Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Nelson, Andrew J.D.; Thur, Karen E.; Marsden, Charles A.; Cassaday, Helen J. (2012)
Publisher: Cambridge University Press
Journal: The International Journal of Neuropsychopharmacology
Languages: English
Types: Article
Subjects: Core, serotonin, Research Article, latent inhibition, shell, nucleus accumbens
There is good evidence that forebrain serotonergic systems modulate cognitive flexibility. Latent inhibition (LI) is a cross-species phenomenon which manifests as poor conditioning to a stimulus that has previously been experienced without consequence and is widely considered an index of the ability to ignore irrelevant stimuli. While much research has focused on dopaminergic mechanisms underlying LI, there is also considerable evidence of serotonergic modulation. However, the neuroanatomical locus of these effects remains poorly understood. Previous work has identified the nucleus accumbens (NAc) as a key component of the neural circuit underpinning LI and furthermore, this work has shown that the core and shell subregions of the NAc contribute differentially to the expression of LI. To examine the role of the serotonergic input to NAc in LI, we tested animals with 5,7-dihydroxytryptamine (5,7-DHT) lesions to the core and shell subregions on LI assessed under experimental conditions that produce LI in shams and subsequently with weak stimulus pre-exposure designed to prevent the emergence of LI in shams. We found that serotonergic deafferentation of the core disrupted LI whereas 5,7-DHT lesions to the shell produced the opposite effect and potentiated LI.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • Alex KD, Pehek EA (2007). Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacology & Therapeutics 113, 296-320.
    • Asin KE, Wirtshafter D, Kent EW (1980). The effects of electrolytic median raphe lesions on two measures of latent inhibition. Behavioral Neural Biology 28, 409-418.
    • Baruch I, Hemsley DR, Gray JA (1988). Differential performance of acute and chronic schizophrenics in a latent inhibition task. Journal of Nervous and Mental Disorders 176, 598-606.
    • Brigman JL, Mathur P, Harvey-White J, Izquierdo A, et al. (2010). Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice. Cerebral Cortex 20, 1955-63.
    • Brown P, Molliver ME (2000). Dual serotonin (5-HT) projections to the nucleus accumbens core and shell : relation of the 5-HT transporter to amphetamine-induced neurotoxicity. Journal of Neuroscience 20, 1952-9163.
    • Cassaday HJ, Hodges H, Gray JA (1993a). The effects of ritanserin, RU 24969 and 8-OH-DPAT on latent inhibition in the rat. Journal of Psychopharmacology 7, 63-71.
    • Cassaday HJ, Mitchell SN, Williams JH, Gray JA (1993b). 5,7-Dihydroxytryptamine lesions in the fornix-fimbria attenuate latent inhibition. Behavioral and Neural Biology 59, 194-207. [Published erratum appears in Behavioral and Neural Biology 60, 186.]
    • Clarke HF, Dalley JW, Crofts HS, Robbins TW, et al. (2004). Cognitive inflexibility after prefrontal serotonin depletion. Science 304, 878-880.
    • Cools R, Roberts AC, Robbins TW (2008). Sertoninergic regulation of emotional and behavioural control processes. Trends in Cognitive Sciences 12, 31-40.
    • Coutureau E, Blundell PJ, Killcross S (2001). Basolateral amygdala lesions disrupt latent inhibition in rats. Brain Research Bulletin 56, 49-53.
    • Coutureau E, Galani R, Gosselin O, Majchrzak M, et al. (1999). Entorhinal but not hippocampal or subicular lesions disrupt latent inhibition in rats. Neurobiology of Learning and Memory 72, 143-57.
    • Di Matteo V, Di Giovanni G, Di Mascio M, Esposito E (2000). Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin 2C receptors. Brain Research 865, 85-90.
    • Feldon J, Shofel A, Weiner I (1991). Latent inhibition is unaffected by direct dopamine agonists. Pharmacology, Biochemistry and Behavior 38, 309-324.
    • Fletcher PJ (1991). Dopamine receptor blockade in nucleus accumbens or caudate nucleus differentially affects feeding induced by 8-OHDPAT injected into dorsal or median raphe. Brain Research 552, 181-189.
    • Fletcher PJ (1995). Effects of combined or separate 5,7-dihydroxytryptamine lesions of the dorsal and median raphe nuclei on responding maintained by a DRL 20 s schedule of food reinforcement. Brain Research 675, 45-54.
    • Fletcher PJ, Chambers JW, Rizos Z, Chintoh AF (2009). Effects of 5-HT depletion in the frontal cortex or nucleus accumbens on response inhibition measured in the 5- choice serial reaction time test and on a DRL schedule. Behavioral Brain Research 201, 88-98.
    • Fletcher PJ, Korth KM, Chambers JW (1999). Selective destruction of brain serotonin neurons by 5,7- dihydroxytryptamine increases responding for a conditioned reward. Psychopharmacology 147, 291-299.
    • Fletcher PJ, Ming ZH, Higgins GA (1993). Conditioned place preference induced by microinjection of 8-OH-DPAT into the dorsal or median raphe nucleus. Psychopharmacology 113, 31-36.
    • Gal G, Schiller D, Weiner I (2005). Latent inhibition is disrupted by nucleus accumbens shell lesion but is abnormally persistent following entire nucleus accumbens lesion : the neural site controlling the expression and disruption of the stimulus preexposure effect. Behavioral Brain Research 162, 246-255.
