LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Zhao, Y; Yao, J; Wang, M (2016)
Publisher: IOP Publishing
Languages: English
Types: Article
Subjects:
On-line monitoring of crystal size in the crystallization process is crucial to many pharmaceutical and fine-chemical industrial applications. In this paper, a novel method is proposed for the on-line monitoring of the cooling crystallization process of L-glutamic acid (LGA) using electrical impedance spectroscopy (EIS). The EIS method can be used to monitor the growth of crystal particles relying on the presence of an electrical double layer on the charged particle surface and the polarization of double layer under the excitation of alternating electrical field. The electrical impedance spectra and crystal size were measured on-line simultaneously by an impedance analyzer and focused beam reflectance measurement (FBRM), respectively. The impedance spectra were analyzed using the equivalent circuit model and the equivalent circuit elements in the model can be obtained by fitting the experimental data. Two equivalent circuit elements, including capacitance (C 2) and resistance (R 2) from the dielectric polarization of the LGA solution and crystal particle/solution interface, are in relation with the crystal size. The mathematical relationship between the crystal size and the equivalent circuit elements can be obtained by a non-linear fitting method. The function can be used to predict the change of crystal size during the crystallization process.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • [1] Alatalo H, Hatakka H, Kohonen J, Reinikainen S and Louhi-kultanen M 2010 Process control and monitoring of reactive crystallization of L-glutamic acid AIChE Journal, 56, 2063-2067.
    • [2] Schorsch S, Vetter T and Mazzotti M 2012 Measuring multidimensional particle size distributions during crystallization Chem Eng Sci, 77, 130-142.
    • [3] Macdonald J R 1987 Impedance spectroscopy, emphasizing solid materials and systems A Wiley-Interscience publication.
    • [4] Bradshaw-Hajek B H, Miklavcic S J and White L R 2010 The actual dielectric response function for a colloidal suspension of spherical particles Langmuir, 26, 7875-7884.
    • [5] Grosse C and Delgado A V 2010 Dielectric dispersion in aqueous colloidal systems Curr. Opin. Colloid Interface Sci. 15, 145-159.
    • [6] Delgado A V, Arroyo F J, Gonzalez-Caballero F, Shilov V N and Borkovskaya Y B 1998 The effect of the concentration of dispersed particles on the mechanisms of low-frequency dielectric dispersion (lfdd) in colloidal suspensions 1998 Colloids Surf. A, 140, 139-149.
    • [7] Delacey E H B and White L R 1981 Dielectric response and conductivity of dilute suspensions of colloidal particles J. Chem. Soc., Faraday Trans, 77, 2007-2039.
    • [8] Arroyo F J, Carrique F, Bellini T and Delgado A V 1999 Dielectric dispersion of colloidal suspensions in the presence of stern layer conductance: Particle size effects J. Colloid Interface Sci. 210, 194-199.
    • [9] Carrique F, Arroyo F J and Delgado A V 1998 Effect of size polydispersity on the dielectric relaxation of colloidal suspensions: A numerical study in the frequency and time domains J. Colloid Interface Sci. 206, 569-576.
    • [10] Zhao Y and Wang M 2015 Experimental Study on Dielectric Relaxation of SiO2 Nano-particle Suspensions for Developing a Particle Characterization Method based on Electrical Impedance Spectroscopy Powder Technology 281, 200-213.
    • [11] Zhao Y, Wang M and Hammond R B 2013 Characterisation of Nano-particles: Relationship between Particle Size and Electrical Impedance Spectra J Nanosci Nanotechno 13(2), 808-812.
    • [12] Nahvi M and Hoyle B S 2008 Wideband electrical impedance tomography Meas. Sci. Technol. 19, 094011-1-9.
    • [13] Abbas A, Nobbs D and Romagnoli J 2002 A Investigation of on-line optical particle characterization in reaction and cooling crystallization systems. Current state of the art, Meas. Sci. Technol. 3, 349 356.
    • [14] Scholl J, Bonalumi D, Vicum L, Mazzotti M and Muller M 2006 In situ monitoring and modeling of the solvent-mediated polymorphic transformation of l-glutamic acid", Cryst. Growth Des. 6, 881-891.
    • [15] De Anda J C, Wang X Z, Lai X, Roberts K J, Jennings K H, Wilkinson M J, Watson D and Roberts D 2005 Real-time product morphology monitoring in crystallization using imaging technique", AIChE Journal, 51, 1406-1414.
    • [16] Zhao Y, Wang M and Hammond R B 2011 Characterisation of Crystallisation Processes with Electrical Impedance Spectroscopy Nucl. Eng. Des. 241, 1938-1944.
    • [17] Asami K 2011 Design of a measurement cell for low-frequency dielectric spectroscopy of biological cell suspensions Meas. Sci. Technol. 22(8) 85801-85807(7).
    • [18] Dukhin S S and Shilov V N 1980 Kinetic aspects of electrochemistry of disperse systems.2.Induced dipole-moment and the nonequilibrium double-layer of a colloid particle Adv. Colloid Interface Sci. 13, 153 195.
    • [19] O'Brien R W 1982 The response of a colloidal suspension to an alternating electric-field Adv. Colloid Interface Sci. 16, 281 320.
    • [20] Dudley L M, Bialkowski S, Or D and Junkermeier C 2003 Low frequency impedance behaviour of montmorillonite suspensions: Polarization mechanisms in the low frequency domain, Soil Sci. Soc. Am. J. 67, 518 526.
    • [21] Blewett J, McCarter W J, Chrisp T M, Starrs G 2001 Monitoring sedimentation of a clay slurry Géotechnique 51, No.8, 723-728.
    • [22] Franks W, Schenker I, Schmutz P and Hierlemann A 2005 Impedance characterization and modeling of electrodes for biomedical applications IEEE Trans. Biomed. Eng. 52 1295 302.
    • [23] Bechi M, Avendano C, Strigazzi A, Barbero G 2005 Impedance spectroscopy of water solutions: the role of ions at the liquid-electrode interface J. Phys. Chem. B 109, 23444-23449.
    • [24] Roldán-Toro R and Solier J D 2004 Wide-frequency-range dielectric response of polystyrene latex dispersions J. Colloid Interface Sci. 274, 76-88. [2125] Ben Ishai P, Talary M S and Caduff A 2013 Electrode polarization in dielectric measurements: a review Meas. Sci. Technol. 24, 102001-1-21. 35 30 25 20 15 Temperature (degree C)
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article