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Filippi, Roberto; Rasetti, Mario; Lenzi, Marco; Bright, Peter (2014)
Publisher: Oxford University Press
Journal: Oxford Medical Case Reports
Languages: English
Types: Article
Subjects: Case Reports, 1300
Recent case reports suggest a possible causal correlation between antecollis and pramipexole. Here, we report the case of a 62-year-old Italian man with a 2-year history of Parkinson's disease (PD) and cervical spondylosis for which he was treated with pramipexole. He developed severe neck rigidity immediately after an inguinal hernia operation but several months after introduction of pramipexole. He was initially treated with painkillers and physiotherapy with no significant improvement. His condition deteriorated presenting disproportionate rigidity between anterior and posterior neck muscles (antecollis) to the extent that normal activities were severely restricted. However, significant improvement occurred after the withdrawal of pramipexole. The patient undertook a second cycle of physiotherapy with remarkable results and returned to function normally in everyday life. This case report suggests that neurologists should be motivated to inform the scientific community about other possible cases in which an association between antecollis and pramipexole might operate in PD.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR, Zalutsky R. How common are the 'common' neurologic disorders? Neurology 2007;68:326-37.
    • 2. M o¨ller JC, Oertel WH, Ko¨ ster J, Pezzoli G, Provinciali L. Long term efficacy and safety of pramipexole in advanced Parkinson's disease: results from a European multicenter trial. Mov Disord 2005;20:602 - 10.
    • 3. Weiner WJ, Factor SA, Jankovic J, Hauser RA, Tetrud JW, Waters CH, et al. The long-term safety and efficacy of pramipexole in advanced Parkinson's disease. Parkinsonism Relat Disord 2001;7:115- 20.
    • 4. Kim HJ, Jeon BS, Kim HS, Han S-H. Reversible antecollis associated with pramipexole in a patient with Parkinson's disease. J Clin Neurosci 2012;19:903 - 4.
    • 5. Suzuki M, Hirai T, Ito Y, Sakamoto T, Oka H, Kurita A, et al. Pramipexole-induced antecollis in Parkinson's disease. J Neurol Sci 2008;264:195 - 7.
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  • Discovered through pilot similarity algorithms. Send us your feedback.

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