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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Palka, Barbara Paulina
Languages: English
Types: Doctoral thesis
Subjects: RE

Classified by OpenAIRE into

mesheuropmc: carbohydrates (lipids), sense organs, eye diseases
Transmission electron microscopy of a human cornea with excess chondroitin sulphate/dermatan sulphate glycosaminoglycan showed that changes in proteoglycan structure, content and sulphation lead to the formation of abnormally large collagen fibrils. The lack of sulphation of keratin sulphate in MCD also led to abnormally large fibrils, which are present in the deep stromal layers. These findings suggest overlapping roles of the two proteoglycan populations in the corneal stroma with possible feedback mechanisms, too. Taken together, the findings of this thesis indicate the central role played by proteoglycan-collagen interactions in the development and maintenance of properly formed corneal stroma.
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