LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Al-Daghri, Nasser M.; Al-Attas, Omar S.; Al-Rubeaan, Khalid; Mohieldin, Mehad; Al-Katari, Mohammad; Jones, Alan F.; Kumar, Sudhesh (2007)
Publisher: BioMed Central Ltd.
Languages: English
Types: Article
Subjects: R1
Background: Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in prediabetic, (IFG and IGT), type 2 diabetic and normoglycaemic Saudis.\ud Methods: 308 adult Saudis (healthy controls n = 80; pre-diabetes n = 86; Type 2 diabetes n = 142) participated. Anthropometric parameters were measured and fasting blood samples taken. Serum insulin was analysed, using a solid phase enzyme amplified sensitivity immunoassay and also leptin concentrations, using radio-immunoassay. The remaining blood parameters were determined using\ud standard laboratory procedures.\ud Results: Leptin levels of diabetic and pre-diabetic men were higher than in normoglycaemic men (12.4 [3.2–72] vs 3.9 [0.8–20.0] ng/mL, (median [interquartile range], p = 0.0001). In females, leptin levels were significantly higher in pre-diabetic subjects (14.09 [2.8–44.4] ng/mL) than in normoglycaemic subjects (10.2 [0.25–34.8] ng/mL) (p = 0.046). After adjustment for BMI and\ud gender, hip circumference was associated with log leptin (p = 0.006 with R2 = 0.086) among all subjects.\ud Conclusion: Leptin is associated with measures of adiposity, hip circumference in particular, in the\ud non-diabetic state among Saudi subjects. The higher leptin level among diabetics and pre-diabetics is not related to differences in anthropometric measures of obesity.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • al-Nuaim AR, al-Rubeaan K, al-Mazrou Y, al-Attas O, al-Daghari N, Khoja T: High prevalence of overweight and obesity in Saudi Arabia. Int J Obes Relat Metab Disord 1996, 20(11):547-552.
    • al-Nuaim AR, al-Rubeaan K, al-Mazrou Y, al-Attas O, al-Daghari N: Prevalence of hypercholesterolemia in Saudi Arabia, epidemiological study. Int J Cardiol 1996, 54(1):41-49.
    • al-Shammari SA, Ali M, al-Shammari A, al-Maatouq M, Tennier A, Armstrong K: Blood lipid concentrations and other cardiovascular risk factors among Saudis. Fam Pract 1994, 11(2):153-158.
    • Al-Dawood KM: Pattern of smoking among parents of schoolboys. Saudi Med J 2000, 21(8):735-739.
    • Al-Nozha MM, Arafah MR, Al-Mazrou YY, AL-Maatouq MA, Khan NB, Khalil MZ, Al-Khadra AH, Al-Marzouki K, Abdullah MA, Al-Harthi SS, Al-Shahid MS, Nouh MS, Al-Mobeireek A: Coronary Artery Disease in Saudi Arabia. Saudi Med J 2004, 25(9):1165-1171.
    • Al-Turki YA: Overview of chronic diseases in the Kingdom of Saudi Arabia. Saudi Med J 2000, 21(5):499-500.
    • Al-Nuaim AR: Prevalence of glucose intolerance in urban and rural communities in Saudi Arabia. Diabet Med 1997, 14(7):595-602.
    • Baron AD: Impaired glucose tolerance as a disease. Am J Cardiol 2001, 88(6A):16H-19H.
    • 9. Lowe LP, Liu K, Greenland P, Metzger BE, Dyer AR, Stamler J: Diabetes, asymptomatic hyperglycemia, and 22-year mortality in black and white men. The Chicago Heart Association Detection Project in Industry Study. Diabetes Care 1997, 20(2):163-169.
    • 10. Jackson CA, Yudkin JS, Forrest RD: A comparison of the relationships of the glucose tolerance test and the glycated haemoglobin assay with diabetic vascular disease in the community. The Islington Diabetes Survey. Diabetes Res Clin Pract 1992, 17(2):111-123.
    • 11. [No authors listed]: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes care 1997, 20(7):1183-1197.
