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Tylee, André; Ashworth, Mark; Barley, Elizabeth; Brown, June; Chambers, John; Farmer, Anne; Fortune, Zoe; Haddad, Mark; Lawton, Rebecca; Mann, Anthony; Mehay, Anita; McCrone, Paul; Murray, Joanna; Leese, Morven; Pariante, Carmine M; Rose, Diana; Rowlands, Gill; Smith, Alison; Walters, Paul (2011)
Publisher: BioMed Central
Journal: BMC Family Practice
Languages: English
Types: Article
Subjects: Family Practice, R5-920, Medicine (General), Study Protocol, RA



Coronary heart disease and depression are both common health problems and by 2020 will be the two leading causes of disability worldwide. Depression has been found to be more common in patients with coronary heart disease but the nature of this relationship is uncertain. In the United Kingdom general practitioners are now being remunerated for case-finding for depression in patients with coronary heart disease, however it is unclear how general practitioners should manage these patients. We aim to explore the relationship between coronary heart disease and depression in a primary care population and to develop an intervention for patients with coronary heart disease and depression.


This programme of research will consist of 4 inter-related studies. A 4 year prospective cohort study of primary care patients with coronary heart disease will be conducted to explore the relationship between coronary heart disease and depression. Within this, a nested case-control biological study will investigate genetic and blood-biomarkers as predictors of depression in this sample. Two qualitative studies, one of patients' perspectives of treatments for coronary heart disease and co-morbid depression and one of primary care professionals' views on the management of patients with coronary heart disease and depression will inform the development of an intervention for this patient group. A feasibility study for a randomised controlled trial will then be conducted.


This study will provide information on the relationship between coronary heart disease and depression that will allow health services to determine the efficiency of case-finding for depression in this patient group. The results of the cohort study will also provide information on risk factors for depression. The study will provide evidence on the efficacy and feasibility of a joint patient and professional led intervention and data necessary to plan a definitive randomised controlled trial of the intervention.

