LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
van Rooij, Frank J.A.; Qayyum, Rehan; Smith, Albert V.; Zhou, Yi; Trompet, Stella; Tanaka, Toshiko; Keller, Margaux F.; Chang, Li-Ching; Schmidt, Helena; Yang, Min-Lee; Chen, Ming-Huei; Hayes, James; Johnson, Andrew D.; Yanek, Lisa R.; Mueller, Christian; Lange, Leslie; Floyd, James S.; Ghanbari, Mohsen; Zonderman, Alan B.; Jukema, J. Wouter; Hofman, Albert; van Duijn, Cornelia M.; Desch, Karl C.; Saba, Yasaman; Ozel, Ayse B.; Snively, Beverly M.; Wu, Jer-Yuarn; Schmidt, Reinhold; Fornage, Myriam; Klein, Robert J. ... view all 100 authors View less authors (2017)
Publisher: Elsevier (Cell Press)
Languages: English
Types: Article
Subjects: Article, R1
Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte traits in 71,638 individuals from European, East Asian, and African ancestries using a Bayesian approach to account for heterogeneity in allelic effects and variation in the structure of linkage disequilibrium between ethnicities. We identified seven loci for erythrocyte traits including a locus (RBPMS/GTF2E2) associated with mean corpuscular hemoglobin and mean corpuscular volume. Statistical fine-mapping at this locus pointed to RBPMS at this locus and excluded nearby GTF2E2. Using zebrafish morpholino to evaluate loss of function, we observed a strong in?vivo erythropoietic effect for RBPMS but not for GTF2E2, supporting the statistical fine-mapping at this locus and demonstrating that RBPMS is a regulator of erythropoiesis. Our findings show the utility of trans-ethnic GWASs for discovery and characterization of genetic loci influencing hematologic traits.

Share - Bookmark

Funded by projects

  • NIH | Genetic Modifiers of Beta-l...
  • NIH | Prospective meta-analyses o...
  • NIH | STUDY CORONARY HEART DISEAS...
  • NIH | GCRC-RENOVATION
  • NIH | STUDY CORONARY HEART DISEAS...
  • NIH | CORONARY HEART DISEASE AND ...
  • EC | PHASE
  • NIH | CORONARY HEART DISEASE RISK...
  • NIH | CORONARY HEART DISEASE AND ...
  • NIH | Genetic Determinants of Vis...
  • NIH | Complex Trait Analysis of E...
  • NIH | A Genome-Wide Association S...
  • NWO | NCHA Subsidiebesluit 2008-2012
  • WT | Whole genome strategies for ...
  • WT | Understanding the genetic ba...
  • WT | Statistical methods for the ...
  • NIH | CHARGE consortium: gene di...
  • NIH | Institute for Clinical and ...
  • NIH | Nurse Model in Black Famili...
  • NIH | AGES STUDY-THE REYKJAVIK ST...
  • NIH | CARDIA-ECHOCARDIOGRAPHY REA...
  • NIH | MOLECULAR GENETIC STUDY OF ...
  • NIH | Healthy Aging In Nationally...
  • NIH | Epidemiology of Venous Thro...
  • NIH | CENTRAL BLOOD ANALYSIS LABO...
  • NIH | CORONARY HEART DISEASE &STR...
  • NIH | CORONARY ARTERY DISEASE RIS...
  • NIH | Rare variants and NHLBI tra...
  • NIH | HEALTH ABC--COORDINATING UN...
  • NIH | CHS-Transition Phase -26805...
  • NIH | DYNAMICS OF HEALTH .AGING ....
  • NIH | UCLA Clinical and Translati...
  • NIH | CORONARY HEART DISEASE RISK...
  • NIH | Exceptional aging: 12 year ...
  • NIH | CORONARY HEART DISEASE &STR...
  • NIH | CARDIA-ECHOCARDIOGRAPHY REA...
  • NIH | Genome-Wide Association of ...
  • NIH | DYNAMICS OF HEALTH, AGING, ...
  • NIH | Genome-Wide Association for...
  • NIH | CHS Events Follow-up Study
  • NIH | GWA for Gene-Environment In...
  • NIH | THE FRAMINGHAM HEART STUDY-...
  • NIH | Linking disease-associated ...
  • NIH | WGA Study to Identify Genet...
  • NIH | CORONARY ARTERY DISEASE RIS...
  • NIH | Genotypic Determinants of A...

Cite this article