Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Banks, Shel C; Thomas, Megan R; Gordon, Morris; Wallace, Chris; Akobeng, Anthony (2016)
Publisher: John Wiley and Sons
Languages: English
Types: Article
Subjects: A300
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:\ud \ud 1.To assess the effectiveness and safety of prophylactic probiotics for preventing or reducing colic in infants.\ud \ud 2.To identify the likely effective probiotic strains for such an approach.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • from inception onwards. 1. Cochrane Central Register of Controlled Trials
    • Learning Problems Specialised Register. 2. MEDLINE Ovid (from 1946). 3. MEDLINE In-Process & Other Non-Indexed Citations
    • OvidSP (current issue). 4. MEDLINE Epub Ahead of Print Ovid (current issue). 5. Embase Ovid (from 1980). 6. CINAHL EBSCO (Cumulative Index to Nursing and
    • Allied Health Literature; from 1937). 7. PsycINFO Ovid (from 1967). 8. Science Citation Index Expanded Web of Science (SCI;
    • from 1970). 9. Social Sciences Citation Index Web of Science (SSCI; from
    • 10. Conference Proceedings Citation Index - Science Web of
    • Science (CPCI-S; from 1990).
    • 11. Conference Proceedings Citation Index - Social Science &
    • Humanities Web of Science (CPCI-SS&H; from 1990).
    • 12. LILACS (Latin American and Caribbean Health Science
    • 13. Cochrane Database of Systematic Reviews (CDSR; current
    • 14. Database of Abstracts of Reviews of Effects (DARE; current
    • 15. Epistemonikos (limited to systematic reviews;
    • 16. WorldCat (limited to theses; www.worldcat.org; all
    • 17. US National Institutes of Health Ongoing Trials Register
    • 18. World Health Organization International Clinical Trials
    • 2, which uses the sensitivity maximising version of the Cochrane
    • Reviews of Interventions (Lefebvre 2011). We will adapt this strat-
    • Baldassarre 2010 Baldassarre ME, Laforgia N, Fanelli M, Laneve A, Grosso R, Lifschitz C. Lactobacillus GG improves recovery in infants with blood in the stools and presumptive allergic colitis compared with extensively hydrolyzed formula alone. The Journal of Pediatrics 2010;156(3):397-401. [DOI: 10.1016/j.jpeds.2009.09.012; PUBMED: 19880141]
    • Braeggar 2011 Braegger C, Chmielewska A, Decsi T, Kolacek S, Mihatsch W, Moreno L, et al. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by the ESPGHAN committee on nutrition. Journal of Pediatric Gastroenterology and Nutrition 2011;52 (2):238-50. [DOI: 10.1097/MPG.0b013e3181fb9e80; PUBMED: 21150647]
    • Campbell 1989 Campbell JP. Dietary treatment of infant colic: a doubleblind study. Journal of the Royal College of General Practitioners 1989;39(318):11-4. [PUBMED: 2553940]
    • Campbell 2000 Campbell M, Grimshaw J, Steen N. Sample size calculations for cluster randomised trials. Changing Professional Practice in Europe Group (EU BIOMED II Concerted Action). Journal of Health Services Research & Policy 2000;5(1):12-6. [PUBMED: 10787581]
    • Canabar 2001 Kanabar D, Randhawa M, Clayton P. Improvement of symptoms in infant colic following reduction of lactose load with lactase. Journal of Human Nutrition and Dietetics 2001;14(5):359-63. [PUBMED: 11906576]
    • Clifford 2002 Clifford TJ, Campbell MK, Speechley KN, Gorodzinsky F. Infant colic: empirical evidence of the absence of an association with source of early infant nutrition. Archives
    • of Pediatrics & Adolescent Medicine 2002;156(11):1123-8.
