Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Lund, Torben; Delves, Peter J. (1998)
Publisher: Journals of Reproduction and Fertility
Languages: English
Types: Article
The heterodimeric glycoprotein hormone, human chorionic gonadotropin, has been extensively characterized in terms of its recognition by mouse monoclonal antibodies. A number of different approaches have led to the definition of several epitope clusters on the surface of the molecule. These include epitopes located solely on the alpha- or beta-chain, some of which are masked when the two chains associate to form the holo-hormone. Additional epitopes comprise amino acids contributed by both the chains. In contrast to the extensive knowledge regarding B cell epitopes, the characterization of T cell epitopes on hCG has only recently begun to be explored.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • Acevedo HF, Tong JY and Hartsock RJ (1995) Human chorionic gonadotropinb subunit gene expression in cultured human fetal and cancer cells of different types and origins Cancer 76 1467-1475
    • Berger P, Panmoung W, Khaschabi D, Mayregger B and Wick G (1988) Antigenic features of human follicle stimulating hormone delineated by monoclonal antibodies and construction of an immunoradiometric assay Endocrinology 123 2351-2359
    • Berger P, Klieber R, Panmoung W, Madersbacher S, Wolf H and Wick G (1990) Monoclonal antibodies against the free subunits of human chorionic gonadotrophin Journal of Endocrinology 125 301-309
    • Bidart JM, Ozturk M, Bellet DH, Jolivet M, Gras MH, Troalen F, Bohuon CJ and Wands J R (1985) Identification of epitopes associated with hCG and the b hCG carboxyl terminus by monoclonal antibodies produced against a synthetic peptide Journal of Immunology 134 457-464
    • Bottger V, Micheel B, Scharte G, Kaiser G, Wolf G and Schmechta H (1993) Monoclonal antibodies to human chorionic gonadotropin (hCG) and their use in two-site binding enzyme immunoassays Hybridoma 12 81-91
    • Cosowsky L, Rao SN, MacDonald GJ, Papkoff H, Campbell RK and Moyle WR (1995) The groove between the a - and b -subunits of hormones with lutropin (LH) activity appears to contact the LH receptor, and its conformation is changed during hormone binding Journal of Biological Chemistry 270 20 011-20 019
    • Delves PJ, Lund T and Roitt IM (1997) Can epitope-focused vaccines select advantageous immune responses? Molecular Medicine Today 3 55-60
    • Deshmukh US, Pal R, Talwar GP and Gupta SK (1993) Antibody response against epitopes on hCG mapped by monoclonal antibodies in women immunized with an anti-hCG vaccine and its implications for bioneutralization Journal of Reproductive Immunology 25 103-117
    • Dirnhofer S, Klieber R, Deleeuw R, Bidart JM, Merz WE, Wick G and Berger P (1993) Functional and immunological relevance of the COOHterminal extension of human chorionic gonadotropin-b - implications for the WHO birth-control vaccine FASEB Journal 7 1381-1385
    • Dirnhofer S, Lechner O, Madersbacher S, Klieber R, de Leeuw R, Wick G and Berger P (1994a) Free a subunit of human chorionic gonadotrophin: molecular basis of immunologically and biologically active domains Journal of Endocrinology 140 145-154
    • Dirnhofer S, Madersbacher S, Bidart JM, Tenkortenaar PBW, Spottl G, Mann K, Wick G and Berger P (1994b) The molecular basis for epitopes on the free b -subunit of human chorionic gonadotropin (hCG), its carboxyl-terminal peptide and the hCG-b core fragment Journal of Endocrinology 141 153-162
    • Furui K, Suganuma N, Tsukahara S, Asada Y, Kikkawa F, Tanaka M, Ozawa T and Tomoda Y (1994) Identification of two point mutations in the gene coding luteinizing hormone (LH) b -subunit, associated with immunologically anomalous LH variants Journal of Clinical and Endocrinological Metabolism 78 107-113
    • Geissler M, Wands G, Gesien A, de la Monte S, Bellet D and Wands JR (1997) Genetic immunization with free human chorionic gonadotropin b - subunit elicits cytotoxic T lymphocyte responses and protects against tumor formation in mice Laboratory Investigations 76 859-871
    • Hojo H and Ryan RJ (1985) Monoclonal antibodies against human folliclestimulating hormone Endocrinology 117 2428-2434
