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Warriner, David R.; Lawford, Patricia; Sheridan, Paul J. (2016)
Publisher: Elmer Press
Journal: Cardiology Research
Languages: English
Types: Article
Subjects: Original Article, Heart failure, Cardiac resynchronization therapy, Handgrip strength

Classified by OpenAIRE into

mesheuropmc: cardiovascular system
Background: A reduction in skeletal muscle performance measured\ud by handgrip strength is common in heart failure. No trial has investigated\ud the role of cardiac resynchronization therapy, which leads to\ud improvements in cardiac performance, on the function of skeletal\ud muscle in patients with heart failure.\ud Methods: Nineteen patients were recruited, 18 male, age 69 ± 8\ud years, New York Heart Association class II-IV, QRS duration 173 ±\ud 21 ms and left ventricular ejection fraction 26±8%. Handgrip strength\ud was measured at baseline before, and 6 and 12 months, following cardiac\ud resynchronization therapy. Response was assessed using quality\ud of life questionnaire, 6-minute walk distance, left ventricular enddiastolic\ud volume, and cardiopulmonary exercise testing at the same\ud time points.\ud Results: Fourteen patients were identified as responders, demonstrating\ud significant improvements in all four markers of response. There\ud was no significant difference at baseline in left or right handgrip\ud strength between responders and non-responders. Compared to baseline,\ud handgrip strength significantly increased in responders during\ud follow-up, left (34.4 ± 11.4 to 40.3 ± 11.3 kgf, P < 0.001) and right\ud (35.7 ± 12.5 to 42.2 ± 11.5 kgf, P < 0.001) at 12 months. No such\ud improvement was seen in non-responders.\ud Conclusions: This study demonstrates that positive response to cardiac\ud resynchronization therapy is associated with significant gains in\ud handgrip strength, suggesting that cardiac resynchronization therapy\ud may indirectly lead to secondary gains in skeletal muscle function.
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