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Okor, Roland; Fajuyigbe, Olanike; Eichie, Florence (2004)
Publisher: Austrian Pharmaceutical Society
Journal: Scientia Pharmaceutica
Languages: English
Types: Article
Subjects: antacid powders, adsorption, Ampicillin, bioavailability, adsorption mechanisms

Classified by OpenAIRE into

mesheuropmc: inorganic chemicals, digestive system diseases
these are bismuth carbonate, magnesium trisilicate and aluminium hydroxide. The adsorption of ampicillin by bismuth carbonate followed the Langmuir adsorption isotherm, which suggests chemisorptions. It was characterized by a strong adsorption at a low adsorbate (ampicillin) concentration but the % adsorption decreased with increase in adsorbate concentration, which is a feature of a saturated monolayer adsorption. On the other hand, the adsorption by magnesium trisilicate and aluminium hydroxide followed the Freundlich adsorption isotherm characterized by a low adsorption at a low adsobate concentration but this increased slightly with increase in adsorbate concentration, suggesting a weak physical adsorption. The adsorption capacities (mg/g) of the adsorbate were 1.64 (bismuth carbonate) 0.04 (magnesium carbonate) and 0.03 (aluminium hydroxide). Bismuth carbonate thus gave by far the highest degree of adsorption. The conclusion is that the co-administration of ampicillin and bismuth carbonate in the treatment of certain peptic ulcers is erroneous.
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    • [2] Sorby, D.L.
    • J. Pharm. Sci. 1965; 54: 677 - 680 Wagner, J.G.
    • Can. J. Pharm. Sci. 1966; 1: 55 - 68.
    • J. Antimicrob. Chemother. 1991; 28: 87 - 94.
    • Monograph on ampicillin In: British Pharmacopoeia 1988. Her Royal Majesty Stationary Office, London.
    • In: Tutorial Pharmacy. S.J.Carter (ed.) 6th ed. Pitman Medical, 1972: 42-50.
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