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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Millington, Steven Andrew (2008)
Languages: English
Types: Unknown
Osteoarthritis and degenerative cartilage diseases affect millions of people. Therefore, there is huge interest in developing new therapies to repair, replace and/or regenerate cartilage. This necessitates advances in techniques which make earlier non-invasive diagnosis and objective quantitative evaluations of new therapies possible. Most previous research has focused on the knee and neglected the ankle joint. Hence, the aims of this thesis are to describe and quantify the geometric properties of ankle cartilage, to evaluate joint contact characteristics and develop techniques which allow quantitative measurements to be made in vivo. Chapters 3 and 6 describe the application of a high resolution stereophotography system for making highly accurate 3-D geometric models from which quantitative measurements of cartilage parameters and joint area contact can be made. Chapters 4 and 5 report the testing of image analysis algorithms designed to segment cartilage sensitive MR images. Work focused on initially on a semi-automated 2-D segmentation approach and subsequently on a pilot study of 3-D automated segmentation algorithm. The stereophotographic studies were highly accurately and demonstrated that ankle cartilage thickness is greater than previously reported with the thickest cartilage occurring where cartilage injuries are most commonly seen. Furthermore, joint contact area is larger than previously believed and corresponds to the regions of the thickest cartilage over the talar shoulders. The image analysis studies show that it is possible to accurately and reproducibly segment the thin cartilage layers of the ankle joint using a semi-automated approach. The feasibility of a fully automated 3D method for future clinical use is also shown. In conclusion this thesis presents novel methods for examining ankle articular cartilage in vitro and in vivo, showing that the thickest cartilage occurs in highly curved regions over the shoulders of the talus which correspond to regions of greatest contact. Importantly, the image analysis techniques may be used for future clinical monitoring of patients sustaining cartilage injuries or undergoing cartilage repair therapies.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • Acton, S. T., Bovik, A. C., (1998). Order statistics in image processing. In: Balakrishnan, N., Rao, C. R. (Eds.), Handbook of Statistics 17: Order Statistics and Their Applications. Elsevier Science, New York, pp. 603-641.
    • Acton, S. T., Wei, D., Bovik, A. C., (1999). Image enhancement. In: Webster, J. (Ed.), Encyclopedia of Electrical and Electronics Engineering. Wiley - Interscience, New York.
    • Adam, C., Eckstein, F., Milz, S., Putz, R., (1998a). The distribution of cartilage thickness within the joints of the lower limb of elderly individuals. J.Anat. 193 ( Pt 2), 203-214.
    • Adam, C., Eckstein, F., Milz, S., Schulte, E., Becker, C., Putz, R., (1998b). The distribution of cartilage thickness in the knee-joints of old-aged individuals -- measurement by A-mode ultrasound. Clin.Biomech.(Bristol., Avon.) 13, 1-10.
    • Al Ali, D., Graichen, H., Faber, S., Englmeier, K. H., Reiser, M., Eckstein, F., (2002). Quantitative cartilage imaging of the human hind foot: precision and inter-subject variability. J.Orthop.Res. 20, 249-256.
    • Anderson, D. D., Goldsworthy, J. K., Shivanna, K., Grosland, N. M., Pedersen, D. R., Thomas, T. P., Tochigi, Y., Marsh, J. L., Brown, T. D., (2006). Intra-articular contact stress distributions at the ankle throughout stance phase-patient-specific finite element analysis as a metric of degeneration propensity. Biomech.Model.Mechanobiol. 5, 82-89.
    • Ateshian, G. A., (1993). A B-spline least-squares surface-fitting method for articular surfaces of diarthrodial joints. J.Biomech.Eng 115, 366-373.
    • Ateshian, G. A., Kwak, S. D., Soslowsky, L. J., Mow, V. C., (1994). A stereophotogrammetric method for determining in situ contact areas in diarthrodial joints, and a comparison with other methods. Journal of Biomechanics 27, 111- 124.