    • [PUBMED: 12413341]
    • de Weerth 2013 de Weerth C, Fuentes S, Puylaert P, de Vos WM. Intestinal microbiota of infants with colic: development and specific signatures. Pediatrics 2013;131(2):e550-8. [DOI: 10.1542/peds.2012-1449]
    • Deeks 2011 Deeks JJ, Higgins JPT, Altman DG. Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
    • Deshpande 2010 Deshpande G, Rao S, Patole S, Bulsara M. Updated metaanalysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics 2010;125(5):921-30. [DOI: 10.1542/peds.2009-1301]
    • Deshpande 2011 Deshpande GC, Rao SC, Keil AD, Patole SK. Evidencebased guidelines for use of probiotics in preterm neonates. BMC Medicine 2011;9:92. [DOI: 10.1186/ 1741-7015-9-92; PMC3163616]
    • Dupont 2010 Dupont C, Rivero M, Grillon C, Belaroussi N, Kalindjian A, Marin V. Alpha-lactalbumin-enriched and probioticsupplemented infant formula in infants with colic: growth and gastrointestinal tolerance. European Journal of Clinical Nutrition 2010;64(7):765-7. [DOI: 10.1038/ ejcn.2010.81; PUBMED: 20517331]
    • Estep 2000 Estep DC, Kulczycki A Jr. Treatment of infant colic with amino acid-based infant formula: a preliminary study. Acta Paediatrica 2000;89(1):22-7. [PUBMED: 10677052]
    • Freedman 2009 Freedman SB, Al-Harthy N, Thull-Freedman J. The crying infant: diagnostic testing and frequency of serious underlying disease. Pediatrics 2009;123(3):841-8. [DOI: 10.1542/peds.2008-0113; PUBMED: 19255012]
    • Garrison 2000 Garrison MM, Christakis DA. A systematic review of treatments for infant colic. Pediatrics 2000;106(1 Pt 2): 184-90. [PUBMED: 10888690]
    • Gordon 2012 Gordon M, Harper V, Thomas AG, Akobeng A. Bowel preparation for paediatric colonoscopy. Cochrane Database of Systematic Reviews 2012, Issue 7. [DOI: 10.1002/ 14651858.CD009976]
    • Grönlund 1999 Grönlund MM, Lehtonen OP, Eerola E, Kero P. Fecal microflora in healthy infants born by different methods of delivery: permanent changes in intestinal flora after cesarean
    • Hill 2005 Hill DJ, Roy N, Heine RG, Hosking CS, Francis DE, Brown J, et al. Effect of a low-allergen maternal diet on colic among breastfed infants: a randomized, controlled trial. Pediatrics 2005;116(5):e709-15. [DOI: 10.1542/ peds.2005-0147; PUBMED: 16263986]
    • Houghteling 2015 Houghteling PD, Walker WA. Why is initial bacterial colonization of the intestine important to infants' and children's health?. Journal of Paediatric Gastroenterology and Nutrition 2015;60(3):294-307. [DOI: 10.1097/ MPG.0000000000000597; PMC4340742; PUBMED: 25313849]
    • Hyams 1989 Hyams JS, Geertsma MA, Etienne NL, Treem WR. Colonic hydrogen production in infants with colic. The Journal of Pediatrics 1989;115(4):592-4. [PUBMED: 2795353]
    • Hyman 2006 Hyman PE, Milla PJ, Benninga MA, Davidson GP, Fleisher DF, Taminiau J. Childhood functional gastrointestinal disorders: neonate/toddler. Gastreoenterology 2006;130 (5):1519-26. [DOI: 10.1053/j.gastro.2005.11.065; PUBMED: 16678565]
    • Iacono 1991 Iacono G, Carroccio A, Montalto G, Cavataio F, Bragion E, Lorello D, et al. Severe infantile colic and food intolerance: a long-term prospective study. Journal of Pediatric Gastroenterology and Nutrition 1991;12(3):332-5. [PUBMED: 2072224]
    • Iacono 2005 Iacono G, Merolla R, D'Amico D, Bonci E, Cavataio F, Di Prima L, et al. Gastrointestinal symptoms in infancy: a population-based prospective study. Digestive and Liver Disease 2005;37(6):432-8. [DOI: 10.1016/ j.dld.2005.01.009; PUBMED: 15893282]
    • Iacovou 2012 Iacovou M, Ralston RA, Muir J, Walker KZ, Truby H. Dietary management of infantile colic: a systematic review. Maternal and Child Health Journal 2012;16(6): 1319-31. [DOI: 10.1007/s10995-011-0842-5; PUBMED: 21710185]
    • Indrio 2014 Indrio F, Di Mauro A, Riezzo G, Civardi E, Intini C, Corvaglia L, et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatrics 2014;168(3):228-33. [DOI: 10.1001/ jamapediatrics.2013.4367; PUBMED: 24424513]
    • Infante 2011 Infante D, Segarra O, Luyer BL. Dietary treatment of colic caused by excess gas in infants: biochemical evidence. World Journal of Gastroenterology 2011;17(16):2104-8. [DOI: 10.3748/wjg.v17.i16.2104; PMC3084395; PUBMED: 21547129]
    • Jakobsson 1983 Jakobsson I, Lindberg T. Cow's milk proteins cause infantile colic in breast-fed infants: a double-blind crossover study. Pediatrics 1983;71(2):268-71.
