Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Yeomans, M R; Re, R; Wickham, M; Lundholm, H; Chambers, L (2016)
Publisher: Nature Publishing Group
Languages: English
Types: Article
Subjects: B

Classified by OpenAIRE into

mesheuropmc: digestive, oral, and skin physiology
Background/Objectives: Consumption of high-energy beverages has been implicated as a risk factor for weight gain, yet why nutrients ingested as beverages fail to generate adequate satiety remains unclear. In general consumers do not expect drinks to be satiating, but drinks generate greater satiety when their sensory characteristics imply they may be filling. These findings challenge traditional bottom-up models of how gut-based satiety signals modify behavior to suggest that beliefs at the point of ingestion modify gut-based satiety signaling.\ud \ud Subjects/Methods: Healthy volunteers (n = 23) consumed four different beverages, combining an overt sensory manipulation (thin, Low Sensory, LS, or thicker and more creamy, Enhanced Sensory, ES) and covert nutrient manipulation (low energy, LE, 78kcal; high energy, HE, 267 kcal) on different days. Effects on satiety were assessed through rated appetite and levels of glucose, insulin, pancreatic polypeptide (PP) and cholesystokinin (CCK) recorded periodically over 90 minutes, and through intake at an ad libitum test lunch.\ud \ud Results: Intake at the test lunch and rated appetite were both altered by both the sensory and nutrient manipulations, with lowest intake and greatest suppression of hunger post-drink in the ESHE condition. Insulin increased more after HE than LE drinks, and after ES than LS drinks, while PP levels were higher after ES than LS versions. CCK levels only increased after the ESHE drink.\ud \ud Conclusions: These data confirm acute sensitivity of satiety after consuming a drink both to the sensory characteristics and nutrient content of the drink, and suggest that this may be at least in part due to top-down modulation of release of satiety-related gut hormones.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. School of Psychology, University of Sussex, Brighton, BN1 9QH 2. World Sugar Research Organisation, 3. Nutrition Research, Leatherhead Food Research, Randalls Road, Leatherhead, Surrey KT22 7RY, UK 4. British Nutrition Foundation, Imperial House 6th Floor, 15-19 Kingsway, London WC2B 6UN 1.
    • Hill JO, Wyatt HR, Peters JC. Energy balance and obesity. Circulation 2012; 126(1): 126-132.
    • Sclafani A, Ackroff K. Role of gut nutrient sensing in stimulating appetite and conditioning food preferences. American Journal of PhysiologyRegulatory, Integrative and Comparative Physiology 2012; 302(10): R1119-R1133.
    • Sam AH, Troke RC, Tan TM, Bewick GA. The role of the gut/brain axis in modulating food intake. Neuropharmacology 2012; 63(1): 46-56.
    • Hussain S, Bloom S. The regulation of food intake by the gut-brain axis: implications for obesity. Int J Obesity 2013; 37(5): 625-633.
    • Hellström PM. Satiety signals and obesity. Current opinion in gastroenterology 2013; 29(2): 222-227.
    • Perry B, Wang Y. Appetite regulation and weight control: the role of gut hormones. Nutrition & diabetes 2012; 2(1): e26.
    • Holzer P, Reichmann F, Farzi A. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis. Neuropeptides 2012; 46(6): 261-274.
    • Stubbs J, Whybrow S. Beverages, appetite and energy balance. In: Wilson T, Temple NJ (eds). Beverages in Nutrition and Health. Humana Press: Totowa, NJ, 2003, pp 261-278.
    • de Graaf C. Why liquid energy results in overconsumption. P Nutr Soc 2011; (70): 2.
    • Mattes R. Soup and satiety. Physiology and Behavior 2005; 83(5): 739-47.
    • Pavlov IP, Gantt WH, Volborth G, Cannon WB. Conditioned reflexes and psychiatry, vol. 2. International publishers New York, 1941.
    • Woods SC. The eating paradox: how we tolerate food. Psychological Review 1991; 98(4): 488-505.
    • Teff KL, Mattes RD, Engelman K. Cephalic phase insulin release in normal weight males: verification and reliability. Am J Physiol 1991; 261(24): E430-E436.
    • 20 40 60 80 Time after preload (minutes) 20 40 60 80 Time after preload (minutes)
  • No related research data.
  • No similar publications.

Share - Bookmark

Funded by projects

  • RCUK | Maximising satiety through...

Cite this article