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Hedison, Tobias; Hay, Sam; Scrutton, Nigel (2017)
Publisher: Elsevier BV
Journal: Nitric Oxide
Languages: English
Types: Article
Subjects: NOS, nitric oxide synthase, Protein dynamics, Physiology, FMN, flavin mononucleotide, MSR, methionine synthase reductase, Cytochrome P450 reductase, Article, Cancer Research, CPR, cytochrome P450 reductase, FRET, F?rster resonance energy transfer, P450 BM3, cytochrome P450 BM3, Fluorescence, FAD, flavin adenosine dinucleotide, Biochemistry, Clinical Biochemistry, Nitric oxide synthase, Diflavin oxidoreductase, CaM, calmodulin
This perspective reviews single molecule and ensemble fluorescence spectroscopy studies of the three tissue specific nitric oxide synthase (NOS) isoenzymes and the related diflavin oxidoreductase cytochrome P450 reductase. The focus is on the role of protein dynamics and the protein conformational landscape and we discuss how recent fluorescence-based studies have helped in illustrating how the nature of the NOS conformational landscape relates to enzyme turnover and catalysis.

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