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Silverwood, RJ; De Stavola, BL; Cole, TJ; Leon, DA (2009)
Publisher: Nature Publishing Group
Languages: English
Types: Article

Classified by OpenAIRE into

mesheuropmc: nutritional and metabolic diseases
BACKGROUND: The development of obesity through childhood, often characterized by using body mass index (BMI), has received much recent interest because of the rapidly increasing levels of obesity worldwide. However, the extent to which the BMI trajectory in the first year of life (the BMI 'peak' in particular) is associated with BMI in later childhood has received little attention. SUBJECTS: The Uppsala Family Study includes 602 families, comprising mother, father and two consecutive singleton offspring, both of whom were delivered at the Uppsala Academic Hospital, Sweden, between 1987 and 1995. The children's postnatal growth data, including serial measurements of height and weight (from which BMI was calculated), were obtained from health records. All children had a physical examination when they were aged between 5 and 13 years, at which height and weight were again recorded and used to calculate age- and sex-adjusted BMI z-scores. METHODS: Subject-specific growth curves were fitted to the infant BMI data using penalized splines with random coefficients, and from these the location of the BMI peak for each participant was estimated. A multilevel modelling approach was used to assess the relationships between the BMI peak and BMI z-score in later childhood. RESULTS: The BMI peak occurred, on average, slightly later in female children, with a higher BMI peak in male children. Considered separately, both age and BMI at BMI peak were positively associated with later BMI z-score. Considered jointly, both dimensions of BMI peak retained their positive associations. CONCLUSIONS: The growth trajectory associated with higher childhood BMI appears to include a later and/or higher BMI peak in infancy.
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    • 1 World Health Organisation. Obesity: preventing and managing the global epidemic. World Health Organisation, Geneva, 2004.
    • 2 Serdula MK, Ivery D, Coates RJ, Freedman DS, Williamson DF, Byers T. Do obese children become obese adults? A review of the literature. Prev Med, 22: 167-77, 1993.
    • 3 Dietz WH. Health consequences of obesity in youth: childhood predictors of adult disease. Pediatrics, 101: 518-25, 1998.
    • 4 Parsons TJ, Power C, Logan S, Summerbell CD. Childhood predictors of adult obesity: a systematic review. Int J Obes, 23: S1-107, 1999.
    • 5 Rolland-Cachera MF, Deheeger M, Bellisle F, Sempe M, Guilloud-Bataille M, Patois E. Adiposity rebound in children: a simple indicator for predicting obesity. Am J Clin Nutr, 39: 129-35, 1984.
    • 6 Taylor RW, Grant AM, Goulding A, Williams, SM. Early adiposity rebound: review of papers linking this to subsequent obesity in children and adults. Curr Opin Clin Nutr Metab Care, 8: 607-12, 2005.
    • 7 Baird J, Fisher D, Lucas P, Kleijen J, Roberts H, Law C. Being big or growing fast: systematic review of size and growth in infancy and later obesity. Br Med J, 331: 929, 2005.
    • 8 Monteiro PO, Victora CG. Rapid growth in infancy and childhood and obesity in later life--a systematic review. Obes Rev, 6: 143-54, 2005.
    • 9 Ong KK, Loos RJ. Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr, 95: 904-8, 2006.
    • 10 Stettler N. Nature and strength of epidemiological evidence for origins of childhood and adulthood obesity in the first year of life. Int J Obes, 31: 1035-43, 2007. 18 Cole TJ, Freeman JV, Preece MA. Body mass index reference curves for the UK, 1990. Arch Dis Child, 73: 25-9, 1995.
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