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Thomson, Neil C. (2016)
Publisher: Taylor and Francis
Languages: English
Types: Article

Classified by OpenAIRE into

mesheuropmc: hormones, hormone substitutes, and hormone antagonists
Corticosteroids are the most effective treatment for asthma, but the therapeutic response varies markedly between individuals, with up to one third of patients showing evidence of insensitivity to corticosteroids. This article summarizes information on genetic, environmental and asthma-related factors as well as demographic and pharmacokinetic variables associated with corticosteroid insensitivity in asthma. Molecular mechanisms proposed to explain corticosteroid insensitivity are reviewed including alterations in glucocorticoid receptor subtype, binding and nuclear translocation, increased proinflammatory transcription factors and defective histone acetylation. Current therapies and future interventions that may restore corticosteroid sensitivity in asthma are discussed, including small molecule drugs and biological agents. In the future, biomarkers may be used in the clinic to predict corticosteroid sensitivity in patients with poorly controlled asthma.
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    • 109. Spears M, Donnelly I, Jolly L et al. Effect of low-dose theophylline plus 116. Kobayashi Y, Wada H, Rossios C et al. A novel macrolide/fluoroketolide, 117. Essilfie A-T, Horvat JC, Kim RY et al. Macrolide therapy suppresses key features of 125. Khorasani N, Baker J, Johnson M, Chung KF, Bhavsar PK. Reversal of corticosteroid 127. Humbert M, De Blay F, Garcia G et al. Masitinib, a c-kit/PDGF receptor tyrosine kinase 141. Spears M, McSharry C, Thomson NC. Peroxisome proliferator-activated receptor142. Lea S, Plumb J, Metcalfe H et al. The effect of peroxisome proliferator-activated 164. Heaney LG, Djukanovic R, Woodcock A et al. Research in progress: Medical
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