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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Lagator, Mato
Languages: English
Types: Doctoral thesis
Subjects: QK
Our\ud understanding\ud of\ud the\ud evolutionary\ud dynamics\ud of\ud selection\ud for\ud herbicide\ud resistance\ud is\ud limited\ud by\ud the\ud time\ud and\ud space\ud required\ud to\ud conduct\ud meaningful\ud selection\ud experiments\ud in\ud higher\ud plants.\ud This\ud constrains\ud the\ud study\ud of\ud the\ud dynamics\ud of\ud resistance\ud evolution\ud predominantly\ud to\ud mathematical\ud models.\ud The\ud primary\ud goal\ud of\ud this\ud thesis\ud was\ud to\ud overcome\ud these\ud limitations,\ud and\ud to\ud study\ud the\ud evolutionary\ud phenomena\ud underpinning\ud several\ud management\ud strategies.\ud To\ud do\ud so,\ud a\ud series\ud of\ud experimental\ud evolution\ud studies\ud were\ud conducted\ud using\ud Chlamydomonas\ud reinhardtii,\ud a\ud single-­‐cell\ud green\ud chlorophyte\ud susceptible\ud to\ud a\ud range\ud of\ud commercial\ud herbicides.\ud In\ud particular,\ud this\ud thesis\ud explored\ud the\ud impact\ud of\ud herbicide\ud sequences,\ud rotations\ud and\ud mixtures,\ud as\ud well\ud the\ud impact\ud of\ud herbicide\ud dose,\ud on\ud evolution\ud of\ud resistance.\ud Applying\ud herbicides\ud in\ud sequence\ud allowed\ud the\ud study\ud of\ud the\ud impact\ud of\ud environmental\ud perturbation\ud on\ud the\ud dynamics\ud of\ud resistance\ud and\ud the\ud associated\ud fitness\ud costs,\ud finding\ud more\ud rapid\ud selection\ud for\ud resistance\ud to\ud a\ud second\ud and\ud third\ud mode\ud of\ud action\ud in\ud some\ud populations.\ud Cycling\ud between\ud herbicides\ud creates\ud conditions\ud of\ud temporal\ud environmental\ud heterogeneity,\ud the\ud outcomes\ud of\ud which\ud are\ud not\ud easily\ud predictable\ud as\ud resistance\ud was\ud slowed\ud down\ud in\ud some\ud cycling\ud regimes,\ud while\ud in\ud others\ud it\ud accelerated\ud the\ud evolution\ud of\ud resistance\ud or\ud gave\ud rise\ud to\ud cross-­‐resistance.\ud Herbicide\ud mixtures\ud are\ud a\ud management\ud strategy\ud relying\ud on\ud increases\ud in\ud environmental\ud complexity\ud to\ud provide\ud better\ud control\ud of\ud resistance.\ud The\ud results\ud presented\ud show\ud that\ud mixtures\ud were\ud effective\ud at\ud slowing\ud the\ud evolution\ud of\ud resistance\ud when\ud all\ud mixture\ud components\ud were\ud used\ud at\ud fully\ud effective\ud doses,\ud while\ud low\ud doses\ud of\ud mixtures\ud accelerated\ud resistance\ud evolution\ud and\ud led\ud to\ud more\ud cross-­‐resistance.\ud Finally,\ud modifications\ud of\ud the\ud applied\ud herbicide\ud dose\ud allowed\ud the\ud study\ud of\ud local\ud adaptation\ud along\ud an\ud environmental\ud gradient,\ud where\ud the\ud differences\ud in\ud outcomes\ud based\ud on\ud the\ud specific\ud herbicides\ud used\ud were\ud again\ud evident.\ud Overall,\ud the\ud work\ud presented\ud here\ud uses\ud applied\ud scenarios\ud to\ud study\ud the\ud underlying\ud evolutionary\ud phenomena,\ud in\ud order\ud to\ud feed\ud back\ud into\ud the\ud applied\ud thinking.
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    • Bergstrom, C. T. & Feldgarden, M. 2007. The Ecology and Evolution of Antibiotic-Resistant Bacteria.
    • in: Evolution in Health and Disease, eds. S. Stearns, J. Koella, Oxford University Press, UK Bergstrom, C. T., Lo, M. & Lipsitch, M. 2004. Ecological Theory Suggests that Antimicrobial Cycling Will Not Redude Antimicrobial Resistance in Hospitals. Proceedings of Natural Academy of Sciences, 101, 13285-13290.
