LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Harris, Paul A.; Lamb, Justin; Heaton, Brian; Wheatley, Denys N. (2002)
Languages: English
Types: Article
Subjects:
BACKGROUND: \ud The issue remains unresolved as to whether low frequency magnetic fields can affect cell behaviour, with the possibility that they may be in part responsible for the increased incidence of leukaemia in parts of the population exposed to them.\ud \ud METHODS: \ud \ud Combined treatment of HeLa cells with gamma-irradiation (1, 3 and 5 Grays) and extra low frequency magnetic fields of ~50 Hz was carried out under rigorously controlled conditions.\ud \ud RESULTS: \ud \ud Synchronised cells progressing from S-phase arrived at mitosis on average marginally ahead of irradiation controls not exposed to ELF. In no instance out of a total of twenty separate experiments did this "double-insult" further delay entry of cells into mitosis, as had been anticipated.\ud \ud CONCLUSION: \ud \ud This apparently "non-genotoxic" agent (ELF) appears to be capable of affecting cells that would normally arrest for longer in G2, suggesting a weakening of the stringency of the late cycle (G2) checkpoint.\ud
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Wertheimer N, Leeper E: Electrical wiring configurations and childhood cancer. Amer J Epidem 1979, 109:273-284
    • 2. Feychting M, Ahlbom A: Magnetic fields and cancer in children residing near Swedish high-voltage power lines. Amer J Epidemiol 1993, 138:467-481
    • 3. Verkasalo PK, Pukkula E, Hongisto MY, Valjas JE, Heikkila KV, Koskenvuo M: Risk of cancer in Finnish children living close to power lines. Brit Med J 1993, 307:895-899
    • 4. Linet MS, Hatch EE, Kleinerman RA, Robison LL, Kaune WT, Friedman DR, Severson RK, Haines CM, Hartsock CT, Niwa S, Wacholder S, Tarone RE: Residential exposure to magnetic fields and acute lymphoblastic leukemia in children. New Eng J Med 1997, 337:1-7
    • 5. Campion EW: Power lines, cancer, and fear. New Engl J Med 1997, 337:44-45
    • 6. Park RL: Currents of Fear. In "Voodoo science; the road from foolishness to fraud". Oxford University Press, Oxford 2000, 140-161
    • 7. Adair RK: Constraints on biological weak effects of weak ELF electromagnetic fields. Physical Rev 1991, 43:1039-1040
    • 8. Murphy JC, Kaden DA, Warren J, Sivak A: Power frequency electric and magnetic fields: a review of genetic toxicology. Mutat Res 1993, 296:221-240
    • 9. Lane DP: p53, guardian of the genome. Nature 1992, 358:15-16
    • 10. Williams GT: Programmed cell death: Apoptosis and oncogenesis. Cell 1991, 65:1097-1098
    • 11. Harrington EA, Fanidi A, Evan GI: Oncogenes and cell death. Curr Opin Genet Dev 1994, 4:129
    • 12. Murray A: Cell cycle checkpoints. Curr Opin Cell Biol 1994, 6:872- 876
    • 13. Elledge SJ: Cell cycle checkpoints: preventing an identity crisis. Science 1996, 274:1664-1672
    • 14. Hartwell LH: Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 1992, 71:543-546
    • 15. Weinert TA, Lydall D: Cell cycle checkpoints, genetic instability and cancer. Semin Cancer Biol 1993, 4:129-140
    • 16. Hollstein M, Rice K, Greenblatt MS, Soussi T, Fuchs R, Sorlie T, Hovig E, Smith-Sørensen B, Montesano R, Harris CC: Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res 1994, 22:3551-3555
    • 17. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS, Bradley A: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992, 356:215-221
    • 18. Harvey M, McArthur MJ, Montgomery CA, Butel JS, Bradley A, Donehower LA: Spontaneous and carcinogen induced tumorigenesis in p53-deficient mice. Nature Genet 1993, 5:225-229
    • 19. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991, 51:6304-6311
    • 20. Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB: Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 1992, 89:7491-7495
    • 21. Livingstone LR, White A, Spouse J, Livanos E, Jacks T, Tlsty TD: Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 1992, 70:923-935
    • 22. Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM: Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 1992, 70:937-948
    • 23. Harris PA: Biological effects of extremely low frequency magnetic fields. PhD Thesis ; University of Aberdeen. 1999
    • 24. Litovitz TA, Krause D, Mullins JM: Effect of coherence time of the the applied magnetic field on ornithine decarboxylase activity. Biochem Biophys Res Comm 1991, 178:862-865
    • 25. Hintenlang DE: Synergistic effects of ionising radiation and 60 Hz magnetic fields. Bioelectromagnetics 1993, 14:545-551
    • 26. Rosenthal M, Obe G: Effects of 50 Hz electromagnetic fields on proliferation and on chromosomal alterations in human peripheral lymphocytes untreated or pretreated with chemical mutagens. Mutat Res 1989, 210:329-335
    • 27. Lamb J, Wheatley DN: Cell killing by the novel imidazoacridinone antineoplastic agent, C-is inhibited at high concentrations coincident with dose-differentiated cell cycle perturbation. Br J Cancer 1311, 74:1359-1368
    • 28. Vindeløv LL, Christensen IJ, Nissen NI: A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 1983, 3:323-327
    • 29. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM: The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990, 63:1129- 1136
    • 30. Hwang E-S, Naeger LK, DiMaio D: Activation of the endogeneous p53 growth inhibitory pathway in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 gene. Oncogene 1996, 12:795-803
    • 31. Kimler BF, Schneiderman MH, Leeper DB: Induction of concentration-dependent blockade in the G2 phase of the cell cycle by cancer chemotherapeutic agents. Cancer Res 1978, 38:809-814
    • 32. Konopa J: G2 block induced by DNA crosslinking agents and its possible consequences. Biochem Pharmacol 1988, 37:2303-2309
    • 33. Lock RB, Ross WE: Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells. Cancer Res 1990, 50:3761-3766
    • 34. Sørenson CM, Eastman A: Mechanism of cis-diamminedichloroplatinum(II)-induced cytotoxicity: role of G2 arrest and DNA double-strand breaks. Cancer Res 1988, 48:4484-4488
    • 35. Gonzales AJ, Goldsworthy TL, Fox TR: The non-genotoxic chemical carcinogen phenobarbital delays G1 checkpoint response in B6C3F1 mouse hepatocytes. In: Keystone Symposium on 'Growth Control', Keystone CO, USA. 1997
    • 36. McCallum HM: Biological and health effects associated with some non-ionising radiations. PhD Thesis, University of Aberdeen. 1994
    • 37. Norbury C, Nurse P: Animal cell cycles and their control. Annu Rev Biochem 1992, 61:441-470
    • 38. Pines J, Hunter T: Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell 1989, 58:833-846
    • 39. Draetta G, Beach D: Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell 1988, 54:17-26
    • 40. Morgan DO: Principles of CDK regulation. Nature 1995, 374:131-134
    • 41. Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato JY: D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol 1994, 14:2066-2076
    • 42. Still M, Linström E, Ekstrand AJ, Mild KH, Mattsson M-O, Lundgren E: Inability of 50 Hz magnetic fields to regulate PKC and Ca2+- dependent gene expression in Jurkat cells. Cell Biol Internat 2002, 26:203-2098(doi:10.1006/cbir. 2001.0837)
    • 43. Linström E, Linström P, Berglund A, Mild KH, Lundgren E: Intracellular calcium oscillations induced in a T cell line by a weak 50 Hz magnetic field. J Cell Physiol 1993, 156:395-398
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article