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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Ettinger, U.; Mohr, C.; Gooding, D. C.; Cohen, A. S.; Rapp, A.; Haenschel, C.; Park, S. (2015)
Publisher: OXFORD UNIV PRESS
Languages: English
Types: Article
Subjects: Supplement Articles, RC0321, BF

Classified by OpenAIRE into

mesheuropmc: behavioral disciplines and activities
Schizotypy refers to a set of personality traits thought to reflect the subclinical expression of the signs and symptoms of schizophrenia. Here, we review the cognitive and brain functional profile associated with high questionnaire scores in schizotypy. We discuss empirical evidence from the domains of perception, attention, memory, imagery and representation, language, and motor control. Perceptual deficits occur early and across various modalities. While the neural mechanisms underlying visual impairments may be linked to magnocellular dysfunction, further effects may be seen downstream in higher cognitive functions. Cognitive deficits are observed in inhibitory control, selective and sustained attention, incidental learning, and memory. In concordance with the cognitive nature of many of the aberrations of schizotypy, higher levels of schizotypy are associated with enhanced vividness and better performance on tasks of mental rotation. Language deficits seem most pronounced in higher-level processes. Finally, higher levels of schizotypy are associated with reduced performance on oculomotor tasks, resembling the impairments seen in schizophrenia. Some of these deficits are accompanied by reduced brain activation, akin to the pattern of hypoactivations in schizophrenia spectrum individuals. We conclude that schizotypy is a construct with apparent phenomenological overlap with schizophrenia and stable interindividual differences that covary with performance on a wide range of perceptual, cognitive, and motor tasks known to be impaired in schizophrenia. The importance of these findings lies not only in providing a fine-grained neurocognitive characterization of a personality constellation known to be associated with real-life impairments, but also in generating hypotheses concerning the aetiology of schizophrenia.
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    • 1. Claridge G. Schizotypy: Implications for Illness and Health.Oxford: OUP; 1997.
    • 2. Raine A. Schizotypal personality: neurodevelopmental and psychosocial trajectories. Annu Rev Clin Psychol. 2006;2:291-326.
    • 3. Lenzenweger MF. Schizotypy and Schizophrenia: The View from Experimental Psychopathology. New York: Guilford Press; 2010.
    • 4. Gooding DC, Tallent KA, Matts CW. Clinical status of at-risk individuals 5 years later: further validation of the psychometric high-risk strategy. J Abnorm Psychol. 2005;114:170-175.
    • 5. Chapman LJ, Chapman JP, Kwapil TR, Eckblad M, Zinser MC. Putatively psychosis-prone subjects 10  years later. J Abnorm Psychol. 1994;103:171-183.
    • 6. David AS. Why we need more debate on whether psychotic 6.65 symptoms lie on a continuum with normality. Psychol Med. 2010;40:1935-1942.
    • 7. Nelson MT, Seal ML, Pantelis C, Phillips LJ. Evidence of a dimensional relationship between schizotypy and schizophrenia: a systematic review. Neurosci Biobehav Rev. 2013;37:317-327.
    • 8. Ettinger U, Meyhöfer I, Steffens M, Wagner M, Koutsouleris N. Genetics, cognition, and neurobiology of schizotypal personality: a review of the overlap with schizophrenia. Front Psychiatry. 2014;5:18.
    • 9. Fanous AH, Neale MC, Gardner CO, et al. Significant cor - relation in linkage signals from genome-wide scans of schizophrenia and schizotypy. Mol Psychiatry. 2007;12:958-965.
    • 10. Williams JH, Wellman NA, Allan LM, et al. Tobacco smoking correlates with schizotypal and borderline personality traits. Pers Indiv Differ. 1996;20:267-270.
    • 11. Williams JH, Wellman NA, Rawlins JN. Cannabis use 6.80 correlates with schizotypy in healthy people. Addiction. 1996;91:869-877.