    • Ateshian, G. A., Soslowsky, L. J., Mow, V. C., (1991). Quantitation of articular surface topography and cartilage thickness in knee joints using stereophotogrammetry. Journal of Biomechanics 24, 761-776.
    • Ateshian, G. A., Warden, W. H., Kim, J. J., Grelsamer, R. P., Mow, V. C., (1997). Finite deformation biphasic material properties of bovine articular cartilage from confined compression experiments. Journal of Biomechanics 30, 1157-1164.
    • Athanasiou, K. A., Niederauer, G. G., Schenck, R. C., Jr., (1995). Biomechanical topography of human ankle cartilage. Ann.Biomed.Eng 23, 697-704.
    • Atkinson, T. S., Haut, R. C., Altiero, N. J., (1998). Impact-induced fissuring of articular cartilage: an investigation of failure criteria. J.Biomech.Eng 120, 181-187.
    • Ba-Ssalamah, A., Schibany, N., Puig, S., Herneth, A. M., Noebauer-Huhmann, I. M., Trattnig, S., (2002). Imaging articular cartilage defects in the ankle joint with 3D fat-suppressed echo planar imaging: comparison with conventional 3D fatsuppressed gradient echo imaging. J.Magn Reson.Imaging 16, 209-216.
    • Bashir, A., Gray, M. L., Boutin, R. D., Burstein, D., (1997). Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. Radiology 205, 551-558.
    • Bashir, A., Gray, M. L., Hartke, J., Burstein, D., (1999). Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson.Med. 41, 857-865.
    • Black, J. D., Matejczyk, M. B., Greenwald, A. S., (1981). Reversible cartilage staining technique for defining articular weight-bearing surfaces. Clinical Orthopaedics and Related Research 265-267.
    • Borrelli, J., Jr., Tinsley, K., Ricci, W. M., Burns, M., Karl, I. E., Hotchkiss, R., (2003). Induction of chondrocyte apoptosis following impact load. J.Orthop.Trauma 17, 635-641.
    • Brittberg, M., Lindahl, A., Nilsson, A., Ohlsson, C., Isaksson, O., Peterson, L., (1994). Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N.Engl.J.Med. 331, 889-895.
    • Brown, T. D., Anderson, D. D., Nepola, J. V., Singerman, R. J., Pedersen, D. R., Brand, R. A., (1988). Contact stress aberrations following imprecise reduction of simple tibial plateau fractures. J.Orthop.Res. 6, 851-862.
    • Buckwalter, J. A., (1992). Mechanical injuries of articular cartilage. In: Finerman, G. (Ed.), Biology and biomechanics of te traumatised synovial joint. American Academy of Orthopaedic Surgeons, Park Ridge, IL, pp. 83-96.
    • Buckwalter, J. A., (1995). Osteoarthritis and articular cartilage use, disuse, and abuse: experimental studies. J.Rheumatol.Suppl 43, 13-15.
    • Buckwalter, J. A., (2002). Articular cartilage injuries. Clinical Orthopaedics and Related Research 21-37.
    • Buckwalter, J. A., Mankin, H. J., (1997). Articular cartilage .2. Degeneration and osteoarthrosis, repair, regeneration, and transplantation. Journal of Bone and Joint Surgery-American Volume 79A, 612-632.
    • Buckwalter, J. A., Martin, J., Mankin, H. J., (2000). Synovial joint degeneration and the syndrome of osteoarthritis. Instr.Course Lect. 49, 481-489.
    • Buckwalter, J. A., Saltzman, C. L., (1999). Ankle osteoarthritis: distinctive characteristics. Instr.Course Lect. 48, 233-241.
    • Burgkart, R., Glaser, C., Hinterwimmer, S., Hudelmaier, M., Englmeier, K. H., Reiser, M., Eckstein, F., (2003). Feasibility of T and Z scores from magnetic resonance imaging data for quantification of cartilage loss in osteoarthritis. Arthritis Rheum. 48, 2829-2835.