    • Birch, C. P. D. & Shaw, M. W. 1997. When can Reduced Doses and Pesticide Mixtures Delay the Buildup of Pesticide Resistance? A Mathematical Model. Journal of Applied Ecology, 34, 1032-1042.
    • Birky, C. W. 1995. Uniparental Inheritance of Mitochondrial and Chloroplast Genes: Mechanisms and Evolution. Proceedings of Natural Academy of Sciences, 92, 11331-11338.
    • Blackshaw, R. E., O'Donovan, J. T., Harker, N. K., Clayton, G. W. & Stougaard, R. N. 2006. Reduced Herbicide Doses in Field Crops: A Review. Weed Biology and Management, 6, 10-17.
    • Blumel, S. & Gross, M. 2001. Effect of Pesticide Mixtures on the Predatory Mite Phytoseiulus persimilis A.H. (Acarina, Phytoseiidae) in the Laboratory. Journal of Applied Entomology, 125, 201-205.
    • Bonhoeffer, S., Lipsitch, M. & Levin, B. 1997. Evaluating Treatment Protocols to Prevent Antibiotic Resistance. Proceedings of Natural Academy of Sciences, 94, 12106-12111.
    • Boote, K., Jones, J., Mishoe, J. & Berger, R. 1983. Coupling Pests to Crop Growth Simulators to Predict Yield Reductions. Phytopathology, 72, 1581-1587.
    • Booth, I. R. 2002. Stress and the single cell: Intrapopulation Diversity is a Mechanism to Ensure Survival Upon Exposure to Stress. International Journal of Food Microbiology, 78, 19-30.
    • Bradshaw, L. D., Padgette, S. R., Kimball, S. L. & Wells, B. H. 1997. Perspectives on Glyphosate Resistance. Weed Technology, 11, 189-198.
    • Brown, E. M. & Nathwani, D. 2005. Antibiotic Cycling or Rotation: a Systematic Review of the Evidence of Efficacy. Journal of Antimicrobial Chemotherapy, 55, 6-9.
    • Buckling, A., Brockhurst, M., Travisano, M. & Rainey, P. 2006. Experimental Adaptation to High and Low Quality Environments under Different Scales of Temporal Variation. Journal of Evolutionary Biology, 20, 296-300.
    • Buckling, A., MacLean, C., Brockhurst, M. A. & Colegrave, N. 2009. The Beagle in a Bottle. Nature, 475, 824-829.
    • Busi, R. & Powles, S. B. 2009. Evolution of Glyphosate Resistance in a Lolium rigidum Population by Glyphosate Selection at Sublethal Doses. Heredity, 103, 318-325.
    • Buttel, F. H. 2002. Economic and Social Aspects of Pest Management. in: Encyclopedia of Pest Management, Ed. D. Pimentel, CRC Press, USA p. 221-223.
    • Caprio, M. A. 1998. Evaluating Resistance Management Strategies for Multiple Toxins in the Presence of External Refugees. Journal of Economic Entomology, 91, 1021-1031.
    • Carroll, S., Kinnison, M. T. & Bernatchez, L. 2011. In Light of Evolution: Interdisciplinary Challenges in Food, Health, and the Environment. Evolutionary Applications, 4, 155-158.
    • Castle, S. J., Toscano, N. C., Prabhaker, N., Henneberry, T. J. & Palumbo, J. C. 2007. Field Evaluation of Different Insecticide Use Strategies as Resistance Management and Control Tactics for Bemisia tabaci (Hemiptera: Aleyrodidae). Bulletin of Entomological Research, 92, 449-460.
    • Charlesworth, B. 1992. Evolutionary Rates in Partially Self-Fertilizing Species. American Naturalist, 140, 126-148.
    • Charmantier, A. & Garant, D. 2005. Environmental Quality and Evolutionary Potential: Lessons from Wild Populations. Proceedings of the Royal Society B: Biological Sciences, 272, 1415-1425.
    • Chesson, P. 2000. Mechanisms of Maintenance of Species Diversity. Annual Review of Ecological Systems, 31, 343-366.
    • Chevillon, C., Pasteur, N., Marquine, M., Heyse, D. & Raymond, M. 1995. Population Structure and Dynamics of Selected Genes in the Mosquito Culex pipiens. Evolution, 49, 997-1007.
    • Chevin, L.-M., Lande, R. & Mace, G. M. 2010. Adaptation, Plasticity, and Extinction in a Changing Environment: Towards a Predictive Theory. PLoS biology, 8, e1000357.
