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Russell, Alan; Chatterjee, Suman; Seed, Michael (2015)
Publisher: BMJ Publishing Group
Languages: English
Types: Article
Subjects: Article

Classified by OpenAIRE into

mesheuropmc: urologic and male genital diseases, female genital diseases and pregnancy complications
A patient with loin pain haematuria syndrome suffering chronic throbbing pulsing pain\ud overlaid with prolonged periods of incapacitating colic and overnight vomiting was\ud presented 10 months following diagnosis. Ultrasound was normal. No renal or ureteral\ud stones, or filling defects were seen on CT. At cytoscopy, bladder and urethra were normal,\ud and bloody urine effluxed from the left ureteric orifice. The ureters were normal at\ud diagnosis, and developed new abutting non‐penetrating calcifications by 8 months. Pain\ud episodes of complete incapacitating intensity of 2–4 h duration were reduced to 10 min\ud with 5 mg crushed tadalafil administered at onset. If tadalafil was delayed to after onset, the\ud original course of agony resulted. Daily tadalafil reduced loin pain intensity, but not the\ud exacerbations. Tadalafil efficacy may indicate that the pain exacerbations are due to spasm\ud of ureter smooth muscle. 5 mg tadalafil taken at onset alleviated severe loin pain\ud exacerbations in this case of loin pain haematuria syndrome.
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    • 1. Little  PJ,  Soper  JS,  de  Wardener  HE.  A  syndrome  of  loin  pain  and  haematuria  associated with disease of renal peripheral arteries. Q J Med 1967;36:253-9. 
    • 2. Taba  Taba  Vakili  S,  Alam  T,  Sollinger  H.  Loin  pain  hematuria  syndrome. Am  J  Kidney  Dis 2014;64:460-72. 
    • 3. Herbert  LA,  Bendetti  C,  Parikh  SV,  et  al.  Loin  Pain  Hematuria  syndrome.  Uptodate  2014. http://www.uptodate.com/contents/loin‐pain‐hematuria‐syndrome. 
    • 4. Spetie  DN,  Nadasdy  T,  Nadasdy  G,  et  al.  Proposed  pathogenesis  of  idiopathic  loin  pain‐hematuria syndrome. Am J Kidney Dis 2008;47:419-27. 
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