    • George DN, Duffaud AM, Pothuizen HH, Haddon JE, et al. (2010). Lesions to the ventral, but not the dorsal, medial prefrontal cortex enhance latent inhibition. European Journal of Neuroscience 31, 1474-1482.
    • Grace AA (1991). Phasic vs. tonic dopamine release and the modulation of dopamine system through responsivity : a hypothesis for the etiology of schizophrenia. Neuroscience 41, 1-24.
    • Gray JA, Feldon J, Rawlins JNP, Hemsley DR, et al. (1991). The neuropsychology of schizophrenia. Behavioral and Brain Sciences 14, 1-20.
    • Gray JA, Kumari V, Lawrence N, Young AMJ (1999). Functions of the dopaminergic innervation of the nucleus accumbens. Psychobiology 27, 225-235.
    • Gray JA, Moran PM, Grigoryan G, Peters S, et al. (1997). Latent inhibition : the nucleus accumbens connection revisited. Behavioral Brain Research 88, 27-35.
    • Gray NS, Pickering AD, Hemsley DR, Dawling S, et al. (1992). Abolition of latent inhibition by a single 5 mg dose of D-amphetamine in man. Psychopharmacology 107, 425-430.
    • Honey RC, Good M (1993). Hippocampal lesions abolish the contextual specificity of latent inhibition and conditioning. Behavioral Neuroscience 107, 23-33.
    • Jiang LH, Ashby CRJ, Kasser RJ, Wang RY (1990). The effect of intraventricular administration of the 5-HT3 receptor agonist 2-methylserotonin on the release of dopamine in the nucleus accumbens : an in vivo chronocoulometric study. Brain Research 513, 156x160.
    • Joseph MH, Peters SL, Moran PM, Grigoryan GA, et al. (2000). Modulation of latent inhibition in the rat by altered dopamine transmission in the nucleus accumbens at the time of conditioning. Neuroscience 101, 921-930.
    • Kehagia AA, Murray GK, Robbins TW (2010). Learning and cognitive flexibility : frontostriatal function and monoaminergic modulation. Current Opinion in Neurobiology 20, 199-204.
    • Kumari V, Cotter PA, Mulligan OF, Checkley SA, et al. (1999). Effects of D-amphetamine and haloperidol on latent inhibition in healthy male volunteers. Journal of Psychopharmacology 13, 398-405.
    • Lorden JF, Rickert EJ, Berry DW (1983). Forebrain monoamines and associative learning : I. Latent inhibition and conditioned inhibition. Behavioral Brain Research 9, 181-199.
    • Loskutova LV (1998). The place of the action of the serotoninergic system in the two-stage process of formation of latent inhibition in rats. Zhurnal vysshe˘ı nervno˘ı deiatelnosti imeni I P Pavlova 48, 348-352.
    • Loskutova LV (2001). The effect of a serotoninergic substrate of the nucleus accumbens on latent inhibition. Neuroscience and Behavioral Physiology 31, 15-20.
    • Lubow RE, Moore AU (1959). Latent inhibition : the effect of non-reinforced preexposure to the conditional stimulus. Journal of Comparative and Physiological Psychology 52, 415-419.
    • Lucki I, Harvey JA (1979). Increased sensitivity to d-and l-amphetamine action after midbrain raphe lesions as measured by locomotor activity. Neuropharmacology 18, 243-249.
    • Ludwig V, Schwarting RKW (2007). Neurochemical and behavioral consequences of striatal injection of 5,7- dihydroxytryptamine. Journal of Neuroscience Methods 162, 108-18.
    • Lyness WH, Moore KE (1981). Destruction of 5- hydroxytryptaminergic neurons and the dynamics of dopamine in nucleus accumbens septi and other forebrain regions of the rat. Neuropharmacology 20, 327-34.
    • Mamounas LA, Mullen CA, O'Hearn E, Molliver ME (1991). Dual serotonergic projections to forebrain in the rat : morphologically distinct 5-HT axon terminals exhibit differential vulnerability to neurotoxic amphetamine derivatives. Journal of Comparative Neurology 314, 558-586.
    • Mohr D, von Ameln-Mayerhofer A, Fendt M (2009). 5,7- dihydroxytryptamine injections into the prefrontal cortex and nucleus accumbens differently affect prepulse inhibition and baseline startle magnitude in rats. Behavioural Brain Research 202, 58-63.
    • Nelson AJD, Thur KE, Marsden CA, Cassaday HJ (2010). Catecholaminergic depletion within the prelimbic medial prefrontal cortex enhances latent inhibition. Neuroscience 170, 99-106.
    • Nelson AJD, Thur KE, Marsden CA, Cassaday HJ (2011a). Dopamine in nucleus accumbens : salience modulation in latent inhibition and overshadowing. Journal of Psychopharmacology. Published online : 31 January 2011. doi :10.1037/a0021114.
    • Nelson AJD, Thur KE, Horsley RR, Spicer C, et al. (2011b). Recued dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition. Pharmacology, Biochemistry & Behavior 98, 1-7.
    • Norman C, Cassaday HJ (2004). Disruption of latent inhibition to a contextual stimulus with systemic amphetamine. Neurobiology of Learning and Memory 82, 61-4.
    • Parkinson JA, Dalley JW, Cardinal RN, Bamford A, et al. (2002). Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behavior : implications for mesoaccumbens dopamine function. Behavioural Brain Research 137, 149-63.
    • Parsons LH, Justice JB (1993). Perfusate serotonin increases extracellular dopamine in the nucleus accumbens as measured by in vivo microdialysis. Brain Research 606, 195-199.
    • Paxinos G, Watson C (2005). The Rat Brain in Stereotaxic Coordinates, 5th edn. San Diego, CA : Academic Press.