    • 12. Barrantes-Vidal N, Lewandowski KE, Kwapil TR. Psychopathology, social adjustment and personality correlates of schizotypy clusters in a large nonclinical sample. Schizophr Res. 2010;122:219-225.
    • 13. Cohen AS, Davis TE III. Quality of life across the schizotypy spectrum: findings from a large nonclinical adult sample. Compr Psychiatry. 2009;50:408-414.
    • 14. Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull. 1991;17:555-564.
    • 15. Giakoumaki SG. Cognitive and prepulse inhibition deficits in psychometrically high schizotypal subjects in the general population: relevance to schizophrenia research. J Int Neuropsychol Soc. 2012;18:643-656.
    • 16. Mohr C, Ettinger U. An overview of the association between 6.95 schizotypy and dopamine. Front Psychiatry. 2014. AQ6
    • 17. Koychev I, El-Deredy W, Haenschel C, Deakin JF. Visual information processing deficits as biomarkers of vulnerability to schizophrenia: an event-related potential study in schizotypy. Neuropsychologia. 2010;48:2205-2214.
    • 18. Bedwell JS, Chan CC, Trachik BJ, Rassovsky Y. Changes in 6.100 the visual-evoked P1 potential as a function of schizotypy and background color in healthy young adults. J Psychiatr Res. 2013;47:542-547.
    • 19. Cappe C, Herzog MH, Herzig DA, Brand A, Mohr C. Cognitive disorganisation in schizotypy is associated with 6.105 deterioration in visual backward masking. Psychiatry Res. 2012;200:652-659.
    • 20. Richardson AJ, Gruzelier J. Visual processing, lateralization and syndromes of schizotypy. Int J Psychophysiol. 1994;18:227-239.
    • 21. Barbato M, Collinson SL, Casagrande M. Altered depth per- 6.110 ception is associated with presence of schizotypal personality traits. Cogn Neuropsychiatry. 2012;17:115-132.
    • 22. Uhlhaas PJ, Silverstein SM. Perceptual organization in schizophrenia spectrum disorders: empirical research and theoretical implications. Psychol Bull. 2005;131:618-632.
    • 23. Luh KE, Gooding DC. Perceptual biases in psychosis-prone individuals. J Abnorm Psychol. 1999;108:283-289.
    • 24. Uhlhaas PJ, Silverstein SM, Phillips WA, Lovell PG. Evidence for impaired visual context processing in schizotypy with thought disorder. Schizophr Res. 2004;68:249-260.
    • 25. Koychev I, Deakin JF, Haenschel C, El-Deredy W. Abnormal neural oscillations in schizotypy during a visual working memory task: support for a deficient top-down network? Neuropsychologia. 2011;49:2866-2873.
    • 26. Lagioia A, Van De Ville D, Debbané M, Lazeyras F, Eliez S. Adolescent resting state networks and their associations with schizotypal trait expression. Front Syst Neurosci. 2010;4.
    • 27. Mayer JS, Fukuda K, Vogel EK, Park S. Impaired contingent attentional capture predicts reduced working memory capacity in schizophrenia. PLoS One. 2012;7:e48586.
    • 28. Uhlhaas PJ, Phillips WA, Mitchell G, Silverstein SM. Perceptual grouping in disorganized schizophrenia. Psychiatry Res. 2006;145:105-117.
    • 29. Bates TC. The panmodal sensory imprecision hypothesis of schizophrenia: reduced auditory precision in schizotypy. Pers Indiv Differ. 2005;38:437-449.
    • 30. Croft RJ, Lee A, Bertolot J, Gruzelier JH. Associations of P50 suppression and desensitization with perceptual and cognitive features of “unreality” in schizotypy. Biol Psychiatry. 2001;50:441-446.
    • 31. Rabinowicz EF, Silipo G, Goldman R, Javitt DC. Auditory sensory dysfunction in schizophrenia: imprecision or distractibility? Arch Gen Psychiatry. 2000;57:1149-1155.
