Aging 1: 41-53, 2012.
    • 64. Vauzour D, Ravaioli G, Vafeiadou K, Rodriguez-Mateos A, Angeloni C, and Spencer JP. Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. Arch Biochem Biophys 476: 145-151, 2008.
    • 65. Vauzour D, Vafeiadou K, Corona G, Pollard SE, Tzounis X, and Spencer JP. Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury. J Agric Food Chem 55: 2854-2860, 2007.
    • 66. Vlkolinsky R, Cairns N, Fountoulakis M, and Lubec G. Decreased brain levels of 2¢,3¢-cyclic nucleotide-3¢-phosphodiesterase in Down syndrome and Alzheimer's disease. Neurobiol Aging 22: 547-553, 2001.
    • 67. Wei X, Ma Z, Fontanilla CV, Zhao L, Xu ZC, Taggliabraci V, Johnstone BH, Dodel RC, Farlow MR, and Du Y. Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity. Neuroscience 155: 1098-1105, 2008.
    • 68. Wei X, Zhao L, Ma Z, Holtzman DM, Yan C, Dodel RC, Hampel H, Oertel W, Farlow MR, and Du Y. Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury. Brain 127: 2629-2635, 2004.
    • 69. Williams CM, El Mohsen MA, Vauzour D, Rendeiro C, Butler LT, Ellis JA, Whiteman M, and Spencer JP. Blueberryinduced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brainderived neurotrophic factor (BDNF) levels. Free Radic Biol Med 45: 295-305, 2008.
    • 70. Willis LM, Shukitt-Hale B, and Joseph JA. Modulation of cognition and behavior in aged animals: role for antioxidantand essential fatty acid-rich plant foods. Am J Clin Nutr 89: 1602S-1606S, 2009.
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