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Ennaceur, Abdelkader; Mostafa, Randa (2002)
Publisher: John Wiley & Sons
Languages: English
Types: Article
Subjects: sub_cognitivebehaviour, sub_neuropsychology, sub_biomedicalsciences
In the present report we describe a 3-D maze spatial navigation task for rats based on a modification of an eight-arm radial maze. The arms radiating from a central platform can be presented in a horizontal plane either raised 10 cm above the level of a central platform or lowered 10 cm below. Memory of visited and non-visited arms can be guided by distinct internal cues (patterns) that are presented on panels set at the end of each arm. Rats are trained in three different maze configurations (eight session each) with arms set lowered, flattened or raised relative to a central platform. A food pellet is placed at the end of each arm and rats are allowed to make eight arm choices only, in each testing session. In this task rats perform better when moving uphill to raised arms than when moving on flattened arms or when moving downhill to lowered arms. It is likely that spatial navigation on raised arms is based on visual cues that were highly visible from the central platform. This result can be accounted for by the position of the rats' eyes that are placed laterally on the sides of their heads.
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    • 1. Barnes C.A. (1979) Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J. Comp. Physiol. Psychol. 93: 74-104
    • 2. Block M.T. (1969) A note on the refraction and image formation of the rat's eye. Vision Res. 9: 705-11
    • 3. Buresova O., Bures J. (1982) Radial maze as a tool for assessing the effect of drugs on the working memory of rats. Psychopharmacol. 77: 268-71
    • 4. Ennaceur A. (1998) Effects of lesions of the substantia innominata/ventral pallidum, globus pallidus and medial septum in object recognition and radial-maze tasks: physostigmine and amphetamine treatments. Pharmacol. Res. 38: 251-263
    • 5. Ennaceur A., Aggleton J.P., Fray P.J. (1997) Automated visual delayed non-matching to sample task for rats. Neurosci Res Comm 20: 103-111
    • 6. Ennaceur A., Aggleton J.P. (1998) An attempt to overcome the problem of mediating strategies in the delayed nonmatching-to-position task using a novel automated visual memory apparatus. Neurosci. Res. Comm. 22: 153-163
    • 7. Ennaceur A., Meliani K. (1992) Effects of Physostigmine and Scopolamine on rats' performances in object recognition and radial-maze tests. Psychopharmacol. 109: 321-330
    • 8. Gerlai R. (1998) A new continuous alternation task in T-maze detects hippocampal dysfunction in mice: a strain comparison and lesion study. Behav. Brain Res. 95: 91¯ 101
    • 9. Hogg S. (1996) A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol. Biochem. Behav. 54: 21-30
    • 10. Jarrard L.E. (1983) Selective hippocampal lesions and behavior: effects of kainic acid lesions on performance of place and cue tasks. Behav. Neurosci. 97: 873-89
    • 11. MHarzi M., Jarrard L.E. (1992) Strategy selection in a task with spatial and nonspatial components: Effects of fimbria-fornix lesions in rats. Behav. Neural Biol. 58:171-179
    • 12. Molinengo L., Ricci-Gamalero S. (1965) Stair-step maze for the study of simple associations. Boll. Soc. Ital. Biol. Sper. 41: 501-504
    • 13. Mostafa R.M., Ennaceur A. (2001) A 3D spatial memory navigation task for rats and mice. Soc. Neurosci. Abstr. 27: 1417
    • 14. Olton D.S., Feustle W.A. (1981) Hippocampal function required for nonspatial working memory. Exp. Brain Res. 41: 380-9
    • 15. Passino E., Ammassari-Teule M. (1999) Visual discrimination in inbred mice: strain-specific involvement of hippocampal regions. Physiol. & Behav. 67: 393-399
    • 16. Pellow S., Chopin P., File S.E., Briley M. (1985) Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods 14: 149-67
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