    • 32. Potter D, Summerfelt A, Gold J, Buchanan RW. Review of clinical correlates of P50 sensory gating abnormalities in patients with schizophrenia. Schizophr Bull. 2006;32:692-700.
    • 33. Klein C, Berg P, Rockstroh B, Andresen B. Topography of the auditory P300 in schizotypal personality. Biol Psychiatry. 1999;45:1612-1621.
    • 34. Nuchpongsai P, Arakaki H, Langman P, Ogura C. N2 and P3b components of the event-related potential in students at risk for psychosis. Psychiatry Res. 1999;88:131-141.
    • 35. Javitt DC. When doors of perception close: bottom-up models of disrupted cognition in schizophrenia. Annu Rev Clin Psychol. 2009;5:249-275.
    • 36. Park S, Schoppe S. Olfactory identification deficit in relation to schizotypy. Schizophr Res. 1997;26:191-197.
    • 37. Mohr C, Röhrenbach CM, Laska M, Brugger P. Unilateral olfactory perception and magical ideation. Schizophr Res. 2001;47:255-264.
    • 38. Mohr C, Hübener F, Laska M. Deviant olfactory experiences, magical ideation, and olfactory sensitivity: a study with healthy German and Japanese subjects. Psychiatry Res. 2002;111:21-33.
    • 39. Lenzenweger MF. Two-point discrimination thresholds and schizotypy: illuminating a somatosensory dysfunction. Schizophr Res. 2000;42:111-124.
    • 40. Chun CA, Minor KS, Cohen AS. Neurocognition in psychometrically defined college Schizotypy samples: we are not measuring the “right stuff ”. J Int Neuropsychol Soc. 2013;19:324-337.
    • 41. Gold JM, Fuller RL, Robinson BM, McMahon RP, Braun EL, Luck SJ. Intact attentional control of working memory encoding in schizophrenia. J Abnorm Psychol. 2006;115:658-673.
    • 42. Haenschel C, Linden D. Exploring intermediate phenotypes with EEG: working memory dysfunction in schizophrenia. Behav Brain Res. 2011;216:481-495.
    • 43. Bleuler E. Dementia Praecox or the Group of Schizophrenias. 7.60 New York: International Universities Press; 1950.
    • 44. Chen WJ, Hsiao CK, Lin CC. Schizotypy in community samples: the three-factor structure and correlation with sustained attention. J Abnorm Psychol. 1997;106:649-654.
    • 45. Lenzenweger MF, Cornblatt BA, Putnick M. Schizotypy and sustained attention. J Abnorm Psychol. 1991;100:84-89. 7.65
    • 46. Obiols JE, Garcia-Domingo M, de Trincheria I, Domenech E. Psychometric schizotypy and sustained attention in young males. Pers Indiv Differ. 1993;14:381-384.
    • 47. Gooding DC, Matts CW, Rollmann EA. Sustained attention deficits in relation to psychometrically identified schizotypy: evaluating a potential endophenotypic marker. Schizophr 7.70 Res. 2006;82:27-37.
    • 48. MacQueen GM, Galway T, Goldberg JO, Tipper SP. Impaired distractor inhibition in patients with schizophrenia on a negative priming task. Psychol Med. 2003;33:121-129.
    • 49. Park S, Lenzenweger MF, Püschel J, Holzman PS. Attentional 7.75 inhibition in schizophrenia and schizotypy: a spatial negative priming study. Cogn Neuropsychiatry. 1996;1:125-149.
    • 50. Minas RK, Park S. Attentional window in schizophrenia and schizotypal personality: insight from negative priming studies. Appl Prev Psychol. 2007;12:140-148.
    • 51. Chapman LJ, Chapman JP, Raulin ML. Body-image aberra- 7.80 tion in schizophrenia. J Abnorm Psychol. 1978;87:399-407.
