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Komura, S.; Shirotori, H.; Olmsted, P.D.; Andelman, D. (2004)
Publisher: EDP Sciences
Languages: English
Types: Article

Classified by OpenAIRE into

arxiv: Quantitative Biology::Cell Behavior, Physics::Biological Physics, Condensed Matter::Soft Condensed Matter, Quantitative Biology::Subcellular Processes, Quantitative Biology::Biomolecules
mesheuropmc: lipids (amino acids, peptides, and proteins)
In an effort to understand "rafts" in biological membranes, we propose phenomenological models for saturated and unsaturated lipid mixtures, and lipid-cholesterol mixtures. We consider simple couplings between the local composition and internal membrane structure, and their influence on transitions between liquid and gel membrane phases. Assuming that the gel transition temperature of the saturated lipid is shifted by the presence of the unsaturated lipid, and that cholesterol acts as an external field on the chain melting transition, a variety of phase diagrams are obtained. The phase diagrams for binary mixtures of saturated/unsaturated lipids and lipid/cholesterol are in semi-quantitative agreement with the experiments. Our results also apply to regions in the ternary phase diagram of lipid/lipid/cholesterol systems. \ud \ud
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