    • 12. Meigs JB, Muller DC, Nathan DM, Blake DR, Andres R, Baltimore Longitudinal Study of Aging: The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal study of aging. Diabetes 2003, 52(6):1475-1484.
    • 13. Kannel WB, McGee DL: Diabetes and cardiovascular disease: The Framingham Study. JAMA 1979, 241(19):2035-2038.
    • 14. Gu K, Cowie CC, Harris MI: Mortality in adults with and without diabetes in a national cohort of the US population, 1971- 1993. Diabetes Care 1998, 21(7):1138-1145.
    • 15. Woodward M, Zhang X, Barzi F, Pan W, Ueshima H, Rodgers A, MacMahon S, Asia Pacific Cohort Studies Collaboration: The effects of diabetes on the risks of major cardiovascular diseases and death in the Asia-Pacific region. Diabetes Care 2003, 26(2):360-366.
    • 16. Kannel WB: Lipids, diabetes, and coronary heart disease: insights from the Framingham Study. Am Heart J 1985, 110(5):1100-1107.
    • 17. Stamler J, Vaccaro O, Neaton JD, Wentworth D: Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993, 16(2):434-444.
    • 18. Barzilay JI, Spiekerman CF, Kuller LH, Burke GL, Bittner V, Gottdiener JS, Brancati FL, Orchard TJ, O'Leary DH, Savage PJ, Cardiovascular Health Study: Prevalence of clinical and isolated subclinical cardiovascular disease in older adults with glucose disorders: the Cardiovascular Health Study. Diabetes Care 2001, 24(7):1233-1239.
    • 19. Fisman EZ, Motro M, Tenenbaum A, Boyko V, Mandelzweig L, Behar S: Impaired fasting glucose concentrations in nondiabetic patients with ischemic heart disease: a marker for a worse prognosis. Am Heart J 2001, 141(3):485-490.
    • 20. Al-Nozha MM, Al-Maatouq MA, Al-Mazrou YY, Al-Harthi SS, Arafah MR, Khalil MZ, Al-Khadra A, Al-Marzouki K, Nouh MS, Abdullah M, Attas O, Al-Shahid MS, Al-Mobeireek A: Diabetes mellitus in Saudi Arabia. Saudi Med J 2004, 25(11):1603-1610.
    • 21. Lonnqvist F, Arner P, Nordfors L, Schalling M: Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1995, 1(9):950-953.
    • 22. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al.: Serum immunoreactive-leptin concentrations in normalweight and obese humans. N Engl J Med 1996, 334(5):292-295.
    • 23. Al-Daghri N, Al-Rubean K, Bartlett WA, Al-Attas O, Jones AF, Kumar S: Serum leptin is elevated in Saudi Arabian patients with metabolic syndrome and coronary artery disease. Diabet Med 2003, 20(10):832-837.
    • 24. American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care 2004, 27(Suppl 1):S5-S10.
    • 25. Matthews DR, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28(7):412-419.
    • 26. Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK: Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 1990, 263(21):2893-2898.
    • 27. Medalie JH, Papier CM, Goldbourt U, Herman JB: Major factors in the development of diabetes mellitus in 10,000 men. Arch Intern Med 1975, 135(6):811-817.
    • 28. McPhillips JB, Barrett-Connor E, Wingard DL: Cardiovascular disease risk factors prior to the diagnosis of impaired glucose tolerance and non-insulin-dependent diabetes mellitus in a community of older adults. Am J Epidemiol 1990, 131(3):443-453.
    • 29. Weyer C, Bogardus C, Mott DM, Pratley RE: The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999, 104(6):787-794.
    • 30. Pyorala M, Miettinen H, Laakso M, Pyorala K: Hyperinsulinemia and the risk of stroke in healthy middle-aged men: the 22- year follow-up results of the Helsinki Policemen Study. Stroke 1998, 29(9):1860-1866.
    • 31. Jarrett RJ: Why is insulin not a risk factor for coronary heart disease? Diabetologia 1994, 37(9):945-947.
