LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Forrest, Michael D. (2013)
Publisher: Public Library of Science
Journal: PLoS ONE
Languages: English
Types: Article
Subjects: Computational Biology, Single Neuron Function, Research Article, Molecular Cell Biology, Neurochemistry, Computational Neuroscience, Neurons, QA, Biophysic Al Simulations, QH301, Physics, Biochemistry Simulations, Biophysics Simulations, Biophysics, Cellular Types, Biology, Neuroscience, Biochemical Simulations, Medicine, Cellular Neuroscience, Q, R, Science, Biochemistry, Cognitive Neuroscience
In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst. The mechanism of this bursting is incompletely understood. We have constructed a biophysical Purkinje soma model, guided and constrained by experimental reports in the literature, that can replicate the somatically driven bursting pattern and which hypothesises Persistent Na(+) current (INaP) to be its burst initiator and SK K(+) current (ISK) to be its burst terminator.

Share - Bookmark

Cite this article