Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Woods, DR; Mellor, A; Begley, J; Stacey, M; O'Hara, J; Hawkins, A; Yarker, J; Foxen, S; Smith, C; Boos, C (2013)
Languages: English
Types: Article
Our objective was to evaluate the utility of the natriuretic peptides BNP (brain natriuretic peptide) and NT-proBNP as markers of pulmonary artery systolic pressure (PASP) in trekkers ascending to high altitude (HA). 20 participants had BNP and NT-proBNP assayed and simultaneous echocardiographic assessment of PASP performed during a trek to 5150 m. PASP increased significantly (p=0.006) with ascent from 24+/-4 to 39+/-11 mm Hg at 5150 m. At 5150 m those with a PASP>/=40 mm Hg (n=8) (versus those with PASP<40 mm Hg) had higher post-exercise BNP (pg/ml): 54.5+/-36 vs. 13.4+/-17 (p=0.012). Their resting BNP at 5150 m was also higher: 57.3+/-43.4 vs. 12.6+/-13 (p=0.017). In those with a pathological (>/=400 pg/ml) rise in NT-proBNP at 5150 m (n=4) PASP was significantly higher: 45.9+/-7.5 vs. 32.2+/-6.2 mm Hg (p=0.015). BNP and NT-proBNP may reflect elevated PASP, a central feature of high altitude pulmonary oedema, at HA.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. BARTSCH P, MAIRBAURL H, MAGGIORINI M, SWENSON ER: Physiological aspects of high-altitude pulmonary edema. J Appl Physiol 98: 1101-1110, 2005.
    • 2. BERGER M, HESSE C, DEHNERT C, SIEDLER H, KLEINBONGARD P, BARDENHEUER HJ, KELM M, BÄRTSCH P, HAEFELI WE: Hypoxia Impairs Systemic Endothelial Function in Individuals Prone to High-Altitude Pulmonary Edema. Am J Respir Crit Care Med 172: 763-767, 2005.
    • 3. BERNSTEIN LH, ZIONS MY, ALAM ME, HAQ SA, HEITNER JF, ZARICH S, SEAMONDS B, BERGER S: What is the best approximation of reference normal forNTproBNP? Clinical levels for enhanced assessmentof NT-proBNP (CLEAN). J of Med Lab and Diag 2: 16-21, 2011.
    • 4. BLYTH KG, GROENNING BA, MARK PB, MARTIN TN, FOSTER JE, STEEDMAN T, MORTON JJ, DARGIE HJ, PEACOCK AJ: NT-proBNP can be used to detect right ventricular systolic dysfunction in pulmonary hypertension. Eur Respir J 29: 737-44. 2007
    • 5. BOOS CJ, HODKINSON P, MELLOR A, GREEN NP, WOODS DR: The Effects of Acute Hypobaric Hypoxia on Arterial Stiffness and Endothelial Function and its Relationship to Changes in Pulmonary Artery Pressure and Left Ventricular Diastolic Function. High Alt Med Biol 13: 105-111, 2012.
    • 6. CARGILL RI, LIPWORTH BJ: Acute effects of ANP and BNP on hypoxic pulmonary vasoconstriction in humans. Brit J of Clin Pharm 40: 585-590, 1995.
    • 7. CASALS G, ROS J, SIONIS A, DAVIDSON MM, MORALES-RUIZ M, JIMÉNEZ W: Hypoxia induces B-type natriuretic peptide release in cell lines derived from human cardiomyocytes. Am J Physiol Heart Circ Physiol 297: H550-H555, 2009.
    • 8. DE BOLD AJ. Determinants of brain natriuretic peptide gene expression and secretion in acute cardiac allograft rejection. Curr Opin Cardiol 22:146-50, 2007.
    • 9. DEHNERT C, GRÜNIG E, MERELES D, VON LENNEP N, BÄRTSCH P: Identification of individuals susceptible to high-altitude pulmonary oedema at low altitude. Eur Respir J 25: 545-551, 2005.
    • 10. DUE-ANDERSEN R, PEDERSEN-BJERGAARD U, HØI-HANSEN T, OLSEN NV, KISTORP C, FABER J, BOOMSMA F, THORSTEINSSON B: NT-pro-BNP during hypoglycemia and hypoxemia in normal subjects: impact of renin-angiotensin system activity. J Appl Physiol 104: 1080-1085, 2008.
    • 11. FEDDERSEN B, AUSSERER H, HADITSCH B, FRISCH H, NOACHTAR S, STRAUBE A: Brain natriuretic peptide at altitude: relationship to diuresis, natriuresis, and mountain sickness. Aviat Space Environ Med 80: 108-11, 2009.
    • 12. GOETZE JP, GORE A, MOLLER CH, STEINBRUCHEL DA, REHFELD JF, NIELSEN LB: Acute myocardial hypoxia increases BNP gene expression. FASEB J 18: 1928-30, 2004.
    • 13. GRUNIG E, MERELES D, HILDEBRANDT W, SWENSON ER, KUBLER W, KUECHERER H, BARTSCH P: Stress Doppler echocardiography for identification of susceptibility to high altitude pulmonary edema. J Am Coll Cardiol 35: 980-7, 2000.
    • 14. HALL C: NT-ProBNP: the mechanism behind the marker. J Card Fail 11: S81-3, 2005.
    • 15. HALL DP, DUNCAN K, BAILLIE JK: High altitude pulmonary oedema. J R Army Med Corps 157: 68-72, 2011.
    • 16. KERR AJ, RAFFEL OC, WHALLEY GA, ZENG I, STEWART RA: Elevated B-type natriuretic peptide despite normal left ventricular function on rest and exercise stress echocardiography in mitral regurgitation. Eur Heart J 29: 363-70, 2008.
  • No related research data.
  • No similar publications.

Share - Bookmark

Download from

Cite this article