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Razzak, R.A.; Bagust, J.; Docherty, Sharon; Hussein, W.; Hassan, Z.; Al-Kafaji, G.; Alotaibi, A.M. (2016)
Languages: English
Types: Article
Introduction: Diabetes-induced vestibular dysfunction has been commonly reported, and asymptomatic patients with type 2 diabetes display higher degrees of perceptual visual dependence for spatial orientation than healthy controls. This study aims to assess whether HbA1c can predict such visual dependence in the diabetic patients. Methods and Materials: Diabetic patients were divided into 2 groups: 22 subjects with “good” (HbA1c < 7%) and 25 with “poor” (HbA1c ≥\ud 7%) glycemic control. Otolithic vestibular function was tested using the computerized rod-and-frame test (CRFT) and results\ud for the two diabetic groups were compared to 29 healthy controls. Results: When the frame was tilted, the diabetic group with “good” glycemic control had largest positioning errors, with a significant difference only in comparison to the control group. The “good” glycemic group exhibited larger degree of asymmetry under titled frame condition. Although HbA1c was not associated with vestibular asymmetry in any diabetic group, it was significantly associated with visual dependence in the “good” glycemic group. During frame tilts, 10 diabetic patients had positioning errors above the reference range of 3.3°, 8 of which belonged to the “good” glycemic diabetic group. Conclusions: Diabetes disease processes may affect vestibular symmetry during visuo-vestibular conflicts, even in asymptomatic diabetics within the recommended glycemic range. The weak correlations between HbA1c and CRFT parameters may indicate that HbA1c cannot fully predict visual dependence or asymmetry on the CRFT in patients with diabetes, and different glycemic disorders may affect vestibular dependent spatial orientation in diabetic patients.
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    • Curthoys I S, Halmagyi G M. Vestibular compensation: a review of the oculomotor, neural, and clinical consequences of unilateral vestibular loss. J Vestib Res 1995, 5 (2): 67-107.
    • Brandt T, Strupp M, Arbusow V. Dieringer N. Plasticity of the vestibular system: central compensation and sensory substitution for vestibular deficits. Adv Neurol 1997, 73: 297-309.
    • Li J, Zhang T, Shen J, Gong J, Wang H, Zhang J, Pang Y. The changes in vestibular function in patients with diabetes mellitus and its clinical significance. J Clin Otorhinol, Head and Neck Surgery 2008, 22(1): 10 - 13.
    • Parkash M, Sumathi K. Evaluation of subclinical vestibular dysfunction in type II diabetes mellitus-correlating with HbA1c. Int J Pharma Bio Sci 2013, 4(4): 137 - 140.
    • Kamali B, Hajabolhassan, F, Fatahi, J, Esfahani, EN, Sarrafzadeh, J, Faghihzadeh, S. Effects of diabetes mellitus type I with or without neuropathy on vestibular evoked myogenic potentials. Acta Medica Iranica 2013, 5(12): 107 - 112.
    • Zelenka J et al. Disorders in blood supply of the inner ear as early symptom of diabetic angiopathy. J Laryngol Otol 1965, 79: 314 - 319.
    • Makishima K, Tanaka et al. Pathological changes of the inner ear and central auditory pathways in diabetics. Ann Otol Rhinol Laryngol 1971, 80: 218 - 228.
    • Nathan DM. The pathophysiology of diabetic complications: how much does the glucose hypothesis explain? Ann Intern Med 1996, 124: 86 - 89.
    • Acta Oto-Laryngol 1999, 119: 126 - 127.
    • [10] Murray KJ, Hill KD, Phillips B, Waterston J. The influence of otolith dysfunction on the clinical presentation of people with a peripheral vestibular disorder. American Physical Therapy Association 2: 143 sical., 2007.
    • [11] Akin FW, Murnane OD. Subjective visual vertical test. Semin Hear 2009, 30(4): 281 - 286.
    • [12] Vingerhoets RAA, De Vrijer M, Van Gisbergen JAM, Medendorp WP. Fusion of visual and vestibular tilt cues in the perception of visual vertical. J Neurophysiol 2009, 101: 1321 - 1333.
    • [13] Abdul Razzak R, Bagust J, Docherty S, Hussein W, AlOtaibi A. Augmented asymmetrical visual field dependence in asymptomatic diabetics: evidence of subclinical asymmetrical bilateral vestibular dysfunction. J Diabetes Complicat 2015, 29: 68 - 72.
    • [14] Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, et al. Association of glycemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000, 321(7258): 405- 412.
    • [15] Agrawal Y, Carey JP, Della Santina CC, Schubert MC, Minor L BY. Diabetes, vestibular dysfunction, and falls: analyses from the national health and nutrition examination survey. Otol Neurotol 2010, 31: 1445 - 1450.
    • [16] Docherty S, Bagust J. From line to dots: an improved computerized rod and frame system for testing subjective visual vertical and horizontal. BMC Res Notes 2010, 3(9): (www.biomedcentral.com/1756-0500/3/9).
    • [17] International Diabetes Federation (Clinical Guidelines Task Force) 2012. Global guidelines for type 2 diabetes: glucose control levels- recommendations. 43 - 47.
    • [18] Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, Peters AL, Tsapas A, Wender R. Matthews DR. Management of hyperglycemia in type 2 diabetes: a patient-centered approach position statement of the American diabetes association (ada) and the European association for the study of diabetes (EASD). Diabetes Care 2012, 35(6): 1364 - 1379.
    • [20] Van Dijk J-W, Manders RJF, Hartgens F, Stehouwer CD, Praet SFE, van Loon LJC. Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients. Diabetes Res Clin Pr 2011, 93: 31 - 37.
    • [21] Monnier L, Colette C. Owens DR. Glycemic variability: the third component of the dysglycemia in diabetes. Is it important? How to measure it? J Diabetes Sci Technol 2008, 2(6): 1094 - 1100.
    • [22] Ceriello A, Kilpatrick ES. Glycemic variability: both sides of the story. Diabetes Care 2013, 36: S272 - S275.
    • [23] Risso A, Mercuri F, Quagliaro L, Damante G, Ceriello A. Intermittent high glucose enhances apoptosis in human umbilical vein endothelial cells in culture. Am J Physiol Endocrinol Metab 2001, 281(5): E924 - E930.
    • [24] Quagliaro L, Piconi L, Assaloni R, Martinelli L, Motz E, Ceriello A. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes 2003, 52(11): 2795-2804.
    • [25] Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, Zuodar G, Ceriello A. Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 2005, 183(2): 259-267.
    • [26] Piconi L, Quagliaro L, Assaloni R, Da Ros R, Maier A, Zuodar G, Ceriello A. Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction. Diabetes Metab Res Rev 2006, 22(3): 198 - 203.
    • [27] Esparza CM, Jáuregui-Renaud K, Morelos CM, Muhl GE, Mendez MN, Carillo NS, Bello NS, Cardenas M. Systemic high blood pressure and inner ear dysfunction: a preliminary study. Clin Otolaryngol 2007, 32(3): 173 - 178.
    • [19] Campos C. Chronic hyperglycemia and Glucose toxicity: pathology and clinical sequelae. Postgrad Med 2012, 124(6): 90 - 97.
    • [28] Isableu B, Ohlmann T, Cremieux J, Amblard B. Selection of spatial frame of reference and postural control variability. Exp. Brain Res 1998, 114: 584 - 589.
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