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Tawfeek, HM; Saleem, IY; Roberts, M
Languages: English
Types: Article
Subjects: RS
The aim was to enhance the dissolution of lornoxicam (LOR) and to produce mini-tablets with an optimised system to provide a rapid-release multi-particulate formulation. LOR systems were prepared through co-evaporation with either polyethylene glycol 6000 or Pluronic® F-68 (PLU) and adsorption onto Neusilin® US2 alone or co-adsorption in the presence of different amounts of polysorbate 80. All systems were characterised by FT-IR, differential scanning calorimetry, X-ray diffraction, flowability and dissolution techniques. Mini-tablets were prepared using the system with the optimum dissolution profile and flowability. Tensile strengths, content uniformity and dissolution profiles of the mini-tablets were evaluated. The effects of different excipients and storage conditions on mini-tablet properties were also studied. The optimised rapid-release LOR mini-tablets were further evaluated for their in vivo pharmacokinetic profile. The co-evaporate of LOR with PLU showed significantly faster dissolution and superior flowability and was evaluated together with three directly compressible excipients (Cellactose® 80, StarLac® (STA) and Emcompress®) for mini-tablet formulation. The formulation with STA provided the optimum results in terms of tensile strength content uniformity and rapid drug release following a 3-month stability study and was selected for further in vivo evaluation. The pharmacokinetic profile indicated the potential of the mini-tablets achieving rapid release and increased absorption of LOR
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    • 1. Homdrum, E. M., Likar, R., Nell, G. (2006). "Xefo® Rapid: A novel effective tool for pain treatment." European Surgery 38(5): 342-352.
    • 2. Schroeder, S., Heuser, A., Tellmann, A., Goebel, K.J., Woehrmann, T. (2012) Local tolerance of intraarticular administration of lornoxicam into the rabbit knee joint. Rheumatology International 32(9): 2661-2667.
    • 3. Kidd, B., Frenzel, W. (1996) A multicenter, randomized, double blind study comparing lornoxicam with diclofenac in osteoarthritis." Journal of Rheumatology 23(9): 1605-1611
    • 4. Staunstrup, H., Ovesen, J., Larsen, U. T., Elbaek K., Larsen, U., Krøner, K. (1999). Efficacy and Tolerability of Lornoxicam versus Tramadol in Postoperative Pain. The Journal of Clinical Pharmacology 39(8): 834-841.
    • 5. Skjodt, N. M., Davies, N. M. (1998) Clinical Pharmacokinetics of Lornoxicam. Clinical Pharmacokinetics 34 (6) 421-428
    • 6. Gupta, M. K., Vanwert, A., Bogner, R. H. (2003) Formation of physically stable amorphous drugs by milling with NEU. Journal of Pharmaceutical Sciences 92(3): 536-551.
    • 7. Loftsson, T., Hreinsdóttir, D., Másson, M. (2005) Evaluation of cyclodextrin solubilization of drugs. International Journal of Pharmaceutics 302(1-2): 18-28
    • 8. Abou-Taleb, A. E., Abdel-Rhman. A. A., Samy, E. M.,Tawfeek, H. M. (2006). "Interaction of Rofecoxib with ß-cyclodextrin and Hydroxypropyl ß-cyclodextrin in solution and in solid state " Bulletin of Pharmaceutical Scienece of Assiut University 29(2): 236-252
    • 9. Badr-Eldin, S. M., Elkheshen, S. A., Ghorab, M. M. (2008). "Inclusion complexes of tadalafil with natural and chemically modified β-cyclodextrins. I: Preparation and in-vitro evaluation." European Journal of Pharmaceutics and Biopharmaceutics 70(3): 819-827
    • 10. Cheng, Y.Y., Yang, J.P. (2006) Solubilization of non-steroidal anti-inflammatory drugs in the presence of tween series surfactants. Physics and Chemistry of Liquids 44(3): 249-256
    • 11. Seedher, N., Kanojia, M. (2008). Micellar Solubilization of Some Poorly Soluble Antidiabetic Drugs: A Technical Note." AAPS PharmSciTech 9(2): 431-436.
    • 12. Chauhan, B., Shimpi, S., Paradkar, A. (2005) Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique. AAPS PharmSciTech 6(3): E405-E409.
    • 13. El-Badry, M., Fetih, G., Fathy, M. (2009) Improvement of solubility and dissolution rate of indomethacin by solid dispersions in Gelucire 50/13 and PEG4000. Saudi Pharmaceutical Journal 17(3): 217-225
    • 14. Wu, K., Li, J., Wang, W.N., Winstead, D. A. (2009) Formation and characterization of solid dispersions of piroxicam and polyvinylpyrrolidone using spray drying and precipitation with compressed antisolvent. Journal of Pharmaceutical Sciences 98(7): 2422-2431.
    • 15. Gupta, M. K., Goldman, D., Bogner, R. H., Tseng, Y.C. (2001) Enhanced Drug Dissolution and Bulk Properties of Solid Dispersions Granulated with a Surface Adsorbent. Pharmaceutical Development and Technology 6(4): 563-572.
    • 16. Takeuchi, H., Nagira, S., Tanimura, S., Yamamoto, H., Kawashima, Y. (2005) Tabletting of Solid Dispersion Particles Consisting of Indomethacin and Porous Silica Particles. Chemical and Pharmaceutical Bulletin 53(5): 487-491.
    • 17. Wang, L., De Cui, F., Sunada, H. (2006). Preparation and Evaluation of Solid Dispersions of Nitrendipine Prepared with Fine Silica Particles Using the Melt-Mixing Method. Chemical and Pharmaceutical Bulletin 54(1): 37-43.