    • Pothuizen HH, Jongen-Reˆlo AL, Feldon J, Yee BK (2006). Latent inhibition of conditioned taste aversion is not disrupted, but can be enhanced, by selective nucleus accumbens shell lesions in rats. Neuroscience 137, 1119-30.
    • Schiller D, Weiner I (2004). Lesions to the basolateral amygdala and the orbitofrontal cortex but not to the medial prefrontal cortex produce an abnormally persistent latent inhibition. Neuroscience 128, 215-22.
    • Sellings LHL, Baharnouri G, McQuade LE, Clarke PBS (2008). Rewarding and aversive effects of nicotine are segregated within the nucleus accumbens. European Journal of Neuroscience 28, 342-352.
    • Shadach E, Gaisler I, Schiller D, Weiner I (2000). The latent inhibition model dissociates between clozapine, haloperidol, and ritanserin. Neuropsychopharmacology 23, 151-61.
    • Solomon P, Nichols GL, Kiernan JMI, Kamer RS, et al. (1980). Differential effects of lesions in medial and dorsal raphe of the rat : latent inhibition and septo-hippocampal serotonin levels. Journal of Comparative and Physiological Psychology 94, 145-154.
    • Solomon PR, Crider A, Winkelman JW, Turi A, et al. (1981). Disrupted latent inhibition in the rat with chronic amphetamine or haloperidol-induced supersensitivity : relationship to schizophrenic attention disorder. Biological Psychiatry 16, 519-537.
    • Solomon PR, Kiney CA, Scott DR (1978). Disruption of latent inhibition following systemic administration of parachlorphenylalanine (PCPA). Physiology and Behavior 20, 265-271.
    • Tai C-T, Cassaday HJ, Feldon J, Rawlins JNP (1995). Both electrolytic and excitotoxic lesions of nucleus accumbens disrupt latent inhibition of learning in rats. Neurobiology of Learning and Memory 64, 36-48.
    • Van Bockstaele EJ, Biswas A, Pickel VM (1993). Topography of serotonin neurons in the dorsal raphe nucleus that send axon collaterals to the rat prefrontal cortex and nucleus accumbens. Brain Research 624, 188-198.
    • Van Bockstaele EJ, Pickel VM (1993). Ultrastructure of serotonin-immunoreactive terminals in the core and shell of the rat nucleus accumbens : cellular substrates for interactions with catecholamine afferents. Journal of Comparative Neurology 334, 603-617.
    • van Dongen YC, Deniau J-M, Pennartz CMA, Galis-de Graaf Y, et al. (2005). Anatomical evidence for direct connections between the shell and core subregions of the rat nucleus accumbens. Neuroscience 136, 1049-1071.
    • Warburton EC, Mitchell SN, Joseph MH (1996). Calcium dependent dopamine release in rat nucleus accumbens following amphetamine challenge : implications for the disruption of latent inhibition. Behavioural Pharmacology 7, 119-129.
    • Weiner I (1990). Neural substrates of latent inhibition : the switching model. Psychological Bulletin 108, 442-461.
    • Weiner I (2003). The ' two-headed' latent inhibition model of schizophrenia : modelling positive and negative symptoms and their treatment. Psychopharmacology 169, 257-297.
    • Weiner I, Arad M (2009). Using the pharmacology of latent inhibition to model domains of pathology in schizophrenia and their treatment. Behavioural Brain Research 204, 369-386.
    • Weiner I, Feldon J (1987). Facilitation of latent inhibition by haloperidol in rats. Psychopharmacology 91, 248-253.
    • Weiner I, Gal G, Rawlins JNP, Feldon J (1996). Differential involvement of the shell and core subterritories of the nucleus in latent inhibition and amphetamine-induced activity. Behavioural Brain Research 81, 123-133.
    • Weiner I, Lubow RE, Feldon J (1984). Abolition of the expression but not the acquisition of latent inhibition by chronic amphetamine in rats. Psychopharmacology 83, 194-199.
    • Weiner I, Tarrasch R, Feldon J (1995). Basolateral amygdala lesions do not disrupt latent inhibition. Behavioural Brain Research 72, 73-81.
    • Williams H, Wellman HE, Geaney D, Feldon J, et al. (1997). Haloperidol enhances latent inhibition in visual tasks in healthy people. Psychopharmacology 133, 262-268.
    • Wogar MA, Bradshaw CM, Szabadi E (1991). Evidence for an involvement of 5-hydroxytryptaminergic neurones in the maintenance of operant behaviour by positive reinforcement. Psychopharmacology 105, 119-124.
    • Yan Q-S, Yan S-E (2001). Activation of 5-HT1B/1D receptors in the mesolimbic dopamine system increases dopamine release from the nucleus accumbens : a microdialysis study. European Journal of Pharmacology 418, 55x64.
    • Yoshimoto K, McBride W (1992). Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat. Neurochemical Research 17, 401-407.
    • Young AM, Moran PM, Joseph MH (2005). The role of dopamine in conditioning and latent inhibition : what, when, where and how? Neuroscience and Biobehavioral Reviews 29, 963-76.
    • Zahm DS (1999). Functional-anatomical implications of the nucleus accumbens core and shell subterritories. Annals of the New York Academy of Sciences 877, 113-128.
    • Zhou FC, Tao-Cheng JH, Segu L, Patel T, Wang Y (1998). Serotonin transporters are located on the axons beyond the synaptic junctions : anatomical and functional evidence. Brain Research 805, 241-254.
  • No related research data.
  • Discovered through pilot similarity algorithms. Send us your feedback.