    • 32. Niskanen L, Rauramaa R, Miettinen H, Haffner SM, Mercuri M, Uusitupa M: Carotid artery intima - media thickness in elderly patients with NIDDM and in nondiabetic subjects. Stroke 1996, 27(11):1986-1992.
    • 33. Welin L, Eriksson H, Larsson B, Ohlson LO, Svardsudd K, Tibblin G: Hyperinsulinaemia is not a major coronary risk factor in elderly men: The study of men born in 1913. Diabetologia 1992, 35(8):766-770.
    • 34. DeFronzo RA, Ferrannini E: Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes 1991, 14(3):173-194.
    • 35. Reaven GM, Laws A: Insulin resistance, compensatory hyperinsulinaemia, and coronary heart disease. Diabetologia 1994, 37(9):948-952.
    • 36. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S: Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 1987, 36(1):54-59.
    • 37. Castracane VD, Henson MC: When did leptin become a reproductive hormone? Semin Reprod Med 2002, 20(2):89-92.
    • 38. Alexander CM, Landsman PB, Teutsch SM: Diabetes mellitus, impaired fasting glucose, atherosclerotic risk factors, and prevalence of coronary heart disease. Am J Cardiol 2000, 86(9):897-902.
    • 39. Zhong N, Wu XP, Xu ZR, Wang AH, Luo XH, Cao XZ, Xie H, Shan PF, Liao EY: Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clin Chim Acta 2005, 351(1- 2):161-168.
    • 40. Maugeri D, Bonanno MR, Speciale S, Santangelo A, Lentini A, Russo MS, Calanna A, Malaguarnera M, Motta M, Testai' M, Panebianco P: The leptin, a new hormone of adipose tissue: clinical findings and perspectives in geriatrics. Arch Gerontol Geriatr 2002, 34(1):47-54.
    • 41. Leonhardt W, Horn R, Brabant G, Breidert M, Temelkova-Kurktschiev T, Fucker K, Hanefeld M: Relation of free and specifically bound leptin to insulin secretion in patients with impaired glucose tolerance (IGT). Exp Clin Endocrinol Diabetes 1997, 107(1):46-52.
    • 42. Asakawa H, Tokunaga K, Kawakami F: Relationship of leptin level with metabolic disorders and hypertension in Japanese type 2 diabetes mellitus patients. J Diabetes Complications 2001, 15(2):57-62.
    • 43. Couillard C, Mauriege P, Prud'homme D, Nadeau A, Tremblay A, Bouchard C, Despres JP: Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease. Diabetologia 1997, 40(10):1178-1184.
    • 44. Reilly MP, Iqbal N, Schutta M, Wolfe ML, Scally M, Localio AR, Rader DJ, Kimmel SE: Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab 2004, 89(8):3872-3878.
    • 45. Lichnovska R, Gwozdziewiczova A, Hrebicek J: Gender differences in factors influencing insulin resistance in elderly hyperlipemic non-diabetic subjects. Cardiovasc Diabetol 2002, 1:4.
    • 46. Adamia N, Virsaladze D, Charkviani N, Skhirtladze M, Khutsishvili M: Effect of metformin therapy on plasma adiponectin and leptin levels in obese and insulin resistant postmenopausal females with type 2 diabetes. Georgian Med News 2007:52-55.
    • 47. Liew CF, Seah ES, Yeo KP, Lee KO, Wise SD: Lean, nondiabetic Asian Indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to Caucasians and Chinese subjects. Int J Obes Relat Metab Disord 2003, 27(7):784-789.
    • 48. Lofgren I, Herron K, Zern T, West K, Patalay M, Shachter NS, Koo SI, Fernandez ML: Waist circumference is a better predictor than body mass index of coronary heart disease risk in overweight premenopausal women. J Nutr 2004, 134(5):1071-1076.
    • 49. Haffner SM, Gingerich RL, Miettinen H, Stern MP: Leptin concentrations in relation to overall adiposity and regional body fat distribution in Mexican Americans. Int J Obes Relat Metab Disord 1996, 20(10):904-908.
    • 50. Kafulafula G, Moodley J: Leptin levels in the obese African parturient. J Obstet Gynaecol 2001, 21(3):228-231.
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article