Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Beeley, J.A.; Yip, H.K.; Stevenson, A. (2000)
Publisher: Nature Publishing Group for the British Dental Association
Languages: English
Types: Article
Subjects: RK

Classified by OpenAIRE into

mesheuropmc: stomatognathic system, stomatognathic diseases
Chemomechanical caries removal involves the chemical softening of carious dentine followed by its removal by gentle excavation. The reagent involved is generated by mixing amino acids with sodium hypochlorite; N-monochloroamino acids are formed which selectively degrade demineralised collagen in carious dentine. The procedure requires 5-15 minutes but avoids the painful removal of sound dentine thereby reducing the need for local anaesthesia. It is well suited to the treatment of deciduous teeth, dental phobics and medically compromised patients. The dentine surface formed is highly irregular and well suited to bonding with composite resin or glass ionomer. When complete caries removal is achieved, the dentine remaining is sound and properly mineralised. The system was originally marketed in the USA in the 1980's as Caridex. Large volumes of solution and a special applicator system were required. A new system, Carisolv, has recently been launched on to the market. This comes as a gel, requires volumes of 0.2-1.0 ml and is accompanied by specially designed instruments.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 0.1M aminobutyric acid glycine 0.1M glutamic acid/leucine/lysine 0.1M NaCI NaCI* 0.1M NaOH NaOH* Ring M E. Dentistry; an Illustrated History. pp 250-251.New York : Abrams, 1985.
    • Frencken J E, Pilot T, Sangpaison Y, Phantumvanit P. Atraumatic restorative treatment (ART): rationale technique and development J Public Health Dent 1996; 56: 135-140.
    • Erbium : YAG laser applications in caries therapy: evaluation of patients perception and acceptance. J Dent 1998: 26; 649-656.
    • Veis A. In Comper W.D. (Ed) Extracellular Matrix, Volume 1 Tissue Function. 41-76 Amsterdam: Harwood Academic Press, 1996.
    • Hall R C, Embery G. The use of immunohistochemistry in understanding the structure and function of the extracellular matrix of dental tissues. Adv Dent Res 1997; 11: 478-486.
    • Van der Rest M, Bruckner P. Collagens: diversity at the molecular and super molecular levels. Curr Opin Struct Biol 1993; 3: 430-436 Thylstrup A, Fejerskov O. Text book of Clinical Cariology. (2nd ed) 111-157. Copenhagan: Munksgaard 1994.
    • Ogushi K, Fusayama T. Electron microscopic structures of two layers of carious dentine. J Dent Res 1975; 54: 1019-1026.
    • Goldman M, Kronman J H. A preliminary report on a chemomechanical means of removing caries J Amer Dent Assoc 1976; 93: 1149-1153.
    • 10 Schutzbank S G, Marchwinski M, Kronman J H, Goldman M, Clark R E. A comparative in vitro study of GK-101 and GK-101E in caries removal J Dent Res 1978; 57: 861-864
    • 11 Habib C M, Kronman J, Goldman M. A chemical evaluation of collagen and hydroxyproline after treatment with GK-101 (N-monochloroglycine). Phar Thera Dent 1975; 2; 209-215.
    • 12 Yip H K, Beeley J A. Studies on the reaction of NaOCI and NMAB with collagen J. Dent Res 1989; 68: 982.
    • 13 Burke F, Lynch E. Chemomechanical caries removal. J Irish Dent Assoc 1995: 41; 10-14
    • 14 Yip H K, Beeley J A, Stevenson A G. The interface between carious and sound dentine - an SEM study. Med Sci Res 1991: 19; 187-188.
    • 15 Burke F M, Lynch E. The effect of chemomechanical caries removal on the bond strength of glass polyalkenoate cement to dentine. J Dent 1994: 22; 283-291.
    • 16 Kidd E A M, Joyston-Bechel S, Beighton D. Microbiological validation of assessments of caries activity during cavity preparation. Caries Res: 27; 402-408.
    • 17. Lynch E, Sheerin A, Silwood C J, Grootveld M C. Detection and determination of protein carbonyl adducts in primary root caries. J Dent Res: 76; 1049.
    • 18 Kleter G A, Damen J J M, Buigus M J, ten Cate J M. Modification of amino acid residues in carious dentine matrix. J Dent Res 1998: 77; 488-495.
    • 19 Watson T F, Kidd E A M. USA: the Caridex caries removal system. Br Dent J 1986: 161; 461-462.
    • 20 Yip H K, Stevenson A G, Beeley J A. An improved reagent for chemomechanical removal of dental caries in permanent and deciduous teeth. An in vitro study J. Dent 1995; 23: 197-204.
    • 21 Yip H K, Stevenson A G, Beeley J A. Chemomechanical removal of dental caries in deciduous teeth: further studies in vitro Br Dent J 1999; 186: 179-182.
    • 22 Bawart O, Moschen I, Graber A, Pfaller K. In vitro study comparing the efficacy of Nmonochloro-D, L-2aminobutyrate (NMAB, GK-101E) and water in caries removal. J Oral Rehabil 1991: 18; 535-536.
    • 23 Yip H K, Beeley J A, Stevenson A G. Mineral content of the dentine remaining after chemomechanical caries removal. Caries Res 1995; 29: 111-117.
    • 24 Ericson D, Simmerman M, Raber H, Götrick B, Bornstein R. Clinical evaluation of efficacy and safety of a new method for chemomechanical removal of caries. Caries Res 1999; 33: 171-177.
    • 25. Moran C, Lynch E, Petersson L, Borshboom P. Comparison of caries removal using CarisolvTM or a conventional slow speed rotary instrument. Caries Res 1999; 33; 313.
    • 26 Banerjee A, Watson T F, Kidd E A M. Carious dentine excavation using CarisolvTM gel: a quantitative autofluorescence assessment using scanning microscopy. Caries Res 1999; 33: 313.
  • No related research data.
  • No similar publications.

Share - Bookmark

Download from

Cite this article