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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Lund, Torben; Delves, Peter J. (1998)
Publisher: Journals of Reproduction and Fertility
Languages: English
Types: Article
Subjects:
The heterodimeric glycoprotein hormone, human chorionic gonadotropin, has been extensively characterized in terms of its recognition by mouse monoclonal antibodies. A number of different approaches have led to the definition of several epitope clusters on the surface of the molecule. These include epitopes located solely on the alpha- or beta-chain, some of which are masked when the two chains associate to form the holo-hormone. Additional epitopes comprise amino acids contributed by both the chains. In contrast to the extensive knowledge regarding B cell epitopes, the characterization of T cell epitopes on hCG has only recently begun to be explored.
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