    • Burgkart, R., Glaser, C., Hyhlik-Durr, A., Englmeier, K. H., Reiser, M., Eckstein, F., (2001). Magnetic resonance imaging-based assessment of cartilage loss in severe osteoarthritis: accuracy, precision, and diagnostic value. Arthritis Rheum. 44, 2072-2077.
    • Burstein, D., Gray, M., (2003). New MRI techniques for imaging cartilage. Journal of Bone and Joint Surgery 85-A Suppl 2, 70-77.
    • Calhoun, J. H., Li, F., Ledbetter, B. R., Viegas, S. F., (1994). A comprehensive study of pressure distribution in the ankle joint with inversion and eversion. Foot Ankle Int. 15, 125-133.
    • Chen, C. T., Burton-Wurster, N., Borden, C., Hueffer, K., Bloom, S. E., Lust, G., (2001). Chondrocyte necrosis and apoptosis in impact damaged articular cartilage. J.Orthop.Res. 19, 703-711.
    • Cheung, J. T., Zhang, M., (2005). A 3-dimensional finite element model of the human foot and ankle for insole design. Arch.Phys.Med.Rehabil. 86, 353-358.
    • Choung, D., Christensen, J. C., (2002). Mosaicplasty of the talus: a joint contact analysis in a cadaver model. J.Foot Ankle Surg. 41, 65-75.
    • Christensen, J. C., Driscoll, H. L., Tencer, A. F., (1994). 1994 William J. Stickel Gold Award. Contact characteristics of the ankle joint. Part 2. The effects of talar dome cartilage defects. J.Am.Podiatr.Med.Assoc. 84, 537-547.
    • Cohen, Z. A., McCarthy, D. M., Kwak, S. D., Legrand, P., Fogarasi, F., Ciaccio, E. J., Ateshian, G. A., (1999). Knee cartilage topography, thickness, and contact areas from MRI: in-vitro calibration and in-vivo measurements. Osteoarthritis.Cartilage. 7, 95-109.
    • Cohen, Z. A., Mow, V. C., Henry, J. H., Levine, W. N., Ateshian, G. A., (2003). Templates of the cartilage layers of the patellofemoral joint and their use in the assessment of osteoarthritic cartilage damage. Osteoarthritis.Cartilage. 11, 569- 579.
    • Corazza, F., Stagni, R., Castelli, V. P., Leardini, A., (2005). Articular contact at the tibiotalar joint in passive flexion. Journal of Biomechanics 38, 1205-1212.
    • Craig, J. G., Go, L., Blechinger, J., Hearshen, D., Bouffard, J. A., Diamond, M., van Holsbeeck, M. T., (2005). Three-tesla imaging of the knee: initial experience. Skeletal Radiol. 34, 453-461.
    • Cushnaghan, J., Dieppe, P., (1991). Study of 500 patients with limb joint osteoarthritis. I. Analysis by age, sex, and distribution of symptomatic joint sites. Ann.Rheum.Dis. 50, 8-13.
    • DeCoster, T. A., Willis, M. C., Marsh, J. L., Williams, T. M., Nepola, J. V., Dirschl, D. R., Hurwitz, S. R., (1999). Rank order analysis of tibial plafond fractures: does injury or reduction predict outcome? Foot Ankle Int. 20, 44-49.
    • Dieppe, P., Kirwan, J., (1994). The localization of osteoarthritis. British Journal of Rheumatology 33, 201-203.
    • Donohue, J. M., Buss, D., Oegema, T. R., Jr., Thompson, R. C., Jr., (1983). The effects of indirect blunt trauma on adult canine articular cartilage. Journal of Bone and Joint Surgery 65, 948-957.
    • Driscoll, H. L., Christensen, J. C., Tencer, A. F., (1994). Contact characteristics of the ankle joint. Part 1. The normal joint. J.Am.Podiatr.Med.Assoc. 84, 491-498.