    • 52. Peters ER, Pickering AD, Hemsley DR. 'Cognitive inhibition' and positive symptomatology in schizotypy. Br J Clin Psychol. 1994;33(pt 1):33-48.
    • 53. Launay G Slade P. The measurement of hallucinatory pre- 7.85 disposition in male and female prisoners. Pers Indiv Differ. 1981;2:221-234.
    • 54. Chapman LJ, Chapman JP, Raulin ML. Scales for physical and social anhedonia. J Abnorm Psychol. 1976;85:374-382.
    • 55. Eckblad M, Chapman LJ. Development and validation of a scale for hypomanic personality. J Abnorm Psychol. 7.90 1986;95:214-222.
    • 56. Kumari V, Ettinger U. In: Lubow RE, ed. Latent Inhibition. AQ8 Cambridge: Cambridge University Press; 2010:419-447.
    • 57. Gray NS, Fernandez M, Williams J, Ruddle RA, Snowden RJ. Which schizotypal dimensions abolish latent inhibition? Br J Clin Psychol. 2002;41:271-284. 7.95
    • 58. Gray NS, Snowden RJ, Peoples M, Hemsley DR, Gray JA. A demonstration of within-subjects latent inhibition in the human: limitations and advantages. Behav Brain Res. 2003;138:1-8.
    • 59. Kaplan O, Lubow RE. Ignoring irrelevant stimuli in latent 7.100 inhibition and Stroop paradigms: the effects of schizotypy and gender. Psychiatry Res. 2011;186:40-45.
    • 60. Evans LH, Gray NS, Snowden RJ. A new continuous withinparticipants latent inhibition task: examining associations with schizotypy dimensions, smoking status and gender. Biol Psychol. 2007;74:365-373. 7.105
    • 61. Forbes NF, Carrick LA, McIntosh AM, Lawrie SM. Working memory in schizophrenia: a meta-analysis. Psychol Med. 2009;39:889-905.
    • 62. Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry. 1992;49:975-982. 7.110
    • 63. Lee J, Park S. Working memory impairments in schizophrenia: a meta-analysis. J Abnorm Psychol. 2005;114:599-611.
    • 64. Park S, Holzman PS, Lenzenweger MF. Individual differences in spatial working memory in relation to schizotypy. J Abnorm Psychol. 1995;104:355-363.
    • 65. Tallent KA, Gooding DC. Working memory and Wisconsin Card Sorting Test performance in schizotypic individuals: a replication and extension. Psychiatry Res. 1999;89:161-170.
    • 66. Schmidt-Hansen M, Honey RC. Working memory and multidimensional schizotypy: dissociable influences of the differ - ent dimensions. Cogn Neuropsychol. 2009;26:655-670.
    • 67. Park S, McTigue K. Working memory and the syndromes of schizotypal personality. Schizophr Res. 1997;26:213-220.
    • 68. Gooding DC, Tallent KA. Spatial, object, and affective working memory in social anhedonia: an exploratory study. Schizophr Res. 2003;63:247-260.
    • 69. Haenschel C, Bittner RA, Haertling F, et al. Contribution of impaired early-stage visual processing to working memory dysfunction in adolescents with schizophrenia: a study with event-related potentials and functional magnetic resonance imaging. Arch Gen Psychiatry. 2007;64:1229-1240.
    • 70. Jones SH, Gray JA, Hemsley DR. The Kamin blocking effect, incidental learning and schizotypy (a reanalysis). Pers Indiv Differ. 1991;13:57-60.
    • 71. Burch GSJ, Hemsley DR, Corr PJ, Gwyer P. The relationship between incidental learning and multi-dimensional schizotypy as measured by the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE). Pers Indiv Differ. 2006;40:394.
    • 72. Hoshi R, Scoales M, Mason O, Kamboj SK. Schizotypy and emotional memory. J Behav Ther Exp Psychiatry. 2011;42:504-510.
    • 73. LaPorte DJ, Kirkpatrick B, Thaker GK. Psychosis-proneness and verbal memory in a college student population. Schizophr Res. 1994;12:237-245.