    Title Year Similarity

    Étude d'une nouvelle classe d'inhibiteurs de la rétrotranscriptase et de l'intégrase du virus de l'immunodéficience humaine de type-1 (VIH-1).


    5,7-Dihydroxytryptamine (5,7-DHT)による中枢性セロトニン涸渇と耐糖能障害に関する検討


    Effects of 5,7-dihydroxytriptamine (5,7-DHT) on circadian locomotor activity of the blow fly, Calliphora vicina




    Modulation of defensive reflex conditioning in snails by serotonin


    Modulation of defensive reflex conditioning in snails by serotonin


    Serotonin Modulates the Suppressive Effects of Corticosterone on Proliferating Progenitor Cells in the Dentate Gyrus of the Hippocampus in the Adult Rat




    Indoleamine-accumulating cell death and endogenous glial cell reaction induced by 5,7-dihydroxytryptamine in the cat retina.


    Pharmacological depletion of serotonin in the basolateral amygdala complex reduces anxiety and disrupts fear conditioning


    Effects of 5,7-dihydroxytryptamine on an identified 5-hydroxytryptamine-containing neurone in the central nervous sytem of the snail Helix pomatia.


    Effect of serotonin axon injury on the somatostatinergic system in rat frontoparietal cortex


    Ethanol consumption in the Sprague-Dawley rat increases sensitivity of the dorsal raphe nucleus to 5,7-dihydroxytryptamine


    CaMKIIα Knockdown Decreases Anxiety in the Open Field and Low Serotonin-Induced Upregulation of GluA1 in the Basolateral Amygdala


    Chronic Alterations in Serotonin Function: Dynamic Neurochemical Properties in Agonistic Behavior of the Crayfish, Orconectes rusticus


    Modulation of defensive reflex conditioning in snails by serotonin


    Neonatal 5,7-DHT Lesions Cause Sex-Specific Changes in Mouse Cortical Morphogenesis


    Medial prefrontal serotonin in the rat is involved in goal-directed behaviour when affect guides decision making


Share - Bookmark

Funded by projects

  • WT
  • WT | The neuropharmacological sub...

Cite this article