    • 18. Vadher, A. H., Parikh, J.R., Parikh, R. H., Solanki, A. B. (2009) Preparation and Characterization of Co-Grinded Mixtures of Aceclofenac and NEU US2 for Dissolution Enhancement of Aceclofenac. AAPS PharmSciTech 10(2): 606-614.
    • 19. World Health Organization (2012) Development of paediatric medicines - Points to consider in pharmaceutical development.
    • 20. Lennartz P., Mielck. J.B. (1998). "Minitabletting: improving the compactability of paracetamol powder mixtures." International Journal of Pharmaceutics 173: 75-85
    • 21. Mohamed, F. A. A., Roberts, M., Seton, L., Ford, J. L., Levina, M., Rajabi-Siahboomi, A. R. (2013) The influence of HPMC concentration on release of theophylline or hydrocortisone from extended release mini-tablets. Drug Development and Industrial Pharmacy 39(8): 1167-1174.
    • 22. Dierickx, L., Saerens, L., Almeida A., De Beer, T., Remon, J.P., Vervaet, C. (2012). Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices. European Journal of Pharmaceutics and Biopharmaceutics 81 683-689
    • 23. Lingam, M., Ashok, T., Venkateswarlu, V., Rao, Y.M. (2008) Design and evaluation of a novel matrix type multiple units as biphasic gastroretentive drug delivery systems. AAPS PharmSciTech 9 1253-1261.
    • 24. Fell, J., Newton, JM. (1968). "The tensile strength of lactose tablets." Journal of Pharmacy and Pharmacology 20(8): 657-659
    • 25. Greenspan, L. (1977). "Humidity fixed points of binary staurated aqueous solutions." Journal of Research of the National Bureau of Standards - A, Physics and Chemistry 81A(1): 89-96.
    • 26. Apelblat, A. (1992). "The vapour pressures of water over saturated aqueous solutions of barium chloride, magnesium nitrate, calcium nitrate, potassium carbonate, and zinc sulfate, at temperatures from 283 K to 313 K." The Journal of Chemical Thermodynamics 24(6): 619-626 28. Tan, A., Simovic, S., Davey, A.K., Rades, T., Prestidge, C.A. (2009) Silica lipid hybrid (SLH) microcapsules: A novel oral delivery system for poorly soluble drugs. Journal of Controlled Release 134 62-70.
    • 30. Ghorab, D. M., Amin, M. M., Khowessah, O. M., Tadros, M. I. (2011) Colon-targeted celecoxibloaded Eudragit® S100-coated poly- ε-caprolactone microparticles: Preparation, characterization and in vivo evaluation in rats. Drug Delivery 18 (7) 523-535.
    • 31. Leonardi, D., Barrera, M. G., Lamas, M. C., Salomón, C. J. (2007) Development of prednisone: Polyethylene glycol 6000 fast-release tablets from solid dispersions: Solid-state characterization, dissolution behavior, and formulation parameters. AAPS PharmSciTech 8(4): 221-228
    • 32. Pathak, D., Dahiya, S., Pathak, K. (2008) Solid dispersion of meloxicam: Factorially designed dosage form for geriatric population. Acta Pharmaceutica 58(1): 99-110
    • 33. Ghareeb, M. M., Abdulrasool, A. A., Hussein, A. A., Noordin, M. I. (2009) Kneading Technique for Preparation of Binary Solid Dispersion of Meloxicam with Poloxamer 188. AAPS PharmSciTech 10(4): 1206-1215
    • 34. O'Neill, M., Smith, A., Heckelman, P.E., Budavari, S., eds. (2001). The Merck Index, Whitehouse Station, NK, Merk & Co.Inc.
    • 35. Van den Mooter, G., Augustijns, P., Blaton, N., Kinget, R. (1998) Physico-chemical characterization of solid dispersions of temazepam with polyethylene glycol 6000 and PVP K30. International Journal of Pharmaceutics 164(1-2): 67-80. 43. Shah, J., Vasanti, S., Anroop, B., Vyas, H. (2009) Enhancement of dissolution rate of valdecoxib by solid dispersions technique with PVP K 30 & PEG 4000: preparation and in vitro evaluation. Journal of Inclusion Phenomena and Macrocyclic Chemistry 63(1-2): 69-75.
    • 46. Sharma, S., Sher, P., Badve, S., Pawar, A. P. (2005) Adsorption of meloxicam on porous calcium silicate: Characterization and tablet formulation. AAPS PharmSciTech 6(4): E618-E625.
    • 47. Ito, Y., Arai, H., Uchino, K., Iwasaki, K., Shibata, N., Takada, K. (2005a) Effect of adsorbents on the absorption of lansoprazole with surfactant." International Journal of Pharmaceutics 289(1-2): 69-77.
    • 48. Ito, Y., Kusawake, T., Ishida, M., Tawa, R., Shibata, N., Takada, K. (2005b) Oral solid gentamicin preparation using emulsifier and adsorbent. Journal of Controlled Release 105(1-2): 23-31.
    • 59. Malamataris, S., Goidas, P., Dimitriou, A. (1991) Moisture sorption and tensile strength of some tableted direct compression excipients. International Journal of Pharmaceutics 68 51-60
    • 60. Amidon, G. E., Houghton, M. E. (1995) The effect of moisture on the mechanical and powder flow properties of microcrystalline cellulose. Pharmaceutical Research 12 923-929 3.72±0.18 1.1079±0.96 0.0863±0.01
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