    • Clark, A. 1984. Natural Selection with Nuclear and Cytoplasmic Transmission. I. A Deterministic Model.
    • Genetics, 107, 679-701.
    • Cohan, F., King, E. & Zawadzki, P. 1994. Amelioration of the Deleterious Pleiotropic Effects of an Adaptive Mutation in Bacillus subtilis. Evolution, 48, 81-95.
    • Colegrave, N. 2002. Sex Releases the Speed Limit on Evolution. Nature, 420, 664-666.
    • Collins, S. 2011. Many Possible Worlds: Expanding the Ecological Scenarios in Experimental Evolution.
    • Evolutionary Biology, 38, 3-14.
    • Collins, S., de Meaux, J. & Acquisti, C. 2007. Adaptive Walks Toward a Moving Optimum. Genetics, 176, 1089-1099.
    • Cooper, J. & Dobson, H. 2007. The Benefits of Pesticides to Mankind and the Environment. Crop Protection, 26, 1337-1348.
    • Coustau, C., Chevillon, C. & ffrench-Constant, R. 2000. Resistance to Xenobiotics and Parasites: Can we Count the Cost? Trends in Evolution and Ecology, 15, 378-383.
    • Crow, J. & Kimura, M. 1970. An Introduction to Population Genetics Theory. Harper & Row Publishing USA.
    • Davies, J. & Davies, D. 2010. Origins and Evolution of Antibiotic Resistance. Microbiology and Molecular Biology Reviews, 74, 417-433.
    • Delye, C., Gardin, J., Boucansaud, K., Chauvel, B. & Petit, C. 2011. Non-Target-Site-Based Resistance Should be the Centre of Attention for Herbicide Resistance Research: Alopecurus myosuroides as an illustration. Weed Research, 51, 433-437.
    • Denholm, I. & Rowland, M. 1992. Tactics for Managing Pesticide Resistance in Arthropods: Theory and Practice. Annual Review of Entomology, 37, 91-112.
    • Diggle, A., Neve, P. B. & Smith, F. P. 2003. Herbicides Used in Combination Can Reduce the Probability of Herbicide Resistance in Finite Weed Populations. Weed Research, 43, 371-382.
    • Doyle, P. & Stypa, M. 2004. Reduced Herbicide Rates - A Canadian Perspective. Weed Technology, 18, 1157-1165.
    • Drlica, K. 2003. The Mutant Selection Window and Antimicrobial Resistance. Journal of Antimicrobial Chemotherapy, 52, 11-17.
    • Duke, S. 1996. Herbicide-Resistant Crops: Agricultural, Environmental, Economic, Regulatory and Technical Aspects. CRC Press, Boca Raton, USA.
    • Eizaguirre, C. & Lenz, T. L. 2010. Major Histocompatibility Complex Polymorphism: Dynamics and Consequences of Parasite-Mediated Local Adaptation in Fishes. Journal of Fish Biology, 77, 2023-2047.
    • Elad, Y., Unis, H. & Katan, T. 1992. Multiple Fungicide Resistance to Benzimidazoles, Dicarboximides and Diethofencarb in Field Isolates of Botrytis cinerea in Israel. Plant Pathology, 41, 41-46.
    • Elena, S. F. & Lenski, R. E. 2003. Evolution Experiments with Microorganisms: the Dynamics and Genetic Bases of Adaptation. Nature Reviews Genetics, 4, 457-469.
    • Hartfield, M. & Keightley, P. D. 2012. Current Hypotheses for the Evolution of Sex and Recombination.
    • Integrative Zoology, 7, 192-209.
    • Heap, I. 2012. International Survey of Herbicide Resistant Weeds. www.weedscience.com, accessed on 5th October, 2012.
    • Hedrick, P. W. 1986. Genetic Polymorphism in Heterogeneous Environments: A Decade Later. Annual review of Ecology and Systematics, 17, 535-566.
    • Hegreness, M., Shoresh, N., Damian, D., Hartl, D. & Kishony, R. 2008. Accelerated Evolution of Resistance in Multidrug Environments. Proceedings of Natural Academy of Sciences, 105, 13977-13981.
    • Heller, R. & Smith, J. M. 1978. Does Muller's Ratchet Work with Selfing? Genetical Research, 32, 289- 293.
    • Hereford, J. 2009. A Quantitative Survey of Local Adaptation and Fitness Trade Offs. The American Naturalist, 173, 579-588.
