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Wang, Mei; Lu, Chun; Xu, Qing; Song, Si; Hu, Zhi; Zheng, Zhong (2013)
Publisher: Multidisciplinary Digital Publishing Institute
Journal: Molecules
Languages: English
Types: Article
Subjects: new metabolites, citrinin, Penicillium sp. ML226, Organic chemistry, QD241-441, marine fungus, Penicillium sp. ML226

Classified by OpenAIRE into

mesheuropmc: animal structures
Four new citrinin derivatives, including two citrinin dimers and two citrinin monomer derivatives, were isolated and identified from a marine-derived fungal strain Penicillium sp. ML226 along with six known related compounds. Their structures were elucidated by spectroscopic and chemical methods. The new compounds showed modest cytotoxic activity against HepG-2 cell line and weak antimicrobial activity against Staphylococcus aureus.
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    • Tamburini, E.; Mastromei, G. Do bacterial cryptic genes really exist? Res. Microbiol. 2000, 151, 179-182.
    • Liberra, K.; Lindequist, U. Marine fungi-A prolific resource of biologically active natural products? Pharmazie 1995, 50, 583-588.
    • Bugni, T.S.; Ireland, C.M. Marine-derived fungi: a chemically and biologically diverse group of microorganisms. Nat. Prod. Rep. 2004, 21, 143-163.
    • Wakana, D.; Hosoe, T.; Itabashi, T.; Okada, K.; Takaki, G.M.D.; Yaguchi, T.; Fukushima, K.; Kawai, K. New citrinin derivatives isolated from Penicillium citrinum. J. Nat. Med. 2006, 60, 279-284.
    • Biochem. 2007, 71, 499-503.
    • Hetherington, A.C.; Raistrick, H. Studies in the biochemistry of microorganisms. XI. On the production and chemical constitution of a new yellow coloring matter, citrinin, produced from glucose by Penicillium citrinum THOM. Philos. Trans. R. Soc. London Ser. B 1931, 220, 226-297.
    • Chen, C.H.; Shaw, C.Y.; Chen, C.C.; Tsai, Y.C. 2,3,4-Trimethyl-5,7-dihydroxy-2,3- dihydrobenzofuran, a novel antioxidant, from Penicillium citrinum F5. J. Nat. Prod. 2002, 65, 740-741.
    • 8. Rodel, T.; Gerlach, H. Enantioselective Synthesis of the Polyketide Antibiotic (3R,4S)-(-)- Citrinin. Liebigs Ann. 1995, 1995, 885-888.
    • 9. Lu, Z.Y.; Lin, Z.J.; Wang, W.L.; Du, L.; Zhu, T.J.; Fang, Y.C.; Gu, Q.Q.; Zhu, W.M. Citrinin dimers from the halotolerant fungus Penicillium citrinum B-57. J. Nat. Prod. 2008, 71, 543-546.
    • 10. Clark, B.R.; Capon, R.J.; Lacey, E.; Tennant, S.; Gill, J.H. Citrinin revisited: from monomers to dimers and beyond. Org. Biomol. Chem. 2006, 4, 1520-1528.
    • 11. Chien, M.M.; Schiff, P.L., Jr.; Slatkin, D.J.; Knapp, J.E. Metabolites of aspergilli. III. The isolation of citrinin, dihydrocitrinone and sclerin from aspergilus carneus. Lloydia 1977, 40, 301-302.
    • 12. Chen, L.; Liu, W.; Hu, X.; Huang, K.; Wu, J.L.; Zhang, Q.Q. Citrinin derivatives from the marine-derived fungus Penicillium citrinum. Chem. Pharm. Bull. (Tokyo) 2011, 59, 515-517.
    • 13. Xin, Z.H.; Wang, W.L.; Zhang, Y.P.; Xie, H.; Gu, Q.Q.; Zhu, W.M. Pennicitrinone D, a new citrinin dimer from the halotolerant fungus Penicillium notatum B-52. J. Antibiot. (Tokyo) 2009, 62, 225-227.
    • 14. Chen, L.; Liu, W.; Huang, K.; Hu, X.; Fang, Z.X.; Wu, J.L.; Zhang, Q.Q. Penicitrinols F-I, New Citrinin Derivatives from the Marine-Derived Fungus Penicillium citrinum. Heterocycles 2011, 83, 1853-1858.
    • 15. E, Z. Tissue Culture And Molecular Biology Technology; Beijing Publishing House: Beijing, China 1995; pp. 1-141.
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