    • 74. Gooding DC, Braun JG. Visuoconstructive performance, implicit hemispatial inattention, and schizotypy. Schizophr Res. 2004;68:261-269.
    • 75. Liouta E, Smith AD, Mohr C. Schizotypy and pseudoneglect: a critical update on theories of hemispheric asymmetries. Cogn Neuropsychiatry. 2008;13:112-134.
    • 76. Folley BS, Park S. Verbal creativity and schizotypal personality in relation to prefrontal hemispheric laterality: a behavioral and near-infrared optical imaging study. Schizophr Res. 2005;80:271-282.
    • 77. Rapp AM, Langohr K, Mutschler DE, Klingberg S, Wild B, Erb M. Isn't it ironic? Neural correlates of irony comprehension in schizophrenia. PLoS One. 2013;8:e74224.
    • 78. Kosslyn SM, Thompson WL, Ganis G. The Case for Mental Imagery. Oxford: Oxford University Press; 2006.
    • 79. Linden DE, Thornton K, Kuswanto CN, Johnston SJ, van de Ven V, Jackson MC. The brain's voices: comparing nonclinical auditory hallucinations and imagery. Cereb Cortex. 2011;21:330-337.
    • 80. Oertel V, Rotarska-Jagiela A, van de Ven V, et  al. Mental imagery vividness as a trait marker across the schizophrenia spectrum. Psychiatry Res. 2009;167:1-11.
    • 81. Beaman CP Williams TI. Individual differences in mental control predict involuntary musical imagery. Music Sci. 2013;17:398-409.
    • 82. Aleman A, Böcker KBE, De Haan E.H.F. Disposition towards hallucinations and subjective versus objective vividness of imagery in normal subjects. Pers Indiv Differ. 1999;27:707-714.
    • 83. van de Ven V, Merckelbach H. The role of schizotypy, mental imagery, and fantasy proneness in hallucinatory reports of undergraduate students. Pers Indiv Differ. 2003;35:889-896.
    • 84. Steinisch M, Sulpizio V, Iorio AA, et  al. A virtual environ- 8.60 ment for egocentric and allocentric mental transformations: a study on a nonclinical population of adults with distinct levels of schizotypy. Biomed Tech (Berl). 2011;56:291-299.
    • 85. Thakkar KN, Park S. Empathy, schizotypy, and visuospatial transformations. Cogn Neuropsychiatry. 2010;15:477-500.
    • 86. Mohr C, Blanke O, Brugger P. Perceptual aberrations 8.65 impair mental own-body transformations. Behav Neurosci. 2006;120:528-534.
    • 87. Langdon R, Coltheart M. Visual perspective-taking and schizotypy: evidence for a simulation-based account of mentalizing in normal adults. Cognition. 2001;82:1-26.
    • 88. Park S, Matthews N, Gibson C. Imitation, simulation, and 8.70 schizophrenia. Schizophr Bull. 2008;34:698-707.
    • 89. Mohr C, Rowe AC, Blanke O. The influence of sex and empathy on putting oneself in the shoes of others. Br J Psychol. 2010;101:277-291.
    • 90. Mohr C, Rowe AC, Kurokawa I, Dendy L, Theodoridou A. 8.75 Bodily perspective taking goes social: the role of personal, interpersonal, and intercultural factors. J Appl Soc Psychol. 2013;43:1369-1381.
    • 91. Cohen AS, Hong SL. Understanding constricted affect in schizotypy through computerized prosodic analysis. J Pers Disord. 2011;25:478-491. 8.80
    • 92. Dickey CC, Vu MA, Voglmaier MM, Niznikiewicz MA, McCarley RW, Panych LP. Prosodic abnormalities in schizotypal personality disorder. Schizophr Res. 2012;142:20-30.
