LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
van Rooij, Frank J.A.; Qayyum, Rehan; Smith, Albert V.; Zhou, Yi; Trompet, Stella; Tanaka, Toshiko; Keller, Margaux F.; Chang, Li-Ching; Schmidt, Helena; Yang, Min-Lee; Chen, Ming-Huei; Hayes, James; Johnson, Andrew D.; Yanek, Lisa R.; Mueller, Christian; Lange, Leslie; Floyd, James S.; Ghanbari, Mohsen; Zonderman, Alan B.; Jukema, J. Wouter; Hofman, Albert; van Duijn, Cornelia M.; Desch, Karl C.; Saba, Yasaman; Ozel, Ayse B.; Snively, Beverly M.; Wu, Jer-Yuarn; Schmidt, Reinhold; Fornage, Myriam; Klein, Robert J. ... view all 100 authors View less authors (2016)
Publisher: Elsevier
Languages: English
Types: Article
Subjects: Article, R1
Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte traits in 71,638 individuals from European, East Asian, and African ancestries using a Bayesian approach to account for heterogeneity in allelic effects and variation in the structure of linkage disequilibrium between ethnicities. We identified seven loci for erythrocyte traits including a locus (RBPMS/GTF2E2) associated with mean corpuscular hemoglobin and mean corpuscular volume. Statistical fine-mapping at this locus pointed to RBPMS at this locus and excluded nearby GTF2E2. Using zebrafish morpholino to evaluate loss of function, we observed a strong in vivo erythropoietic effect for RBPMS but not for GTF2E2, supporting the statistical fine-mapping at this locus and demonstrating that RBPMS is a regulator of erythropoiesis. Our findings show the utility of trans-ethnic GWASs for discovery and characterization of genetic loci influencing hematologic traits.

Share - Bookmark

Funded by projects

  • NIH | CORONARY HEART DISEASE AND ...
  • NIH | CORONARY HEART DISEASE RISK...
  • NIH | STUDY CORONARY HEART DISEAS...
  • NIH | CORONARY HEART DISEASE AND ...
  • NIH | STUDY CORONARY HEART DISEAS...
  • EC | PHASE
  • NIH | GCRC-RENOVATION
  • WT | Understanding the genetic ba...
  • WT | Whole genome strategies for ...
  • WT | Statistical methods for the ...
  • NWO | NCHA Subsidiebesluit 2008-2012
  • NIH | Prospective meta-analyses o...
  • NIH | Genetic Modifiers of Beta-l...
  • NIH | Genetic Determinants of Vis...
  • NIH | HEALTH ABC--COORDINATING UN...
  • NIH | CHS-Transition Phase -26805...
  • NIH | Rare variants and NHLBI tra...
  • NIH | DYNAMICS OF HEALTH .AGING ....
  • NIH | CORONARY HEART DISEASE RISK...
  • NIH | Exceptional aging: 12 year ...
  • NIH | CARDIA-ECHOCARDIOGRAPHY REA...
  • NIH | CORONARY HEART DISEASE &STR...
  • NIH | UCLA Clinical and Translati...
  • NIH | Genome-Wide Association of ...
  • NIH | CARDIA-ECHOCARDIOGRAPHY REA...
  • NIH | MOLECULAR GENETIC STUDY OF ...
  • NIH | CORONARY HEART DISEASE &STR...
  • NIH | CENTRAL BLOOD ANALYSIS LABO...
  • NIH | AGES STUDY-THE REYKJAVIK ST...
  • NIH | CORONARY ARTERY DISEASE RIS...
  • NIH | Epidemiology of Venous Thro...
  • NIH | Healthy Aging In Nationally...
  • NIH | Nurse Model in Black Famili...
  • NIH | Institute for Clinical and ...
  • NIH | CHARGE consortium: gene di...
  • NIH | A Genome-Wide Association S...
  • NIH | Complex Trait Analysis of E...
  • NIH | Genome-Wide Association for...
  • NIH | DYNAMICS OF HEALTH, AGING, ...
  • NIH | CHS Events Follow-up Study
  • NIH | GWA for Gene-Environment In...
  • NIH | Linking disease-associated ...
  • NIH | THE FRAMINGHAM HEART STUDY-...
  • NIH | WGA Study to Identify Genet...
  • NIH | CORONARY ARTERY DISEASE RIS...
  • NIH | Genotypic Determinants of A...

Cite this article