    • Eckstein, F., Adam, C., Sittek, H., Becker, C., Milz, S., Schulte, E., Reiser, M., Putz, R., (1997). Non-invasive determination of cartilage thickness throughout joint surfaces using magnetic resonance imaging. Journal of Biomechanics 30, 285-289.
    • Eckstein, F., Charles, H. C., Buck, R. J., Kraus, V. B., Remmers, A. E., Hudelmaier, M., Wirth, W., Evelhoch, J. L., (2005b). Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T. Arthritis Rheum. 52, 3132-3136.
    • Eckstein, F., Charles, H. C., Buck, R. J., Kraus, V. B., Remmers, A. E., Hudelmaier, M., Wirth, W., Evelhoch, J. L., (2005a). Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T. Arthritis Rheum. 52, 3132-3136.
    • Eckstein, F., Gavazzeni, A., Sittek, H., Haubner, M., Losch, A., Milz, S., Englmeier, K. H., Schulte, E., Putz, R., Reiser, M., (1996). Determination of knee joint cartilage thickness using three-dimensional magnetic resonance chondro-crassometry (3D MR-CCM). Magn Reson.Med. 36, 256-265.
    • Eckstein, F., Glaser, C., (2004). Measuring cartilage morphology with quantitative magnetic resonance imaging. Semin.Musculoskelet.Radiol. 8, 329-353.
    • Eckstein, F., Heudorfer, L., Faber, S. C., Burgkart, R., Englmeier, K. H., Reiser, M., (2002). Long-term and resegmentation precision of quantitative cartilage MR imaging (qMRI). Osteoarthritis.Cartilage. 10, 922-928.
    • Eckstein, F., Hudelmaier, M., Wirth, W., Kiefer, B., Jackson, R., Yu, J., Eaton, C., Schneider, E., (2005c). Double Echo Steady State (DESS) Magnetic Resonance Imaging of Knee Articular Cartilage at 3 Tesla - a Pilot Study for the Osteoarthritis Initiative. Ann.Rheum.Dis.
    • Eckstein, F., Reiser, M., Englmeier, K. H., Putz, R., (2001a). In vivo morphometry and functional analysis of human articular cartilage with quantitative magnetic resonance imaging--from image to data, from data to theory. Anat.Embryol.(Berl) 203, 147-173.
    • Eckstein, F., Schnier, M., Haubner, M., Priebsch, J., Glaser, C., Englmeier, K. H., Reiser, M., (1998a). Accuracy of cartilage volume and thickness measurements with magnetic resonance imaging. Clinical Orthopaedics and Related Research 137-148.
    • Eckstein, F., Sittek, H., Milz, S., Putz, R., Reiser, M., (1994). The morphology of articular cartilage assessed by magnetic resonance imaging (MRI). Reproducibility and anatomical correlation. Surg.Radiol.Anat. 16, 429-438.
    • Eckstein, F., Sittek, H., Milz, S., Schulte, E., Kiefer, B., Reiser, M., Putz, R., (1995). The potential of magnetic resonance imaging (MRI) for quantifying articular cartilage thickness -- a methodological study. Clin.Biomech.(Bristol., Avon.) 10, 434-440.
    • Eckstein, F., Westhoff, J., Sittek, H., Maag, K. P., Haubner, M., Faber, S., Englmeier, K. H., Reiser, M., (1998b). In vivo reproducibility of three-dimensional cartilage volume and thickness measurements with MR imaging. AJR Am.J.Roentgenol. 170, 593-597.
    • Eckstein, F., Winzheimer, M., Hohe, J., Englmeier, K. H., Reiser, M., (2001b). Interindividual variability and correlation among morphological parameters of knee joint cartilage plates: analysis with three-dimensional MR imaging. Osteoarthritis.Cartilage. 9, 101-111.
    • Eyre, D. R., (1980). Collagen: molecular diversity in the body's protein scaffold. Science 207, 1315-1322.
    • Faber, S. C., Eckstein, F., Lukasz, S., Muhlbauer, R., Hohe, J., Englmeier, K. H., Reiser, M., (2001). Gender differences in knee joint cartilage thickness, volume and articular surface areas: assessment with quantitative three-dimensional MR imaging. Skeletal Radiol. 30, 144-150.
