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Sapuan, Shari; Kortsalioudaki, Christina; Anthony, Mark; Chang, John; Embleton, Nicholas D; Geethanath, Ruppa M; Gray, Jim; Greenough, Anne; Lal, Mithilesh K; Luck, Suzanne; Pattnayak, Santosh; Reynolds, Peter; Russell, Allison B; Scorrer, Timothy; Turner, Mark; Heath, Paul T; Vergnano, Stefania (2017)
Publisher: Elsevier
Languages: English
Types: Article
Subjects: neonatal listeriosis, early-onset neonatal infection, Listeriosis, puerperal sepsis, empiric antimicrobials
SummaryObjective To define the clinical features and outcomes of neonatal listeriosis, and identify the maternal risk factors to seek scope for improvement. Methods Neonatal listeriosis was identified prospectively from a United Kingdom neonatal infection surveillance network (neonIN) between 2004 and 2014. The participating neonatal units completed a study-specific proforma. Results The incidence of neonatal listeriosis was 3.4 per 100,000 live births. Of the 21 cases identified, 19 were confirmed with a median gestational age of 33 weeks and a median birth weight of 1960g. The majority had clinical features (95%, 18/19), presented within the first 24 hours (95%, 18/19), and received penicillin empirically (94%, 18/19). The neonatal case-fatality rate was 21% (24% if probable cases were included). A proportion of mothers were investigated (60%, 12/18) and diagnosed with listeriosis (58%, 7/12); 32% (6/19) were treated with antibiotics but only 33% (6/12) included penicillin. Discussion Despite its rarity and the prompt and appropriate use of antibiotics neonatal listeriosis has a high case-fatality rate. There is room for improvement in the adherence to the national guidance in the choice of empiric antibiotics for puerperal sepsis, which would target listeriosis. Strategies should be in place to prevent pregnancy-associated listeriosis in higher risk population.
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