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Pallen, Mark J. (2014)
Publisher: Cambridge University Press
Journal: Parasitology
Languages: English
Types: Article
Subjects: Special Issue Article, metagenomics, QH, diagnosis, high-throughput sequencing
SUMMARY The term ‘shotgun metagenomics’ is applied to the direct sequencing of DNA extracted from a sample without culture or target-specific amplification or capture. In diagnostic metagenomics, this approach is applied to clinical samples in the hope of detecting and characterizing pathogens. Here, I provide a conceptual overview, before reviewing several recent promising proof-of-principle applications of metagenomics in virus discovery, analysis of outbreaks and detection of pathogens in contemporary and historical samples. I also evaluate future prospects for diagnostic metagenomics in the light of relentless improvements in sequencing technologies.

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