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Publisher: Institute for Medical Research and Occupational Health
Journal: Arhiv za higijenu rada i toksikologiju
Languages: Serbian
Types: Article
Subjects:
The distribution, storage and toxic effects of PCB (Aroclor 1242) were examined. The results show that the greatest quantity of Aroclor 1242 administered as a single oral dose is stored in the fat tissues of rats. No statistically significant difference .in body weight gain was observed an animals given Aroclor 1242 for a period of 30 days when compared with control animals, but an increase in liver weight was established in test animals of both sexes. Serum alkaline phosphatase activity did not significantly change in animals administered Aroclor 1242, but statistically significant changes in serum glutamic-oxaloacetic (iSGOT) and serum glutamic-pyruvic transaminases (SGPT) activities were established. SGPT activity decreased in the test animals of both sexes, whereas SGOT activity increased in males, and decreased on females compared to control animals. At the same time, NADPH-cytochrome c reductase activity and cytochrome P-450 content increased significantly in test animals of both sexes. Finally, a statistically significant decrease on the acute toxicity of phorate and propoxur was established in animals given Aroclor 1242 for a period of 30 days.
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