    • Ferrari, J., Hopkinson, D. A., Linney, A. D., (2004). Size and shape differences between male and female foot bones: is the female foot predisposed to hallux abducto valgus deformity? J.Am.Podiatr.Med.Assoc. 94, 434-452.
    • Fitzpatrick, D. C., Otto, J. K., McKinley, T. O., Marsh, J. L., Brown, T. D., (2001). Dynamic contact stress aberrations after simulateed posterior malleolar fracture of the ankle. In Transactions of the orthopaedic trauma association. Orthopaedic Trauma Association, San Diego, CA.
    • Fitzpatrick, D. C., Otto, J. K., McKinley, T. O., Marsh, J. L., Brown, T. D., (2004). Kinematic and contact stress analysis of posterior malleolus fractures of the ankle. Journal of Orthopaedic Trauma 18, 271-278.
    • Fleishman, S., Drori, I., Cohen-Or, D., (2003). Bilateral mesh denoising. In SIGGRAPH. Assoc. for Computing Machinary, San Diego.
    • Fukubayashi, T., Kurosawa, H., (1980). The contact area and pressure distribution pattern of the knee. A study of normal and osteoarthrotic knee joints. Acta Orthop.Scand. 51, 871-879.
    • Greenwald, A. S., Matejczyk, M. B., Keppler, L., Black, J. D., Moran, J. M., Porritt, D., Beck, R. D., Wilde, A. H., (1977). Articular cartilage contact areas of the ankle. Orthopaedic Research Society, Las Vegas, Nevada.
    • Hall, F. M., Wyshak, G., (1980). Thickness of articular cartilage in the normal knee. Journal of Bone and Joint Surgery 62, 408-413.
    • Han, B., Cole, A. A., Shen, Y., Brodie, T., Williams, J. M., (2002). Early alterations in the collagen meshwork and lesions in the ankles are associated with spontaneous osteoarthritis in guinea-pigs. Osteoarthritis.Cartilage. 10, 778-784.
    • Hangody, L., (2003). The mosaicplasty technique for osteochondral lesions of the talus. Foot Ankle Clin. 8, 259-273.
    • Hangody, L., Feczko, P., Bartha, L., Bodo, G., Kish, G., (2001). Mosaicplasty for the treatment of articular defects of the knee and ankle. Clin.Orthop.Relat Res. S328- S336.
    • Hangody, L., Kish, G., Karpati, Z., Udvarhelyi, I., Szigeti, I., Bely, M., (1998). Mosaicplasty for the treatment of articular cartilage defects: application in clinical practice. Orthopedics 21, 751-756.
    • Hargreaves, B. A., Gold, G. E., Beaulieu, C. F., Vasanawala, S. S., Nishimura, D. G., Pauly, J. M., (2003). Comparison of new sequences for high-resolution cartilage imaging. Magn Reson.Med. 49, 700-709.
    • Haubner, M., Eckstein, F., Schnier, M., Losch, A., Sittek, H., Becker, C., Kolem, H., Reiser, M., Englmeier, K. H., (1997). A non-invasive technique for 3-dimensional assessment of articular cartilage thickness based on MRI. Part 2: Validation using CT arthrography. Magn Reson.Imaging 15, 805-813.
    • Haut, R. C., (1989). Contact pressures in the patellofemoral joint during impact loading on the human flexed knee. J.Orthop.Res. 7, 272-280.
    • Haut, R. C., Ide, T. M., De Camp, C. E., (1995). Mechanical responses of the rabbit patello-femoral joint to blunt impact. J.Biomech.Eng 117, 402-408.
    • Heidemann, R. M., Griswold, M. A., Muller, M., Breuer, F., Blaimer, M., Kiefer, B., Schmitt, M., Jakob, P. M., (2004). [Feasibilities and limitations of high field parallel MRI]. Radiologe 44, 49-55.