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    • 1. Murray CJ, Lopez AD: Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997, 349(9064):1498-504.
    • 2. Layard R: The case for psychological treatment centres. BMJ 2006, 332(7548):1030-2.
    • 3. Ustun TBSN, eds: Mental illness in general health care. An international study. Chichester, John Willey; 1995.
    • 4. National Collaborating Centre for Mental Health: Depression: Management of depression in primary and secondary care. London, National Institute for Clinical Excellence; 2008.
    • 5. Davidson KW, Kupfer DJ, Bigger JT, Califf RM, Carney RM, Coyne JC, et al: Assessment and treatment of depression in patients with cardiovascular disease: National Heart, Lung, and Blood Institute Working Group Report. Psychosomatic Medicine 2006, 68(5):645-50.
    • 6. O'Brien SM, Scott LV, Dinan TG: Antidepressant therapy and C-reactive protein levels. Br J Psychiatry 2006, 188:449-452.
    • 7. Katon W, Von Korff M, Lin E, Simon G, Ludman E, Bush T, et al: Improving primary care treatment of depression among patients with diabetes mellitus: the design of the pathways study. General Hospital Psychiatry 2003, 25(3):158-68.
    • 8. Dickens C, McGowan L, Percival C, Tomenson B, Cotter L, Heagerty A, et al: New onset depression following myocardial infarction predicts cardiac mortality. Psychosomatic Medicine 2008, 70(4):450-5.
    • 9. Health and Social Care Information Centre: National Quality and Outcomes framework statistics for England 2004/5. Statistical Bulletin 2005/04/HSCIC Health and Social Care Information Centre; 2005, 8-1- 2007.
    • 10. Glassman AH, O'Connor CM, Califf RM, Swedberg K, Schwartz P, Bigger JT Jr, et al: Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA 2002, 288(6):701-9.
    • 11. Berkman LF, Blumenthal J, Burg M, Carney RM, Catellier D, Cowan MJ, et al: Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial. JAMA 2003, 289(23):3106-16.
    • 12. Carney RM, Blumenthal JA, Freedland KE, Youngblood M, Veith RC, Burg MM, et al: Depression and late mortality after myocardial infarction in the Enhancing Recovery in Coronary Heart Disease (ENRICHD) study. Psychosomatic Medicine 2004, 66(4):466-74.
    • 13. Taylor CB, Youngblood ME, Catellier D, Veith RC, Carney RM, Burg MM, et al: Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Archives of General Psychiatry 2005, 62(7):792-8.
    • 14. Gensichen J, Beyer M, Muth C, Gerlach FM, Von Korff M, Ormel J: Case management to improve major depression in primary health care: a systematic review. Psychological Medicine 2006, 36(1):7-14.
    • 15. Von Korff M, Goldberg D: Improving outcomes in depression: The whole process of care needs to be enhanced. BMJ 2001, 323:948-949.
    • 16. Hamilton M: Development of a rating scale for primary depressive illness. British Journal of Social & Clinical Psychology 1967, 6:278-296.
    • 17. Rose GA: The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bulletin of the World Health Organization 1962, 27:645-58.
    • 18. Ware J Jr, Kosinski M, Keller SD: A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Medical Care 1996, 34(3):220-33.
    • 19. Cooke R, Smeeten N, Chambers J: Comparative study of chest pain characteristics in patients with normal and abnormal coronary angiograms. Heart 1997, 78:142-6.
    • 20. Goldman L, Hashimoto B, Cook EF, Loscalzo A: Comparative reproducibility and validity of systems for assessing cardiovascular functional class: advantages of a new specific activity scale. Circulation 1981, 64(6):1227-34.
    • 21. Goldberg D, Williams P: A user's guide to the General Health Questionnaire. Windsor: NFER-Nelson; 1988.
    • 22. Zigmond AS, Snaith RP: The hospital anxiety and depression rating scale. Acta Psychiatrica Scandinavica 1983, 67:361-370.
    • 23. Lewis G: Assessing psychiatric disorder with a human interviewer or a computer. Journal of Epidemiology & Community Health 1994, 48:207-210.
    • 24. Kroenke K, Spitzer RL, Williams JB: The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 2001, 16:606-613.
    • 25. Rabin R, de Charro F: EQ-5D: a measure of health status from the EuroQol Group. Annals of Medicine 2001, 33(5):337-43.
    • 26. Brugha TS, Cragg D: The List of Threatening Experiences: the reliability and validity of a brief life events questionnaire. Acta Psychiatr Scand 1990, 82:77-81.
    • 27. Corney RH, Clare AW: The construction, development and testing of a self-report questionnaire to identify social problems. Psychol Med 1985, 15:637-649.
    • 28. Beecham , Knapp M: Costing psychiatric interventions. In Measuring Mental Health Needs. Edited by: Thornicroft G. London: Gaskell; 2001:220-224.
    • 29. Broadbent E, Petrie KJ, Main J, Weinman J: The brief illness perception questionnaire. Journal of Psychosomatic Research 2006, 60(6):631-7.
    • 30. Ashworth M, Robinson S, Godfrey E, Shepherd M, Evans C, Seed P, et al: Measuring mental health outcomes in primary care: the psychometric properties of a new patient-generated outcome measure. Primary Care Mental Health 2005, 3:261-270.
    • 31. Davis TC, Long SW, Jackson RH, Mayeaux EJ, George RB, Murphy PW, et al: Rapid estimate of adult literacy in medicine: a shortened screening instrument. Family Medicine 1993, 25(6):391-5.
    • 32. Glaser BG, Strauss AL: The discovery of grounded theory: strategies for qualitative research Chicago: Aldine; 1967.
    • 33. Kroenke K, Spitzer RL, Williams JB: The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care 2003, 41:1284-1292.
    • 34. Wu EB, Smeeton N, Chambers JB: A chest pain score for stratifying the risk of coronary artery disease in patients having day case coronary angiography. International Journal of Cardiology 2001, 78(3):257-64.
    • 35. Morisky DE, Green LW, Levine DM: Concurrent and predictive validity of a self-reported measure of medication adherence. Medical Care 1986, 24:67-74.
    • 36. Tennant R, Hiller L, Fishwick R, Platt S, Joseph S, Weich S, et al: The Warwick-Edinburgh Mental Well-being Scale (WEMWBS): development and UK validation. Health & Quality of Life Outcomes 2007, 5:63.
    • 37. Ashworth M, Shepherd M, Christey J, Matthews V, Wright K, Parmentier H, et al: A client-centred psychometric instrument: the development of 'PSYCHLOPS' ('Psychological Outcomes Profiles'). Counselling and Psychotherapy Research 2004, 4:27-33.
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