    • 93. Dickey CC, Morocz IA, Minney D, et al. Factors in sensory processing of prosody in schizotypal personality disorder: an fMRI experiment. Schizophr Res. 2010;121:75-89. 8.85
    • 94. Gooding DC, Tallent KA, Hegyi JV. Cognitive slippage in schizotypic individuals. J Nerv Ment Dis. 2001;189:750-756.
    • 95. Coleman MJ, Levy DL, Lenzenweger MF, Holzman PS. Thought disorder, perceptual aberrations, and schizotypy. J Abnorm Psychol. 1996;105:469-473. 8.90
    • 96. Langdon R, Coltheart M. Recognition of metaphor and irony in young adults: the impact of schizotypal personality traits. Psychiatry Res. 2004;125:9-20.
    • 97. Jahshan CS, Sergi MJ. Theory of mind, neurocognition, and functional status in schizotypy. Schizophr Res. 2007;89:278-286. 8.95
    • 98. Morrison SC, Brown LA, Cohen AS. A multidimensional assessment of social cognition in psychometrically defined schizotypy. Psychiatry Res. 2013;210:1014-1019.
    • 99. Rapp AM, Langohr K, Mutschler DE, Wild B. Irony and prov“erdbislickoem” prireohneincsiorenmianrkssc?hiSzocphihzroepnhira: Rdeos fTemreaalte. 8.100 patients 2014;2014:841086.
    • 100. Nunn J, Peters E. Schizotypy and patterns of lateral asymmetry on hemisphere-specific language tasks. Psychiatry Res. 2001;103:179-192.
    • 101. Humphrey MK, Bryson FM, Grimshaw GM. Metaphor pro- 8.105 cessing in high and low schizotypal individuals. Psychiatry Res. 2010;178:290-294.
    • 102. Rapp AM, Mutschler DE, Wild B, et  al. Neural correlates of irony comprehension: the role of schizotypal personality traits. Brain Lang. 2010;113:1-12.
    • 103. Kiang M. Schizotypy and language: a review. J Neurolinguist. 8.110 2010;23:193-203.
    • 104. Manschreck TC, Merrill AM, Jabbar G, Chun J, Delisi LE. Frequency of normative word associations in the speech of individuals at familial high-risk for schizophrenia. Schizophr Res. 2012;140:99-103.
    • 105. Kostova M, Bohec AL, Blanchet A. Event-related brain potential study of expectancy and semantic matching in schizotypy. Int J Psychophysiol. 2014;92:67-73.
    • 106. Mohr C, Landis T, Brugger P. Lateralized semantic priming: modulation by levodopa, semantic distance, and participants' magical beliefs. Neuropsychiatr Dis Treat. 2006;2:71-84.
    • 107. Nelson B, Whitford TJ, Lavoie S, Sass LA. What are the neurocognitive correlates of basic self-disturbance in schizophrenia? Integrating phenomenology and neurocognition: part 2 (aberrant salience). Schizophr Res. 2014;152:20-27.
    • 108. Nelson B, Whitford TJ, Lavoie S, Sass LA. What are the neurocognitive correlates of basic self-disturbance in schizophrenia?: integrating phenomenology and neurocognition. Part 1 (Source monitoring deficits). Schizophr Res. 2014;152:12-19.
    • 109. Siever LJ, Davis KL. The pathophysiology of schizophrenia disorders: perspectives from the spectrum. Am J Psychiatry. 2004;161:398-413.
    • 110. Schofield K, Mohr C. Schizotypy and hemispheric asymmetry: results from two Chapman scales, the O-LIFE questionnaire, and two laterality measures. Laterality. 2014;19:178-200.
    • 111. Mohr C, Krummenacher P, Landis T, Sandor PS, Fathi M, Brugger P. Psychometric schizotypy modulates levodopa effects on lateralized lexical decision performance. J Psychiatr Res. 2005;39:241-250.
    • 112. Chan RC, Gottesman II. Neurological soft signs as candidate endophenotypes for schizophrenia: a shooting star or a Northern star? Neurosci Biobehav Rev. 2008;32:957-971.