    • Jakobsson 2000 Jakobsson I, Lothe L, Ley D, Borschel MW. Effectiveness of casein hydrolysate feedings in infants with colic. Acta Paediatrica 2000;89(1):18-21. [PUBMED: 10677051]
    • Kukkonen 2008 Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, et al. Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebocontrolled trial. Pediatrics 2008;122(1):8-12. [DOI: 10.1542/peds.2007-1192; PUBMED: 18595980]
    • Landgren 2011 Landgren K, Hallström I. Parents' experience of living with a baby with infantile colic - a phenomenological hermeneutic study. Scandinavian Journal of Caring Sciences 2011;25 (2):317-24. [DOI: 10.1111/j.1471-6712.2010.00829.x; PUBMED: 20723153]
    • Lederberg 2001 Lederberg J, McCray AT. 'Ome Sweet 'Omics-a genealogical treasury of words. www.the-scientist.com/? articles.view/articleNo/13313/title/-Ome-Sweet--Omics--- A-Genealogical-Treasury-of-Words/ (accessed 7 December 2016).
    • Lefebvre 2011 Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
    • Lindberg 1999 Lindberg T. Infantile colic and small intestinal function: a nutritional problem?. Acta Paediatrica 1999;88(430): 58-60.
    • Lothe 1982 Lothe L, Lindberg T, Jakobsson I. Cow's milk formula as a cause of infantile colic: a double-blind study. Pediatrics 1982;70(1):7-10. [PUBMED: 7088636]
    • Lothe 1989 Lothe L, Lindberg T. Cow's milk whey protein elicits symptoms of infantile colic in colicky formula-fed infants: a double-blind crossover study. Pediatrics 1989;83(2):262-6. [PUBMED: 2913556]
    • Lucas 1998 Lucas A, St James-Roberts I. Crying, fussing and colic behaviour in breast- and bottle-fed infants. Early Human Development 1998;53(1):9-18. [PUBMED: 10193923]
    • Lucassen 2000 Lucassen PL, Assendelft WJ, Gubbels JW, Van Eijk JT, Douwes AC. Infantile colic: crying time reduction with a whey hydrolysate: a double-blind, randomized, placebo-controlled trial. Pediatrics 2000;106(6):1349-54. [PUBMED: 11099588]
    • Lucassen 2001 Lucassen PL, Assendelft WJ, van Eijk JT, Gubbels JW, Douwes AC, van Geldrop WJ. Systematic review of the occurrence of infantile colic in the community. Archives of Disease in Childhood 2001;84(5):398-403. [DOI: 10.1136/ adc.84.5.398]
    • Merras-Salmio 2013 Merras-Salmio L, Pelkonen AS, Kolho KL, Kuitunen M, Mäkelä MJ. Cow's milk-associated gastronintestinal symptoms evaluated using the double-blind, placebocontrolled food challenge. Journal of Paediatric Gastroenterology and Nutrition 2013;57(3):281-6. [DOI: 10.1097/MPG.0b013e3182993fe0; PUBMED: 23974059]
    • Milidou 2012 Milidou I, Henriksen TB, Jensen MS, Olsen J, Søndergaard C. Nicotine replacement therapy during pregnancy and infantile colic in the offspring. Pediatrics 2012;129(3): e652-8. [DOI: 10.1542/peds.2011-2281]
    • Miller 1990 Miller JJ, Brand JC, McVeagh P. Breath hydrogen excretion in infants with colic. Archives of Disease in Childhood 1990; 65(2):248. [PMC1792219]
    • Moher 2009 Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Annals of Internal Medicine 2009;151(4):264-9. [PUBMED: 19622511]
    • Moore 1988 Moore DJ, Robb TA, Davidson GP. Breath hydrogen response to milk containing lactose in colicky and noncolicky infants. The Journal of Pediatrics 1988;113(6): 979-84. [PUBMED: 3193321]
    • Mostafa 2008 Mostafa R. Rome III: The functional gastrointestinal disorders, third edition, 2006. World Journal of Gastroenterology 2008;14(13):2124-25. [DOI: 10.3748/ wjg.14.2124; PMC2701540]
    • Naidoo 2011 Naidoo K, Gordon M, Fagbemi AO, Thomas AG, Akobeng AK. Probiotics for maintenance of remission in ulcerative colitis. Cochrane Database of Systematic Reviews 2011, Issue 12. [DOI: 10.1002/14651858.CD007443.pub2]
    • NHS England Breastfeeding Initiation Q1 2015/16 NHS England Statistical Release Breastfeeding Initiation & Breastfeeding Prevalence 6-8 weeks Quarter 1 2015/16. https://www.england.nhs.uk/statistics/wp-content/uploads/ sites/2/2014/03/Breastfeeding-1516Q11.pdf September 2015:4.