    • Huber-Betzer, H., Brown, T. D., Mattheck, C., (1990). Some effects of global joint morphology on local stress aberrations near imprecisely reduced intra-articular fractures. Journal of Biomechanics 23, 811-822.
    • Hyhlik-Durr, A., Faber, S., Burgkart, R., Stammberger, T., Maag, K. P., Englmeier, K. H., Reiser, M., Eckstein, F., (2000). Precision of tibial cartilage morphometry with a coronal water-excitation MR sequence. Eur.Radiol. 10, 297-303.
    • Imhof, H., Nobauer-Huhmann, I. M., Krestan, C., Gahleitner, A., Sulzbacher, I., Marlovits, S., Trattnig, S., (2002). MRI of the cartilage. Eur.Radiol. 12, 2781- 2793.
    • Jeffrey, J. E., Thomson, L. A., Aspden, R. M., (1997). Matrix loss and synthesis following a single impact load on articular cartilage in vitro. Biochim.Biophys.Acta 1334, 223-232.
    • Johnson, K. L., (1985). Contact mechanics. Cambridge University Press, Cambridge.
    • Jonsson, K., Buckwalter, K., Helvie, M., Niklason, L., Martel, W., (1992). Precision of hyaline cartilage thickness measurements. Acta Radiol. 33, 234-239.
    • Jurvelin, J., Kiviranta, I., Arokoski, J., Tammi, M., Helminen, H. J., (1987). Indentation study of the biochemical properties of articular cartilage in the canine knee. Eng Med. 16, 15-22.
    • Jurvelin, J. S., Rasanen, T., Kolmonen, P., Lyyra, T., (1995). Comparison of optical, needle probe and ultrasonic techniques for the measurement of articular cartilage thickness. Journal of Biomechanics 28, 231-235.
    • Karvonen, R. L., Negendank, W. G., Teitge, R. A., Reed, A. H., Miller, P. R., Fernandez-Madrid, F., (1994). Factors affecting articular cartilage thickness in osteoarthritis and aging. J.Rheumatol. 21, 1310-1318.
    • Kempson, G. E., (1979). Mechanical properties of articular cartilage. In: Freeman, M. A. (Ed.), Adult articular cartilage. Pitman Medical, Tunbridge Wells, England, pp. 333-414.
    • Kim, H. A., Lee, Y. J., Seong, S. C., Choe, K. W., Song, Y. W., (2000). Apoptotic chondrocyte death in human osteoarthritis. J.Rheumatol. 27, 455-462.
    • Kim, Y. J., Jaramillo, D., Millis, M. B., Gray, M. L., Burstein, D., (2003). Assessment of early osteoarthritis in hip dysplasia with delayed gadolinium-enhanced magnetic resonance imaging of cartilage. Journal of Bone and Joint Surgery 85-A, 1987-1992.
    • Kimizuka, M., Kurosawa, H., Fukubayashi, T., (1980). Load-bearing pattern of the ankle joint. Contact area and pressure distribution. Arch.Orthop.Trauma Surg. 96, 45-49.
    • Kura, H., Kitaoka, H. B., Luo, Z. P., An, K. N., (1998). Measurement of surface contact area of the ankle joint. Clin.Biomech.(Bristol., Avon.) 13, 365-370.
    • Kurosawa, H., Fukubayashi, T., Nakajima, H., (1980). Load-bearing mode of the knee joint: physical behavior of the knee joint with or without menisci. Clin.Orthop.Relat Res. 283-290.
    • Lane, J. M., Weiss, C., (1975). Review of articular cartilage collagen research. Arthritis Rheum. 18, 553-562.
    • Llinas, A., McKellop, H. A., Marshall, G. J., Sharpe, F., Kirchen, M., Sarmiento, A., (1993). Healing and remodeling of articular incongruities in a rabbit fracture model. Journal of Bone and Joint Surgery 75, 1508-1523.