    • 113. Obiols JE, Serrano F, Caparrós B, Subirá S, Barrantes N. Neurological soft signs in adolescents with poor performance on the continous performance test: markers of liability for schizophrenia spectrum disorders? Psychiatry Res. 1999;86:217-228.
    • 114. Barkus E, Stirling J, Hopkins R, Lewis S. The presence of neurological soft signs along the psychosis proneness continuum. Schizophr Bull. 2006;32:573-577.
    • 115. Mohr C, Landis T, Sandor PS, Fathi M, Brugger P. Nonstereotyped responding in positive schizotypy after a single dose of levodopa. Neuropsychopharmacology. 2004;29:1741-1751.
    • 116. Lenzenweger MF, Maher BA. Psychometric schizotypy and motor performance. J Abnorm Psychol. 2002;111:546-555.
    • 117. Zhao Q, Li Z, Huang J, et al. Neurological soft signs are not “soft” in brain structure and functional networks: evidence from ALE meta-analysis. Schizophr Bull. 2014;40:626-641.
    • 118. Thakkar KN, Peterman JS, Park S. Altered brain activation during action imitation and observation in schizophrenia: a translational approach to investigating social dysfunction in schizophrenia. Am J Psychiatry. 2014;171:539-548.
    • 119. Levy DL, Sereno AB, Gooding DC, O'Driscoll GA. Eye tracking dysfunction in schizophrenia: characterization and pathophysiology. Curr Top Behav Neurosci. 2010;4:311-347.
    • 120. Gooding DC, Basso MA. The tell-tale tasks: a review of saccadic research in psychiatric patient populations. Brain Cogn. 2008;68:371-390.
    • 121. Kendler KS, Ochs AL, Gorman AM, Hewitt JK, Ross DE, Mirsky AF. The structure of schizotypy: a pilot multitrait twin study. Psychiatry Res. 1991;36:19-36.
    • 122. Gooding DC, Miller MD, Kwapil TR. Smooth pursuit eye tracking and visual fixation in psychosis-prone individuals. Psychiatry Res. 2000;93:41-54.
    • 123. Holahan AL, O'Driscoll GA. Antisaccade and smooth pursuit performance in positive- and negative-symptom schizotypy. Schizophr Res. 2005;76:43-54.
    • 124. O'Driscoll GA, Lenzenweger MF, Holzman PS. Antisaccades 9.60 and smooth pursuit eye tracking and schizotypy. Arch Gen Psychiatry. 1998;55:837-843.
    • 125. Ettinger U, Kumari V, Crawford TJ, et al. Saccadic eye movements, schizotypy, and the role of neuroticism. Biol Psychol. 2005;68:61-78.
    • 126. Gooding DC. Antisaccade task performance in question- 9.65 naire-identified schizotypes. Schizophr Res. 1999;35:157-166.
    • 127. Kattoulas E, Evdokimidis I, Stefanis NC, Avramopoulos D, Stefanis CN, Smyrnis N. Predictive smooth eye pursuit in a population of young men: II. Effects of schizotypy, anxiety and depression. Exp Brain Res. 2011;215:219-226.
    • 128. Thaker GK, Ross DE, Buchanan RW, Adami HM, Medoff 9.70 DR. Smooth pursuit eye movements to extra-retinal motion signals: deficits in patients with schizophrenia. Psychiatry Res. 1999;88:209-219.
    • 129. Meyhofer I, Steffens M, Kasparbauer A, Grant P, Weber B, Ettinger U. Neural mechanisms of smooth pursuit eye move- 9.75 ments in schizotypy. Hum Brain Mapp. 2014.
    • 130. Mason O, Linney Y, Claridge G. Short scales for measuring schizotypy. Schizophr Res. 2005;78:293-296.