    • Herms, D. & Mattson, W. 1994. Plant Growth and Defense. Trends in Ecology and Evolution, 9, 488.
    • Hill, C., Cotter, P., Sleator, R. & Gahan, C. 2002. Bacterial Stress Response in Listeria monocytogenes: Jumping the Hurdles Imposed by Minimal Processing. International Dairy Journal, 12, 273-283.
    • Hirschberg, J. & McIntosh, L. 1983. Molecular Basis of Herbicide Resistance in Amaranthus hybridus.
    • Science, 222, 1346-1349.
    • Hokkanen, H. 2002. Chapter 33: Biological Control: Successes and Failures. in: Encyclopedia of Pest Management, Ed. Pimentel D., CRC Press, USA. 102-104.
    • Holt, R. D. 1996. Evolution in Source-Sink Environments: Direct and Indirect Effects of DensityDependence on Niche Evolution. Oikos, 75, 182-192.
    • Immaraju, J. A., Morsei, J. G. & Hobzn, R. F. 1990. Field Evaluation of Insecticide Rotation and Mixtures as Strategies for Citrus Thrips (Thysanoptera: Thripidae) Resistance Management in California.
    • Journal of Economic Entomology, 83, 306-314.
    • Isturiz, R. E. 2010. Optimizing Antimicrobial Prescribing. International Journal of Antimicrobial Agents, 36, S19-S22.
    • Jander, G., Baerson, S. R., Hudak, J. A., Gonzalez, K. A., Gruys, K. J. & Last, R. L. 2003.
    • Ethylmethanesulfonate Saturation Mutagenesis in Arabidopsis to Determine Frequency of Herbicide Resistance. Plant Pathology, 131, 139-146.
    • Jasieniuk, M., Brule-Babel, A. L. & Morrison, I. N. 1996. The Evolution and Genetics of Herbicide Resistance in Weeds. Weed Science, 44, 176-193.
    • Jasmin, J.-N. & Kassen, R. 2007. On the Experimental Evolution of Specialization and Diversity in Heterogeneous Environments. Ecology Letters, 10, 272-281.
    • 2010. Rotation of Treatments between Spinosad and Amitraz for the Control of Rhipicephalus (Boophilus) microplus Populations with Amitraz Resistance. Veterinary Parasitology, 169, 157-164.
    • Kassen, R. 2002. The Experimental Evolution of Specialists, Generalists, and the Maintenance of Diversity.
    • Journal of evolutionary biology, 15, 173-190.
    • Kassen, R. & Bell, G. 1998. Experimental Evolution in Chlamydomonas. IV Selection in Environments that Vary Through Time at Different Scales. Heredity, 80, 732-741.
    • Kassen, R. & Bell, G. 2000. The Ecology and Genetics of Fitness in Chlamydomonas. X. The Relationship between Genetic Correlation and Genetic Distance. Evolution, 54, 425-432.
    • Kawecki, T. J. & Ebert, D. 2004. Conceptual Issues in Local Adaptation. Ecology Letters, 7, 1225-1241.
    • Kawecki, T. J., Lenski, R. E., Ebert, D., Hollis, B., Olivieri, I. & Whitlock, M. C. 2012. Experimental evolution. Trends in Ecology and Evolution, 27, 547-560.
    • Kishony, R. & Leibler, S. 2003. Environmental Stresses can Alleviate the Average Deleterious Effect of Mutations. Journal of Biology, 2, 14.
    • Kover, P. X., Rowntree, J. K., Scarcelli, N., Savriama, Y., Eldridge, T. & Schaal, B. A. 2009.
    • Pleiotropic Effects of Rnvironment-Specific Adaptation in Arabidopsis thaliana. New Phytologist, 183, 816-825.
    • Lagator, M., Vogwill, T., Colegrave, N. & Neve, P. 2012. Herbicide Cycling has Diverse Effects on Evolution of Resistance in Chlamydomonas reinhardtii. Evolutionary Applications, ISSN 1752-4571.
    • Lande, R. & Arnold, S. J. 1983. Continuous, Alternating, and Mixed Insecticides Affect Development of Resistance in the horn Fly (Diptera: Muscidae). Evolution, 37, 1210-1226.
    • Roff, D. A. & Fairbairn, D. J. 2006. The Evolution of Trade-Offs: Where are We? Journal of Evolutionary Biology, 20, 433-447.
    • Roush, R. T. & McKenzie, J. A. 1987. Ecological Genetics of Insecticide and Acaricide Resistance.
    • Annual Review of Entomology, 32, 361-380.
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