    • NHS Maternity Statistics, England 2014-15 Hospital Episode Statistics NHS Maternity Statistics - England, 2014-15. Health and Social Care Information Centre http://content.digital.nhs.uk/catalogue/PUB19127/ nhs-mate-eng-2014-15-summ-repo-rep.pdf Jan 2016:12.
    • Oozeer 2013 Oozeer R, van Limpt K, Ludwig T, Ben Amor K, Martin R, Wind RD, et al. Intestinal microbiology in early
    • Clinical Nutrition 2013;98(2):561S-71S. [DOI: 10.3945/
    • ajcn.112.038893]
    • Oxman 1992 Oxman AD, Guyatt GH. A consumer's guide to subgroup analyses. Annals of Internal Medicine 1992;116(1):78-84. [PUBMED: 1530753]
    • Perry 2011 Perry R, Hunt K, Ernst E. Nutritional supplements and other complementary medicines for infantile colic: a systematic review. Pediatrics 2011;127(4):720-33. [DOI: 10.1542/peds.2010-2098; PUBMED: 21444591]
    • Pitkin 1999 Pitkin RM, Branagan MA, Burmeister LF. Accuracy of data in abstracts of published research articles. JAMA 1999;281 (12):1110-1. [PUBMED: 10188662]
    • Praveen 2014 Praveen V, Praveen S, Deshpande G, Patole SK. Oral probiotics for infantile colic. Cochrane Database of Systematic Reviews 2014, Issue 3. [DOI: 10.1002/ 14651858.CD010986]
    • Pärtty 2013 Pärtty A, Luoto R, Kalliomäki M, Salminen S, Isolauri E. Effects of early prebiotic and probiotic supplementation on development of gut microbiota and fussing and crying in preterm infants: a randomized, double-blind, placebo-controlled trial. The Journal of Pediatrics 2013; 163(5):1272-7.e2. [DOI: 10.1016/j.jpeds.2013.05.035; PUBMED: 23915796]
    • Reijneveld 2001 Reijneveld SA, Brugman E, Hirasing RA. Excessive infant crying: the impact of varying definitions. Pediatrics 2001; 108(4):893-7. [PUBMED: 11581441]
    • RevMan 2014 [Computer program] Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager 5 (RevMan 5). Version 5.3. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
    • Rijkers 2011 Rijkers GT, de Vos WM, Brummer RJ, Morelli L, Corthier G, Marteau P. Health benefits and health claims of probiotics: bridging science and marketing. British Journal of Nutrition 2011;106(9):1291-6. [DOI: 10.1017/ S000711451100287X; PUBMED: 21861940]
    • Roberfroid 2007 Roberfroid M. Prebiotics: the concept revisited. Journal of Nutrition 2007;137(3 Suppl 2):830S-7S. [PUBMED: 17311983]
    • Romanello 2013 Romanello S, Spiri D, Marcuzzi E, Zanin A, Boizeau P, Riviere S, et al. Association between childhood migraine and history of infantile colic. JAMA 2013;309(15): 1607-12. [DOI: 10.1001/jama.2013.747; PUBMED: 23592105]
    • Rosen 2007 Rosen LD, Bukutu C, Le C, Shamseer L, Vohra S. Complementary, holistic, and integrative medicine: colic. Pediatrics in Review 2007;28(10):381-5. [DOI: 10.1542/ pir.28-10-381]
    • Saps 2011 Saps M, Lu P, Bonilla S. Cow's-milk allergy is a risk factor for the development of FGIDs in children. Journal of Paediatric Gastroenerology and Nutrition 2011;52(2):166-9. [DOI: 10.1097/MPG.0b013e3181e85b55; PUBMED: 20975580]
    • Savino 2001 Savino F, Cresi F, Silvestro L, Oggero R. Use of an amino-acid formula in the treatment of colicky breastfed infants. Acta Paediatrica 2001;90(3):359-60. [PUBMED: 11332183]
    • Savino 2005 Savino F, Castagno E, Bretto R, Brondello C, Palumeri E, Oggero R. A prospective 10-year study on children who had severe infantile colic. Acta Paediatrica Supplement 2005; 94(449):129-32. [DOI: 10.1080/08035320510043691; PUBMED: 16214780]