    • 131. Lencer R, Nagel M, Sprenger A, Heide W, Binkofski F. Reduced neuronal activity in the V5 complex underlies smooth-pursuit deficit in schizophrenia: evidence from an 9.80 fMRI study. Neuroimage. 2005;24:1256-1259.
    • 132. Gooding DC, Shea HB, Matts CW. Saccadic performance in questionnaire-identified schizotypes over time. Psychiatry Res. 2005;133:173-186.
    • 133. Rust J. The Rust Inventory of Schizotypal Cognitions (RISC). Schizophr Bull. 1988;14:317-322. 9.85
    • 134. Aichert DS, Williams SC, Möller HJ, Kumari V, Ettinger U. Functional neural correlates of psychometric schizotypy: an fMRI study of antisaccades. Psychophysiology. 2012;49:345-356.
    • 135. Raemaekers M, Jansma JM, Cahn W, et  al. Neuronal sub- 9.90 strate of the saccadic inhibition deficit in schizophrenia investigated with 3-dimensional event-related functional magnetic resonance imaging. Arch Gen Psychiatry. 2002;59:313-320.
    • 136. Raemaekers M, Ramsey NF, Vink M, van den Heuvel MP, Kahn RS. Brain activation during antisaccades in unaffected relatives of schizophrenic patients. Biol Psychiatry. 9.95 2006;59:530-535.
    • 137. Camchong J, Dyckman KA, Austin BP, Clementz BA, McDowell JE. Common neural circuitry supporting volitional saccades and its disruption in schizophrenia patients and relatives. Biol Psychiatry. 2008;64:1042-1050.
    • 138. Crawford TJ, Puri BK, Nijran KS, Jones B, Kennard C, 9.100 Lewis SW. Abnormal saccadic distractibility in patients with schizophrenia: a 99mTc-HMPAO SPET study. Psychol Med. 1996;26:265-277.
    • 139. McDowell JE, Brown GG, Paulus M, et al. Neural correlates of refixation saccades and antisaccades in normal and schizo- 9.105 phrenia subjects. Biol Psychiatry. 2002;51:216-223.
    • 140. Meyhöfer I, Steffens M, Kasparbauer A, Grant P, Weber B, Ettinger U. Neural mechanisms of smooth pursuit eye movements in schizotypy. Human Brain Mapp. 2014.
    • 141. Rawlings D, Williams B, Haslam N, Claridge G. Taxometric analysis supports a dimensional latent trait structure for schi- 9.110 zotypy. Pers Indiv Diff. 2008;44:1640-1651.
    • 142. Tsuang MT, Van Os J, Tandon R, et al. Attenuated psychosis 9.112 syndrome in DSM-5. Schizophr Res. 2013;150:31-35.
    • 143. Koychev I, Barkus E, Ettinger U, et al. Evaluation of state and trait biomarkers in healthy volunteers for the development of novel drug treatments in schizophrenia. J Psychopharmacol. 2011;25:1207-1225.
    • 144. Dourish CT, Dawson GR. Precompetitive consortium approach to validation of the next generation of biomarkers in schizophrenia. Biomark Med. 2014;8:5-8.
    • 145. Koychev I, McMullen K, Lees J, et  al. A validation of cognitive biomarkers for the early identification of cognitive enhancing agents in schizotypy: a three-center doubleblind placebo-controlled study. Eur Neuropsychopharmacol. 2012;22:469-481.
    • 146. Schmechtig A, Lees J, Grayson L, et  al. Effects of risperidone, amisulpride and nicotine on eye movement control and their modulation by schizotypy. Psychopharmacology (Berl). 2013;227:331-345. 10.60
    • 147. Geyer MA, Wilkinson LS, Humby T, Robbins TW. Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiatry. 1993;34:361-372.
    • 148. Choi JS, Park JY, Jung MH, et  al. Phase-specific brain change of spatial working memory processing in genetic 10.65 and ultra-high risk groups of schizophrenia. Schizophr Bull. 2012;38:1189-1199.
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