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Rmali, Khaled Ali Ramadan
Languages: English
Types: Doctoral thesis
Subjects: RC0254
The study has further shown that IL-1[Special character omitted] is a potential regulator of TEM-8 expression in tumours and that IL-1[Special character omitted] significantly induced the formation of capillary-like tubules from the HECV cells, accompanied by an increase in TEM-8 expression. Where as, elimination of TEM-8 by way of ribozyme transgene significantly decreased the formation of capillary-like tubules and the mobility of HECV cells. Moreover we have demonstrated that the vW domain together with trans-membrane domain of TEM-8 are the structural domain that are responsible for the tubule forming action of TEM-8, using expression construct in varying cell lines.

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