    • Savino 2006 Savino F, Palumeri E, Castagno E, Cresi F, Dalmasso P, Cavallo F, et al. Reduction of crying episodes owing to infantile colic: a randomized controlled study on the efficacy of a new infant formula. European Journal of Clinical Nutrition 2006;60(11):1304-10. [DOI: 10.1038/ sj.ejcn.1602457; PUBMED: 16736065]
    • Savino 2007a Savino F. Focus on infantile colic. Acta Paediatrica 2007;96 (9):1259-64. [DOI: 10.1111/j.1651-2227.2007.00428.x; PUBMED: 17718777]
    • Savino 2007b Savino F, Pelle E, Palumeri E, Oggero R, Miniero R. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics 2007;119(1):e124-30. [DOI: 10.1542/peds.2006-1222]
    • Savino 2010a Savino F, Tarasco V. New treatments for infant colic. Current Opinion in Pediatrics 2010;22(6):791-7. [DOI: 10.1097/MOP.0b013e32833fac24; PUBMED: 20859207]
    • Savino 2010b Savino F, Cordisco L, Tarasco V, Palumeri E, Calabrese R, Oggero R, et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebocontrolled trial. Pediatrics 2010;126(3):e526-33. [DOI: 10.1542/peds.2010-0433; PUBMED: 20713478]
    • Savino 2012 Savino F, Tarasco V, Lingua C, Moja L, Ricceri F. Painrelieving agents for infant colic. Cochrane Database of Systematic Reviews 2012, Issue 7. [DOI: 10.1002/ 14651858.CD009999]
    • Savino 2013a Savino F, Ceratto S, Opramolla A, Locatelli E, Tarasco V, Amaretti A, et al. Coliforms and infant colic: fish analysis of fecal samples of breastfed and formula fed infants. Journal of Paediatric Gastroenterology and Nutrition 2013;56(2):472.
    • Savino 2013b Savino F, Juncker A, Opramolla A, Tarasco V, Ceratto S, Bonde I, et al. Metagenomic analysis of fecal samples from healthy and colicky infants. Journal of Paediatric Gastroenterology and Nutrition 2013;56(2):154.
    • Savino 2014 Savino F, Tarasco V, Sorrenti M, Lingua C, Moja L, Gordon M, et al. Dietary modifications for infantile colic. Cochrane Database of Systematic Reviews 2014, Issue 3. [DOI: 10.1002/14651858.CD011029]
    • Schach 2002 Schach B, Haight M. Colic and food allergy in the breastfed infant: is it possible for an exclusively breastfed infant to suffer from food allergy?. Journal of Human Lactation 2002; 18(1):50-2. [DOI: 10.1177/089033440201800108]
    • Shannon 1921 Shannon WR. Colic in breast-fed infants as a result of sensitization to foods in the mother's diet. Archives Paediatrica 1921;38:756-61.
    • Sterne 2011 Sterne JAC, Egger M, Moher D. Chapter 10: Addressing reporting biases. In: Higgins JP, Green S, editor (s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
    • Sung 2012 Sung V, Hiscock H, Tang M, Mensah F, Heine RG, Stock A, et al. Probiotics to improve outcomes of colic in the community: protocol for the Baby Biotics randomised controlled trial. BMC Pediatrics 2012;12:135. [DOI:
    • Szajewska 2013 Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebocontrolled trial. The Journal of Pediatrics 2013;162(2): 257-62. [DOI: 10.1016/j.jpeds.2012.08.004; PUBMED: 22981952]
    • Thomas 2010 Thomas DW, Greer FR, American Academy of Pediatrics Committee on Nutrition, American Academy of Pediatrics Section on Gastroenterology, Hepatology, Nutrition. Probiotics and prebiotics in pediatrics. Pediatrics 2010;126 (6):1217-31. [DOI: 10.1542/peds.2010-2548; PUBMED: 21115585]
    • Walter 2000 Walter SD. Choice of effect measure for epidemiological data. Journal of Clinical Epidemiology 2000;53(9):931-9. [PUBMED: 11004419]
    • Wessel 1954 Wessel MA, Cobb JC, Jackson EB, Harris GS Jr, Detwiler AC. Paroxysmal fussing in infancy, sometimes called colic. Pediatrics 1954;14(5):421-35. [PUBMED: 13214956]
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article