    • *Jackson AM, Klonisch T, Lapthorn AJ, Berger P, Isaacs NW, Delves PJ, Lund T and Roitt IM (1996) Identification and selective destruction of shared epitopes in human chorionic gonadotropin b subunit Journal of Reproductive Immunology 31 21-36
    • Jiang X, Dreano M, Buckler DR, Cheng S, Ythier A, Wu H, Hendrickson WA and el Tayar N (1995) Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormonereceptor interactions Structure 3 1341-1353
    • Jones W , Judd S , Ing RMY, Powell J, Stevens VC, Bradley J, Denholm EH, Mueller UW and Griffin PD (1988) Phase I clinical trials of a World Health Organization birth control vaccine Lancet i 1295-1298
    • Klonisch T, Delves PJ, Berger P, Panayotou G, Lapthorn AJ, Isaacs NW, Wick G, Lund T and Roitt IM (1996a) Relative location of epitopes involved in synergistic antibody binding using human chorionic gonadotropin as a model European Journal of Immunology 26 1897-1905
    • Klonisch T, Panayotou G, Edwards P, Jackson AM, Berger P, Delves PJ, Lund T and Roitt IM (1996b) Enhancement in antigen binding by a combination of synergy and antibody capture Immunology 89 165-171
    • Kofler R, Kalchschmid E, Berger P and Wick G (1981) Production and characterization of monoclonal antibodies against bovine luteinizing hormone Immunobiology 160 196-207
    • Kofler R, Berger P and Wick G (1982) Monoclonal antibodies against human chorionic gonadotropin (hCG): I. Production, specificity, and intramolecular binding sites American Journal of Reproductive Immunology 2 212-216
    • Krichevsky A, Armstrong EG, Schlatterer J, Birken S, O'Connor J, Bikel K, Silverberg S, Lustbader JW and Canfield RE (1988) Preparation and characterization of antibodies to the urinary fragment of the human chorionic gonadotropin b -subunit Endocrinology 123 584-593
    • *Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ and Isaacs NW (1994) Crystal structure of human chorionic gonadotropin Nature 369 455-461
    • *Moyle WR, Matzuk MM, Campbell RK, Cogliani E, Dean ED, Krichevsky A, Barnett RW and Boime I (1990) Localization of residues that confer antibody binding specificity using human chorionic gonadotropin/ luteinizing hormone b -subunit chimeras and mutants Journal of Biological Chemistry 265 8511-8518
    • Norman RJ, Poulton T, Gard T and Chard T (1985) Monoclonal antibodies to human chorionic gonadotropin: implications for antigenic mapping, immunoradiometric assays, and clinical applications Journal of Clinical and Endocrinological Metabolism 61 1031-1038
    • Pantel J, Remy JJ, Salesse R, Jolivet A and Bidart JM (1993) Unmasking of an immunoreactive site on the alpha subunit of human choriogonadotropin bound to the extracellular domain of its receptor Biochemical and Biophysical Research Communications 195 588-593
    • Rouas N, Christophe S, Housseau F, Bellet D, Guillet JG and Bidart JM (1993) Influence of protein quaternary structure on antigen processing Journal of Immunology 150 782-792
    • Schwartz S, Berger P and Wick G (1986) The antigenic surface of human chorionic gonadotropin as mapped by mouse monoclonal antibodies Endocrinology 118 189-197
    • Schwarz S, Krude H, Nelboeck E, Berger P, Merz WE and Wick G (1991) Relationship of orientation with affinity and activity of receptor-bound glycosylation variants of human chorionic gonadotropin (hCG), as visualized by monoclonal antibodies (MCA) Journal of Receptor Research 11 437-458
    • *Talwar GP, Singh O, Pal R, Chatterjee N, Sahai P, Dhall K, Kaur J, Das SK, Suri S, Buckshee K, Saraya I and Saxena BN (1994) A vaccine that prevents pregnancy in women Proceedings of the National Academy of Sciences USA 91 8532-8536
    • Triozzi PL, Stevens VC, Aldrich A, Powell J, Todd CW and Newman MJ (1997) Phase I trials of a novel nonionic block copolymer adjuvant, RRL 1005, with a synthetic b -human chorionic gonadotropin subunit immunogen administered in aqueous solution Clinical Cancer Research 3 2355-2362
    • Tulppala M, Alfthan H, Stenman UH and Ylikorkala O (1992) Absence of autoantibodies to human chorionic gonadotropin in women with a history of habitual abortion Fertility and Sterility 58 946-949
    • *Wu H, Lustbader JW, Liu Y, Canfield RE and Hendrickson WA (1994) Structure of human chorionic gonadotropin at 2.6 Å resolution from MAD analysis of the selenomethionyl protein Structure 2 545-558
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article