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Forrest, Michael D. (2013)
Publisher: Public Library of Science
Journal: PLoS ONE
Languages: English
Types: Article
Subjects: Computational Biology, Single Neuron Function, Research Article, Molecular Cell Biology, Neurochemistry, Computational Neuroscience, Neurons, QA, Biophysic Al Simulations, QH301, Physics, Biochemistry Simulations, Biophysics Simulations, Biophysics, Cellular Types, Biology, Neuroscience, Biochemical Simulations, Medicine, Cellular Neuroscience, Q, R, Science, Biochemistry, Cognitive Neuroscience
In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst. The mechanism of this bursting is incompletely understood. We have constructed a biophysical Purkinje soma model, guided and constrained by experimental reports in the literature, that can replicate the somatically driven bursting pattern and which hypothesises Persistent Na(+) current (INaP) to be its burst initiator and SK K(+) current (ISK) to be its burst terminator.

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