LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Stockinger , Brigitta B; Hirota , Keiji; Stieglitz , Benjamin; Van Snick , Jacques; Tolaini , Mauro; Sparwasser , Tim; Helmby , Helena; Lahl , Katharina; Wilhelm , Christoph (2011)
Publisher: Nature Publishing Group
Languages: English
Types: Article
Subjects: Innate immunity, Inflammation, Allergy, Cytokines, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, Article
Abstract Interleukin 9 (IL-9) is a cytokine implicated in lung inflammation, but its cellular origin and function remain unclear. Here we describe a reporter mouse strain designed to fate map cells that have activated IL-9. We show that during papain-induced lung inflammation IL-9 production was largely restricted to innate lymphoid cells (ILC). IL-9 production by ILC was dependent on IL-2 from adaptive immune cells and was rapidly lost in favor of other cytokines, such as IL-13 and IL-5. Blockade of IL-9 production via neutralizing antibodies substantially reduced IL-13 and IL-5, suggesting that ILC provide the missing link between the well-established functions of IL-9 on the regulation of TH2 cytokines and responses. (Stockinger, Brigitta B) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Stockinger, Brigitta B) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Hirota, Keiji) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Stieglitz, Benjamin) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (van Snick, Jacques) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Tolaini, Mauro) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Sparwasser, Tim) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Helmby, Helena) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Lahl, Katharina) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Wilhelm, Christoph) UNITED KINGDOM Accepted: 2011-09-06 Received: 2011-04-26 Revised: 2011-09-06