    • Loening, A. M., James, I. E., Levenston, M. E., Badger, A. M., Frank, E. H., Kurz, B., Nuttall, M. E., Hung, H. H., Blake, S. M., Grodzinsky, A. J., Lark, M. W., (2000). Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis. Arch.Biochem.Biophys. 381, 205-212.
    • Losch, A., Eckstein, F., Haubner, M., Englmeier, K. H., (1997). A non-invasive technique for 3-dimensional assessment of articular cartilage thickness based on MRI. Part 1: Development of a computational method. Magn Reson.Imaging 15, 795-804.
    • Lovasz, G., Llinas, A., Benya, P. D., Park, S. H., Sarmiento, A., Luck, J. V., Jr., (1998). Cartilage changes caused by a coronal surface stepoff in a rabbit model. Clinical Orthopaedics and Related Research 224-234.
    • Lukasz, S., Muhlbauer, R., Faber, S., Englmeier, K. H., Reiser, M., Eckstein, F., (1998). [Sex-specific analysis of cartilage volume in the knee joint--a quantitative MRIbased study]. Anat.Anz. 180, 487-493.
    • Macko, V. W., Matthews, L. S., Zwirkoski, P., Goldstein, S. A., (1991). The jointcontact area of the ankle. The contribution of the posterior malleolus. Journal of Bone and Joint Surgery 73, 347-351.
    • Mandelbaum, B. R., Gerhardt, M. B., Peterson, L., (2003). Autologous chondrocyte implantation of the talus. Arthroscopy 19 Suppl 1, 129-137.
    • Mann, R. A., (1993). Biomechanics of the foot and ankle. Surgery of the foot and ankle. C.V. Mosby Co, St Louis, pp. 3-43.
    • Marsh, J. L., Buckwalter, J., Gelberman, R., Dirschl, D., Olson, S., Brown, T., Llinias, A., (2002). Articular fractures: does an anatomic reduction really change the result? Journal of Bone and Joint Surgery 84-A, 1259-1271.
    • Marsh, J. L., williams, T., Nepola, J. V., DeCoster, T. A., Hurwitz, S., Dirschl, D., (1997). Tibial plafond fractures: Does articular reduction and/or injury pattern predict outcome? Orthopaedic Transactions 21, 563.
    • Martin, J. A., Buckwalter, J. A., (2000). The role of chondrocyte-matrix interactions in maintaining and repairing articular cartilage. Biorheology 37, 129-140.
    • Millington, S. A., Grabner, M., Hurwitz, S. R., Crandall, J. R., (2004). A stereophotographic study of ankle cartilage thickness; distribution and surface topography. Osteoarthritis and Cartilage 12, S64.
    • Millington, S. A., Li, B., Tang, J., Trattnig, S., Crandall, J. R., Hurwitz, S. R., Acton, S. T., (2007c). Quantitative and topographical evaluation of ankle articular cartilage using high resolution MRI. J Orthop.Res. 25, 143-151.
    • Minas, T., Nehrer, S., (1997). Current concepts in the treatment of articular cartilage defects. Orthopedics 20, 525-538.
    • Mosher, T. J., Dardzinski, B. J., Smith, M. B., (2000). Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2--preliminary findings at 3 T. Radiology 214, 259-266.
    • Mow, V. C., Ateshian, G. A., (1997). Lubrication and wear of diarthrodial joints. In: Mow, V. C., Hayes, W. C. (Eds.), Basic biomechanics. Lippincott-Raven, Philadelphia, pp. 275-315.
    • Mow, V. C., Ratcliffe, A., (1997). Structure and function of articular cartilage and meniscus. In: Mow, V. C., Hayes, W. C. (Eds.), Basic orthopaedic biomechanics. lippincott-Raven, Philadelphia, pp. 113-177.
    • Mow, V. C., Holmes, M. H., Lai, W. M., (1984). Fluid transport and mechanical properties of articular cartilage: a review. J Biomech. 17, 377-394.
