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Dade-Robertson, Martyn; Corral, Javier Rodriguez; Mitrani, Helen; Zhang, Meng; Wipat, Anil; Ramirez-Figueroa, Carolina; Hernan, Luis (2016)
Publisher: ACADIA
Languages: English
Types: Unknown
Subjects: K100, C700, H200
The paper details the computational modelling work to define a new type of responsive material system based on genetically engineered bacteria cells. We introduce the discipline of synthetic biology and show how it may be possible to program a cell to respond genetically to inputs from its environment. We propose a system of synthetic biocementing, where engineered cells, living within a soil matrix, respond to pore pressure changes in their environment when the soil is loaded by synthesising new material and strengthening the soil. We develop a prototype CAD system which maps genetic responses of individual bacteria cells to geotechnical models of stress and pore pressure. We show different gene promoter sensitivities may make substantial changes to patterns of consolidation. We conclude by indicating future research in this area which combines both in vivo and in silico work.
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    • Atkinson, J. 1993. The Mechanics of Soils and Foundations. Maidenhead: McGraw-Hill.
    • Bossinesq, J. 1871. “Théorie de L'intumescence Liquide, Applelée Onde Solitaire Ou de Translation, Se Propageant Dans Un Canal Rectangulaire.” Comptes Rendus de l'Academie Des Sciences 72: 755-759.
    • Bredehoeft, J., and B. Hanshaw. 1968. “On the Maintenance of Anomalous Fluid Pressures. I Thick Sedimentary Sequences.” Geological Society of America Bulletin 79 (September): 1097-1106.
    • Newmark, Nathan. 1935. “Simplified Computation of Vertical Pressures in Elastic Foundations.” Engineering Experiment Station 33 (24).
    • Oxman, Neri, and Jesse Louis Rosenberg. 2007. “Material-Based Design Computation: An Inquiry into Digital Simulation of Physical Material Properties as Design Generators.” International Journal of Architectural Computing 5 (1) (January 1): 26-44. doi:10.1260/147807707780912985. http://multiscience.metapress.com/openurl.asp?genre=article&id=doi:10.1260/1478077077809 12985.
    • Powrie, W. 2014. Soil Mechanics: Concepts and Applications. London: CRC Press.
    • Strout, James Michael, and Tor Inge Tjelta. 2005. “In Situ Pore Pressures: What Is Their Significance and How Can They Be Reliably Measured?” Marine and Petroleum Geology 22 (1-2) (January): 275-285. doi:10.1016/j.marpetgeo.2004.10.024. http://linkinghub.elsevier.com/retrieve/pii/S0264817204001990.
    • Voigt, Christopher. 2012. “Synthetic Biology Scope, Applications and Implications.” London: Royal Academy of Engineering. doi:10.1021/sb300001c.
    • Welch, Timothy J, Anne Farewell, Frederick C Neidhardt, and Douglas H Bartlett. 1993. “Stress Response of Escherichia Coli to Elevated Hydrostatic Pressure.” Journal of Bacteriology 175 (22): 7170-7177.
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