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Rupasinghe, Vasantha; Sekhhon-Loodu, Satvir; Mantso, Theodora; Panagiotidis, Mihalis (2016)
Publisher: Elsevier
Languages: English
Types: Article
Subjects: B100, C100, B900, C900, A100, B200, B400
Excessive accumulation of fat as the result of more energy intake and less energy expenditure is known as obesity. Lipids are essential components in the human body and are vital for maintaining homeostasis and physiological as well as cellular metabolism. Fatty acid synthesis and catabolism (by fatty acid oxidation) are normal part of basic fuel metabolism in animals. Fatty acids are degraded in the mitochondria by a biochemical process called β-oxidation in which two-carbon fragments are produced in each cycle. The increase in fatty acid β-oxidation is negatively correlated with body mass index. Although healthy life style, avoiding Western diet, dieting and strenuous exercise are the commonly used methods to lose weight, they are not considered a permanent solution in addition to risk attenuation of basal metabolic rate (BMR). Pharmacotherapy offers benefits of weight loss by altering the satiety and lowering absorption of fat from the food; however, its side effects may outweigh the benefits of weight loss. Alternatively, dietary phytochemicals and natural health products offer great potential as an efficient weight loss strategy by modulating lipid metabolism and/or increasing BMR and thermogenesis. Specifically, polyphenols such as citrus flavonoids, green tea epigallocatechin gallate, resveratrol, capsaicin and curcumin, have been reported to increase lipolysis and induce fatty acid β-oxidation through modulation of hormone sensitive lipase, acetyl-coA carboxylase, carnitine acyl transferase and peroxisome proliferator-activated receptor gamma coactivator-1. In this review article, we discuss selected phytochemicals in relation to their integrated functionalities and specific mechanisms for weight loss.
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    • 36) Farhat, G., Drummond, S., Fyfe, L,. Al-Dujaili. E.A.S. (2014). Dark Chocolate: An Obesity Paradox or a Culprit for Weight Gain? Phytother Res, 28, 791-797.
    • 37) Faulds, M.H., Dahlman, W.K. (2012). Metabolic diseases and cancer risk. Curr Opin Oncol, 24, 58-61.
    • 38) Field, D.T., Williams, C.M., Butler, L.T. (2011). Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions. Physiol Behav, 103, 255-260.
    • 39) Filozof, C.M., Murua, C., Sanchez, M.P., Brailovsky, C., Perman, M., Gonzalez, C.D., et al. (2000). Low plasma leptin concentration and low rates of fat oxidation in weight-stable post-obese subjects. Obesity Research, 8, 205-210.
    • 40) Friedman, MI. (2007). Obesity and the hepatic control of feeding behavior. Drug News Perspect 20, 573-578.
    • 41) Galleano, M., Oteiza, P., Fraga, C. (2009). Cocoa, chocolate and cardiovascular disease. J Cardiovasc Pharmacol, 54, 483-490.
    • 42) Goldwasser, J., Cohen, P.Y., Yang, E., Balaguer, P., Yarmush, M.L., Nahmias, Y. (2010). Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha. PLoS One, 5, e12399.
    • 43) Gong, D.W., Monemdjou, S., Gavrilova, O., Leon, L.R., Marcus-Samuels, B., et al. (2000). Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem, 275, 16251-16257.
    • 44) González-Castejón, M., & Rodriguez-Casado, A. (2011). Dietary phytochemicals and their potential effects on obesity: a review. Pharmacol Research, 64, 438-455.
    • 61) Hurley, R.L., Anderson, K.A., Franzone, J.M., Kemp, B.E., Means, A.R., Witters, L.A. (2005). The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem, 280, 29060-29066.
    • 62) Hwang, J.T., Park, I.J., Shin, J.I., Lee, Y.K., Lee, S.K., Baik, H.W., et al. (2005). Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMPactivated protein kinase. Biochem Biophys Res Commun, 338, 694-649.
    • 63) Ishihara, K., Oyaizu, S., Onuki, K., Lim, K., Fushiki, T. (2000). Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr, 130, 2990-2995.
    • 64) Jang, E.M., Choi, M.S., Jung, U.J., et al. (2008). Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fatfed hamsters. Metabolism, 57, 1576-1583.
    • 65) Jayaprakasam, B., Olson, L.K., Schutzki, R.E., Tai, M.H., Nair, M.G. (2006). Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem, 11, 243-248.
    • 66) Jeon, S.M., Lee, S.A., Choi, M.S. (2014). Antiobesity and vasoprotective effects of resveratrol in apoE-deficient mice. J Med Food, 17, 310-316.
    • 67) Jeukendrup, A.E., Randell, R. (2011). Fat burners: nutrition supplements that increase fat metabolism. Obesity Reviews, 12, 841-851.
    • 68) Jiang, A., Wang, X., Shan, X., Li, Y., Wang, P., Jiang, P., Feng, Q. (2015). Curcumin reactivates silenced tumor suppressor gene RARbeta by reducing DNA methylation. Phytother Res, 29, 1237-1245.
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