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Caroline Peyrode; François Gouin; Aurélien Vidal; Philippe Auzeloux; Sophie Besse; Marie-Mélanie Dauplat; Serge Askienazy; Dominique Heymann; Jean-Michel Chezal; Françoise Redini; Elisabeth Miot-Noirault (2011)
Publisher: Hindawi Limited
Journal: Sarcoma
Languages: English
Types: Article
Subjects: Research Article, RC254-282, Article Subject, Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Classified by OpenAIRE into

mesheuropmc: viruses
Our lab developed 99mTc-NTP 15-5 radiotracer as targeting proteoglycans (PGs) for the scintigraphic imaging of joint. This paper reports preclinical results of 99mTc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (SRC). 99mTc-NTP 15-5 imaging of SRC-bearing and sham-operated animals was performed and quantified at regular intervals after surgery and compared to bone scintigraphy and tumoural volume. Tumours were characterized by histology and PG assay. SRC exhibited a significant 99mTc-NTP 15-5 uptake at very early stage after implant (with tumour/muscle ratio of 1.61 ± 0.14), whereas no measurable tumour was evidenced. As tumour grew, mean tumour/muscle ratio was increased by 2.4, between the early and late stage of pathology. Bone scintigraphy failed to image chondrosarcoma, even at the later stage of study. 99mTc-NTP 15-5 imaging provided a suitable set of quantitative criteria for the in vivo characterization of chondrosarcoma behaviour in bone environment, useful for achieving a greater understanding of the pathology.

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