    • Mow, V. C., Kuei, S. C., Lai, W. M., Armstrong, C. G., (1980). Biphasic creep and stress relaxation of articular cartilage in compression? Theory and experiments. J.Biomech.Eng 102, 73-84.
    • H., (1983). Proteoglycans as Biochem.Soc.Trans. 11, 613-622.
    • Patel, V. V., Hall, K., Ries, M., Lindsey, C., Ozhinsky, E., Lu, Y., Majumdar, S., (2003). Magnetic resonance imaging of patellofemoral kinematics with weightbearing. Journal of Bone and Joint Surgery 85-A, 2419-2424.
    • Peterfy, C. G., van Dijke, C. F., Janzen, D. L., Gluer, C. C., Namba, R., Majumdar, S., Lang, P., Genant, H. K., (1994). Quantification of articular cartilage in the knee with pulsed saturation transfer subtraction and fat-suppressed MR imaging: optimization and validation. Radiology 192, 485-491.
    • Peterfy, C. G., van Dijke, C. F., Lu, Y., Nguyen, A., Connick, T. J., Kneeland, J. B., Tirman, P. F., Lang, P., Dent, S., Genant, H. K., (1995). Quantification of the volume of articular cartilage in the metacarpophalangeal joints of the hand: accuracy and precision of three-dimensional MR imaging. AJR Am.J.Roentgenol. 165, 371-375.
    • Pilch, L., Stewart, C., Gordon, D., Inman, R., Parsons, K., Pataki, I., Stevens, J., (1994). Assessment of cartilage volume in the femorotibial joint with magnetic resonance imaging and 3D computer reconstruction. J.Rheumatol. 21, 2307-2321.
    • Poole, A. R., Kojima, T., Yasuda, T., Mwale, F., Kobayashi, M., Laverty, S., (2001). Composition and structure of articular cartilage - A template for tissue repair. Clinical Orthopaedics and Related Research S26-S33.
    • Pratt, W., (1978). Digital Image Processing. Wiley, New York, pp. 495-501.
    • Ratcliffe, A., Tyler, J. A., Hardingham, T. E., (1986). Articular cartilage cultured with interleukin 1. Increased release of link protein, hyaluronate-binding region and other proteoglycan fragments. Biochem.J 238, 571-580.
    • Recht, M., Bobic, V., Burstein, D., Disler, D., Gold, G., Gray, M., Kramer, J., Lang, P., McCauley, T., Winalski, C., (2001). Magnetic resonance imaging of articular cartilage. Clinical Orthopaedics and Related Research S379-S396.
    • Repo, R. U., Finlay, J. B., (1977). Survival of articular cartilage after controlled impact. Journal of Bone and Joint Surgery 59, 1068-1076.
    • Whittaker, J. P., Smith, G., Makwana, N., Roberts, S., Harrison, P. E., Laing, P., Richardson, J. B., (2005). Early results of autologous chondrocyte implantation in the talus. J.Bone Joint Surg.Br. 87, 179-183.
    • Wilson, M. G., Michet, C. J., Jr., Ilstrup, D. M., Melton, L. J., III, (1990). Idiopathic symptomatic osteoarthritis of the hip and knee: a population-based incidence study. Mayo Clin.Proc. 65, 1214-1221.
    • Woo, S. L. Y., Mow, V. C., Lai, W. M., (1987). Biomechanical properties of articular cartilage. Handbook of bioengineering. McGraw-Hill, New York, p. 4.1-4.44.
    • Yao, J. Q., Seedhom, B. B., (1991). A new technique for measuring contact areas in human joints--the '3S technique'. Proc.Inst.Mech.Eng [H.] 205, 69-72.
    • Yao, J. Q., Seedhom, B. B., (1993). Mechanical conditioning of articular cartilage to prevalent stresses. British Journal of Rheumatology 32, 956-965.
    • Yao, J. Q., Seedhom, B. B., (1999). Ultrasonic measurement of the thickness of human articular cartilage in situ. Rheumatology.(Oxford) 38, 1269-1271.
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