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Stockinger , Brigitta B; Hirota , Keiji; Stieglitz , Benjamin; Van Snick , Jacques; Tolaini , Mauro; Sparwasser , Tim; Helmby , Helena; Lahl , Katharina; Wilhelm , Christoph (2011)
Publisher: Nature Publishing Group
Journal: Nature immunology
Languages: English
Types: Article
Subjects: Innate immunity, Inflammation, Allergy, Cytokines, Article, [ SDV.IMM ] Life Sciences [q-bio]/Immunology
Interleukin 9 (IL-9) is a cytokine linked to lung inflammation, but its cellular origin and function remain unclear. Here we describe a reporter mouse strain designed to map the fate of cells that have activated IL-9. We found that during papain-induced lung inflammation, IL-9 production was largely restricted to innate lymphoid cells (ILCs). IL-9 production by ILCs depended on IL-2 from adaptive immune cells and was rapidly lost in favor of other cytokines, such as IL-13 and IL-5. Blockade of IL-9 production via neutralizing antibodies resulted in much lower expression of IL-13 and IL-5, which suggested that ILCs provide the missing link between the well-established functions of IL-9 in the regulation of type 2 helper T cell cytokines and responses.